A5007825619- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Inflammatory Bowel Disease
- Colorectal Cancer Treatments and Studies
- Pelvic floor disorders treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Appendicitis Diagnosis and Management
- Gastrointestinal Tumor Research and Treatment
- Stoma care and complications
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Microscopic Colitis
- Abdominal Surgery and Complications
- Autoimmune and Inflammatory Disorders
- Hernia repair and management
- Esophageal Cancer Research and Treatment
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
- Intestinal and Peritoneal Adhesions
Centre de Recherche Saint-Antoine
2012-2025
Hôpital Saint-Antoine
2016-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Sorbonne Nouvelle
2019-2024
Sorbonne Paris Cité
2019-2024
Inserm
2007-2024
La Ligue Contre le Cancer
2016-2023
Bristol-Myers Squibb (Germany)
2023
Mylan (Italy)
2023
Purpose To compare the long-term survival of patients with isolated and resectable peritoneal carcinomatosis (PC) in comparable groups treated systemic chemotherapy containing oxaliplatin or irinotecan by cytoreductive surgery plus hyperthermic intraperitoneal (HIPEC). Patients Methods All gross PC from colorectal adenocarcinoma who had undergone HIPEC 1998 to 2003 were evaluated. The standard group was constituted selecting palliative during same period, but not benefited because technique...
Purpose A pathologic complete response (pCR; ypT0N0) of a rectal tumor after neoadjuvant radiochemotherapy (RCT) is associated with an excellent prognosis. Several retrospective studies have investigated the effect increasing delay RCT. The aim this study was to evaluate interval between end RCT and surgery on pCR rate. Methods GRECCAR6 phase III, multicenter, randomized, open-label, parallel-group controlled trial. Patients cT3/T4 or Tx N+ tumors mid lower rectum who had received (45 50 Gy...
Gastric cancer (GC) with peritoneal metastases (PMs) is a poor prognostic evolution. Cytoreductive surgery (CRS) yields promising results, but the impact of hyperthermic intraperitoneal chemotherapy (HIPEC) remains controversial. Here we aimed to compare outcomes between CRS-HIPEC versus CRS alone (CRSa) among patients PMs from GC. From prospective databases, identified 277 GC who were treated complete curative intent (no residual nodules > 2.5 mm) at 19 French centers 1989 2014. Of these...
In patients with resectable gastric/gastroesophageal junction (GEJ) adenocarcinoma, surgery plus perioperative platinum-based chemotherapy is the standard of care. Perioperative remains debatable for gastric/GEJ adenocarcinoma deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H).NEONIPIGA (ClinicalTrials.gov identifier: NCT04006262) phase II study evaluated neoadjuvant nivolumab 240 mg once every two weeks ×6 and ipilimumab 1 mg/kg six ×2, followed by adjuvant 480 four...
In Brief Objective: To assess the infertility rate after laparoscopic ileal pouch-anal anastomosis (IPAA). Background: Total proctocolectomy with IPAA is known to be associated postoperative in open surgery, which may caused by pelvic adhesions affecting fallopian tubes. However, fertility has never been assessed. Methods: All patients who underwent a total between 2000 and 2011 were aged 45 years or less at time of operation 18 more data collection included. The answered questionnaire...
The aim of this large multicenter study was to assess the impact salvage esophagectomy after definitive chemoradiotherapy (SALV) on clinical outcome.Data from consecutive adult patients undergoing resection for esophageal cancer in 30 European centers 2000 2010 were collected. First, groups SALV (n = 308) and neoadjuvant followed by planned (NCRS; n 540) compared. Second, who benefited persistent 234) versus recurrent disease 74) Propensity score matching multivariable analyses used...
OBJECTIVES Many factors influence the career specialty decisions made by medical students. The aim of this study was to broaden consideration determinants choice in a large population students their sixth year study. METHODS A total 2588 distributed across all 39 schools France participated National Practice Examination December 2008, after which an electronic questionnaire administered. Study criteria were: characteristics; demographics, and motivation for drawbacks choice. RESULTS 1780...
