A5009302310- Pancreatic and Hepatic Oncology Research
- Thyroid and Parathyroid Surgery
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Hernia repair and management
- Parathyroid Disorders and Treatments
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
- Pelvic and Acetabular Injuries
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Appendicitis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Biliary and Gastrointestinal Fistulas
- Adrenal and Paraganglionic Tumors
- Voice and Speech Disorders
- Airway Management and Intubation Techniques
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Intraperitoneal and Appendiceal Malignancies
- Pituitary Gland Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
Centre Hospitalier Universitaire de Limoges
2016-2025
Université de Limoges
2016-2025
Hôpital Dupuytren
2015-2025
Inserm
2014-2025
Université de Caen Normandie
2024
Hôpital Universitaire Dupuytren
2016-2023
CNR de la Résistance aux Antibiotiques
2019-2023
Centre National de la Recherche Scientifique
2001-2022
Digestive Health Research Institute
2020-2021
Centre Hospitalier Universitaire de Lille
2020
Abstract Background Radical surgery provides the best chance of cure for adrenocortical carcinoma (ACC), but perioperative surgical care these patients is yet to be standardized. Methods A working group appointed jointly by ENSAT and ESES used Delphi methodology produce evidence-based recommendations with ACC. Papers were retrieved from electronic databases. Evidence classified according Grading Recommendations, Assessment, Development Evaluation (GRADE) system, discussed until consensus was...
Research Article1 April 2015Open Access Source Data Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance Camille Duluc INSERM UMR-1037, Cancer Center Toulouse (CRCT), Equipe labellisée Ligue Contre le and Laboratoire d'Excellence (TOUCAN), Université de Toulouse, France Search for more papers by this author Siham Moatassim-Billah Biochemistry-Immunology Laboratory, Faculty Sciences Rabat,...
Abstract Purpose: Circulating cell-free DNA (ccfDNA) is a valuable source of tumor material obtained from simple blood sampling that enables noninvasive analysis the genome. Our goal was to carry out multiparametric ccfDNA and evaluate its prognostic value by investigating overall survival (OS) 97 metastatic colorectal cancer patients (mCRC). Experimental Design: Qualitative parameters (determination main KRAS exon2 BRAF V600E mutations) quantitative (total concentration, mutant proportion...
We used a novel method based on allele-specific quantitative polymerase chain reaction (Intplex) for the analysis of circulating cell.free DNA (ccfDNA) to compare total ccfDNA and KRAS- or BRAF-mutated concentrations in blood samples from mice xenografted with human SW620 colorectal cancer (CRC) cell line patients CRC. Intplex enables single-copy detection variant alleles down sensitivity ≥0.005 mutant wild-type ratio. The proportion allele corresponding percentage tumor-derived was elevated...
Ninety percent of cases acute calculous cholecystitis are mild (grade I) or moderate II) severity. Although the preoperative and intraoperative antibiotic management has been standardized, few data exist on utility postoperative treatment.To determine effect amoxicillin plus clavulanic acid infection rates after cholecystectomy.A total 414 patients treated at 17 medical centers for grade I II who received 2 g 3 times a day while in hospital before once time surgery were randomized to an...
Article7 October 2020Open Access Source DataTransparent process FAK activity in cancer-associated fibroblasts is a prognostic marker and druggable key metastatic player pancreatic cancer Sonia Zaghdoudi Cancer Research Center of Toulouse (CRCT), team 6 "Protein synthesis & secretion carcinogenesis", Equipe labellisée Ligue Contre Le Cancer, Labex TOUCAN, INSERM UMR 1037- University III Paul Sabatier, Toulouse, France Search for more papers by this author Emilie Decaup Ismahane Belhabib Rémi...
In Brief Objectives: To assess the impact of neoadjuvant chemoradiotherapy (NCRT) on anastomotic leakage (AL) and other postoperative outcomes after esophageal cancer (EC) resection. Background: Conflicting data have emerged from randomized studies regarding NCRT AL. Methods: Among 2944 consecutive patients operated for EC between 2000 2010 in 30 European centers, treated by surgery (n = 593) were compared with those primary 1487). Multivariable analyses propensity score matching used to...
Background Neurotrophin receptors were initially identified in neural cells. They recently detected some cancers association with invasiveness, but the function of these tyrosine kinase was not previously investigated colorectal cancer (CRC) Methods and Findings We report herein that human CRC cell lines synthesize growth factor Brain-derived neurotrophic (BDNF) under stress conditions (serum starvation). In parallel, cells expressed high- (TrkB) low-affinity (p75NTR) at plasma membrane,...
Colorectal cancer (CRC) is a common and lethal disease. It the third most type of in world, behind lung breast cancer, with almost 1.4 million new cases diagnosed 2012. The risk developing CRC influenced by environmental genetic factors. Adenocarcinomas comprise vast majority (98%) CRCs. A patient's likelihood survival associated tumor stage at time diagnosis. With regular screening, can be identified early, when treatment effective. However, typically asymptomatic until advanced stages....
Abstract Background Open studies have reported favourable results for sacral nerve stimulation in the treatment of refractory constipation. Here, its efficacy was assessed a double-blind crossover RCT. Methods Patients with at least two following criteria were included: fewer than three bowel movements per week; straining to evacuate on more 25 cent attempts; or sensation incomplete evacuation occasions. Response therapy defined as week and/or 50 improvement symptoms. Responders an initial...
Abstract Background Normocalcaemic primary hyperparathyroidism (NcPHPT) is a new clinical entity being diagnosed increasingly among patients with mild (PHPT). The aim of this study was to evaluate quality life and non-specific symptoms before after parathyroidectomy in NcPHPT compared those hypercalcaemic PHPT (Hc-m-PHPT). Methods This prospective multicentre from four university hospitals. Patients were evaluated operation, 3, 6 12 months surgery for using the SF-36-v2® questionnaire, as...
Cancer-associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Previously we described four CAF subtypes with specific molecular and functional features. Here, have refined our subtype signatures using RNAseq immunostaining goal defining bioinformatically phenotypic stromal tumor epithelial states associated diversity. We used primary cultures grown from patient PDAC tumors, human data sets (in-house public, including single-cell...
Importance The ability to attract and retain university hospital faculty staff is in jeopardy because of the high levels mental symptoms this professional group. Objective To examine prevalence determinants severe burnout, job strain, suicidal ideation tenured associate full professors hospitals. Design, Setting, Participants This nationwide cross-sectional study offered online surveys 5332 members France from October 25, 2021, December 20, 2021. Exposures Burnout strain. Main Outcomes...