A5079020951- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Circadian rhythm and melatonin
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Dietary Effects on Health
- Transplantation: Methods and Outcomes
- Alcohol Consumption and Health Effects
- Gastric Cancer Management and Outcomes
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- Blood groups and transfusion
- Kruppel-like factors research
- Pharmaceutical industry and healthcare
- Liver Diseases and Immunity
- Childhood Cancer Survivors' Quality of Life
- Enhanced Recovery After Surgery
- Pancreatitis Pathology and Treatment
Hôpital Paul-Brousse
2015-2025
Assistance Publique – Hôpitaux de Paris
2008-2025
Université Paris-Saclay
2020-2025
Centre Hospitalier Universitaire de Lille
2021
Inserm
2008-2020
Hôpital Claude Huriez
2016
Rockefeller University
2016
Université Paris-Sud
2000-2010
Centre Léon Bérard
2004
Centre Eugène Marquis
2004
In Brief Objective: To compare long-term outcome of R0 (negative margins) and R1 (positive liver resections for colorectal metastases (CLM) treated by an aggressive approach combining chemotherapy repeat surgery. Summary Background Data: Complete macroscopic resection with negative margins is the gold standard recommendation in surgical treatment CLM. However, due to vascular proximity or multinodularity, complete can sometimes only be performed through resection. Increasingly efficient may...
3500 Background: Despite the increasing efficacy of chemotherapy (CT) and advances in surgical techniques for initially unresectable colorectal liver metastases (uCLM), secondary resection rate remains low. For definitively uCLM, CT standard care but transplantation (LT) has shown promising results. This first randomized trial aimed to assess combined LT uCLM. Methods: Patients with uCLM from resected BRAF non mutated cancer, having responded (≥ 3 months ≤ lines) absence extrahepatic...
Chronic portal obstruction can lead to formation of cavernoma (PC). Half all patients with PC will develop cholestasis, termed biliopathy, and some progress symptomatic biliary obstruction. Because the high hemorrhage risk associated surgery in PC, optimal therapeutic strategy is controversial.Retrospective review a single hepatobiliary center experience, including 64 identified 19 concurrent Ten underwent initial treatment retroperitoneal splenorenal anastomosis. For remaining 9 patients,...
Background Prolonged use of spinal precautions in unconscious trauma patients is associated with significant morbidity. The service the John Radcliffe Hospital uses full-length radiography, computed tomographic scanning, and dynamic screening cervical spine to clear at earliest opportunity. Methods results 210 consecutive were reviewed. Seventy-eight underwent spine. Results Five these had a fracture or instability. One patient demonstrated minor changes only on plain radiography but gross...
Telemonitoring of circadian and sleep cycles could identify shift workers at increased risk poor health, including cancer cardiovascular diseases, thus supporting personalized prevention.
3561 Background: Liver transplantation (LT) has recently proved to improve the survival of selected patients with unresectable colorectal liver metastases (uCRLM) compared chemotherapy (C) alone. However, recurrence rates remain high, stressing need for a better patient selection. This exploratory study aimed identify prognostic factors associated and death in undergoing LT as part TransMet trial. Methods: Data from 36 LT+C arm (per protocol population) were analyzed including age, gender,...
1650 Background: The disruption of circadian clocks is associated with reduced survival and treatment tolerability in cancer patients (pts). Here, real-time analyses telemonitored rhythms electronic Pt-Reported Outcome (ePRO) are integrated within a multidimensional telemonitoring-telecare digital platform that triggers proactive telecare toward improved quality life (QoL) safety. Methods: multicentre, interventional, prospective, longitudinal, single-arm study recruited pts receiving...
of 24h.In mammals, the suprachiasmatic nuclei hypothalamus coordinate circadian rhythms via peripheral molecular clocks composed at least fifteen genes that are expressed in every cell.Expression these clock gene is regulated by transcription factors organized positive (BMAL1 and CLOCK) or negative (PER CRY) feedback loops.Briefly, www.aging-us.com
Background. The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the preservation duration recovery isolated perfused rat steatotic and tested pentoxifylline (PTX), known have beneficial hepatic microcirculation. Materials Methods. Fatty were obtained using diet able induce an 80% 100% microvesicular within 7 days. studied (12 hr, 18 24 hr) fatty normal liver. PTX was added University Wisconsin solution during cold...
Abstract Background The operative risk of hepatectomy under antiplatelet therapy is unknown. This study sought to assess the outcomes elective performed with or without aspirin continuation in a well balanced matched cohort. Methods Data were retrieved from multicentre prospective observational study. Aspirin and control groups compared by non-standardized methods propensity score (PS) matching analysis. main outcome was severe (Dindo–Clavien grade IIIa more) haemorrhage. Other analysed...