The aim of this retrospective study was to evaluate the survival impact perioperative chemotherapy (PCT) in patients with gastric signet ring cell (SRC) adenocarcinoma.PCT is a standard treatment for advanced resectable adenocarcinoma (GA). SRC has worse prognosis compared non-SRC and chemosensitivity uncertain.Among 3010 registered 19 French centers between January 1997 2010, 1050 (34.9%) were diagnosed SRC. Of those treated curative intent (n = 924), 171 (18.5%) received PCT surgery (PCT...
To prospectively compare the results of pathologic examination including thin 3- to 4-mm thick serial slices surgical specimen in a well-defined anatomic part liver with those 4 different imaging techniques. BACKGROUNDS SUMMARY DATA: Liver metastases (LM) neuroendocrine origin are frequent and accuracy pretherapeutic detecting small-sized LM is questioned, but no study has compared techniques used image large specimens meticulous examination.Eleven patients metastatic endocrine tumor were...
In Brief Objectives: To evaluate the results of a vertical rectus abdominis myocutaneus (VRAM) flap after abdomino-perineal resection (APR) for anal cancer (AC). Background Data: APR is only curative treatment AC that recurs or persists radiochemotherapy. obtain clear surgical margin, frequently includes significant perineal exenteration, leaving large defect surrounded by irradiated tissue. VRAM may facilitate healing such wound and, providing tissue can cover defect, wide and thus...
Ability to identify patients with familial adenomatous polyposis who have a high risk of developing desmoid tumors may affect decisions in clinical practice.Our aim was assess several factors for tumor development an international cohort and evaluate the relevance factors.This retrospective study.Polyposis registries The Netherlands, France, Denmark, Finland, Italy provided information on tumors.We used univariate multivariable analyses data from Finland test whether gender, APC mutation...
Objective: To determine the risk factors of morbidity after surgery for ileocolonic Crohn disease (CD). Summary Background Data: The CD, particularly role anti-TNF therapy, remain controversial and have not been evaluated in a large prospective cohort study. Methods: From 2013 to 2015, data on 592 consecutive patients who underwent CD 19 French specialty centers were collected prospectively. Possible relationships between postoperative overall tested by univariate multivariate analyses....
The aim of this study was to assess results surgery for rectovaginal fistula (RVF) and prognostic factors success.Management RVF remains challenging numerous surgical options are available. Few large reports available success remain unknown.All patients operated from 1996 2014 were included.Seventy-nine presented due Crohn disease in 34 (43%), postoperative 25 (32%), obstetrical 7 (9%), radiation proctitis 4 (5%), miscellaneous 9 (11%). A total 286 procedures (132 with associated stoma, 46%)...
Immune checkpoint (ICK) expression might represent a surrogate measure of tumor-infiltrating T cell (CTL) exhaustion and therefore be more accurate prognostic biomarker for colorectal cancer (CRC) patients than CTL enumeration as measured by the Immunoscore. The ICKs, Th1, CTLs, cytotoxicity-related genes, metagenes, including Immunoscore-like were evaluated in three independent cohorts CRC samples (260 microsatellite instable [MSI], 971 non-MSI). Their associations with patient survival...
Background The magnitude and drivers of the risk serious viral infections in Inflammatory Bowel diseases (IBD) are unclear. Objective objective this study was to assess incidence factors for systemic IBD patients. Methods Using MICISTA, a database detailing prospective characteristics complications IBD, we identified patients that were followed 2005–2014 outside context organ transplantation, HIV infection or chronic hepatitis. We estimated incidences infections, defined by need...
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between gut microbiota and its host. However, factors regulating AhR within gut, which complex metabolomic environment, are poorly understood. This study investigates effect of combination metabolites on activation mechanism AhR. activity was evaluated using both luciferase reporter system mRNA levels target genes human cell lines colonic explants. studied by radioligand-binding assay, nuclear translocation...