A5100413473- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Particle physics theoretical and experimental studies
- Neutrino Physics Research
- MicroRNA in disease regulation
- Astrophysics and Cosmic Phenomena
- Circular RNAs in diseases
- Gene expression and cancer classification
- Dark Matter and Cosmic Phenomena
- Endometrial and Cervical Cancer Treatments
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Ovarian cancer diagnosis and treatment
- Chromosomal and Genetic Variations
- Pregnancy and preeclampsia studies
- Topic Modeling
- Maternal and Perinatal Health Interventions
- Plant Stress Responses and Tolerance
- Cervical Cancer and HPV Research
- Particle Detector Development and Performance
- Gut microbiota and health
- Dietary Effects on Health
- Radiomics and Machine Learning in Medical Imaging
- Circadian rhythm and melatonin
University of South Australia
2019-2025
Lanzhou University
2022-2025
First Hospital of Lanzhou University
2025
Shanxi Academy of Building Research
2023-2025
Commonwealth Scientific and Industrial Research Organisation
2023-2025
Agriculture and Food
2025
Hebei Medical University
2018-2025
Xingtai People's Hospital
2018-2025
Peking University First Hospital
2012-2024
Peking University
2012-2024
Abstract Breast cancer is the most common type of worldwide and one major causes death in women. Epidemiological studies have established a link between night-shift work increased risk, suggesting that circadian disruption may play role carcinogenesis. Here, we aim to shed light on effect chronic jetlag (JL) mammary tumour development. To do this, use mouse model spontaneous tumourigenesis subject it disruption. We observe significantly increases cancer-cell dissemination lung metastasis. It...
Abstract Multiple SARS-CoV-2 Omicron sub-variants, such as BA.2, BA.2.12.1, BA.4, and BA.5, emerge one after another. BA.5 has become the dominant strain worldwide. Additionally, BA.2.75 is significantly increasing in some countries. Exploring their receptor binding interspecies transmission risk urgently needed. Herein, we examine capacities of human other 28 animal ACE2 orthologs covering nine orders towards S proteins these sub-variants. The affinities between hACE2 sub-variants remain...
Drought stress is one of the most important abiotic stresses which causes many yield losses every year. This paper presents a comprehensive review recent advances in international drought research. First, main types and commonly used methods current experiment were introduced, advantages disadvantages each method evaluated. Second, response plants to was reviewed from aspects morphology, physiology, biochemistry molecular progression. Then, potential improve resistance emerging technologies...
Breast cancer is one of the most prevalent malignancies and leading cause cancer‑associated mortality in women worldwide China. Everolimus (C53H83NO14) an efficient anti-cancer drug for breast which targets mammalian target rapamycin (mTOR). The present study investigated inhibitory effects everolimus on cells MCF‑7‑bearing mouse model. potential mechanism everolimus‑mediated decrease growth aggressiveness was reported. Results demonstrated that significantly inhibited cell growth, migration...
The finite-time dynamic event-triggered fuzzy output feedback fault-tolerant control problem is studied in this article for the interval type-2 (IT2) Takagi–Sugeno system with parameter uncertainties and actuator faults. A state observer first developed to solve immeasurable problem. Second, by using sampled estimating states measured signals, a mechanism formulated via integrating sensor-to-observer observer-to-controller. Third, an observer-based controller synthesized nonparallel...
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) has been studied to be involved in the development and progression of several human malignancies.However, little is unveiled regarding complex mechanisms TNFRSF11B gastric cancer (GC).The clinical significance was assessed 70 160 GC tissues using immunohistochemistry method gene microarray analysis, respectively.The biological function vitro vivo assays.Immunofluorescence assay used evaluate expression β-catenin nucleus.The...
Randomly distributed topological defects created during the spontaneous symmetry breaking are fingerprints to trace evolution of symmetry, range interaction, and order parameters in condensed matter systems. However, effective mean manipulate into ordered form is elusive due protection. Here, we establish a strategy effectively align domain networks hexagonal manganites through mechanical approach. It found that nanoindentation strain gives rise threefold Magnus-type force distribution,...
Long noncoding RNA muskelin 1 antisense (MKLN1-AS) acted as an oncogenic regulator in hepatocellular carcinoma (HCC). This study was performed to investigate the functional mechanism of MKLN1-AS. MKLN1-AS, microRNA-22-3p (miR-22-3p) and ETS Proto-Oncogene (ETS1) levels were examined using reverse transcription-quantitative polymerase-chain reaction. Protein expression detected by Western blot. The target relation analyzed dual-luciferase reporter assay, immunoprecipitation assay pull-down...
// Jianmei Wang 1, 3, * , Xiaohui Zhu 2, Jinlong Hu 2 Guoyang He Xiaomei Li Pingxiang Wu Xiaoli Ren Feifei Wenting Liao Liang Yanqing Ding 1 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, People's Republic China Province Key Laboratory Molecular Tumor 3 The Affiliated Hospital Luzhou College, 646000, Luzhou, These authors have contributed equally to this work Correspondence to: Ding, e-mail: dyq@fimmu.com Liang,...
Background: Long COVID, or Post–Acute Sequelae of COVID–19 (PASC), involves persistent, multisystemic symptoms in about 10–20% COVID-19 patients. Although age, sex, ethnicity, and comorbidities are recognized as risk factors, identifying genetic contributors is essential for developing targeted therapies. Methods: We developed a multi–omics framework using Transcriptome-Wide Mendelian Randomization (TWMR) Control Theory (CT). This approach integrates Expression Quantitative Trait Loci...
Colorectal cancer (CRC) is one of the most detrimental tumors to human health. Although multimodal therapeutic approaches can improve patient survival rates, prognosis for advanced-stage patients remains poor. It has been reported that family with sequence similarity 60, member A (FAM60A), a component SIN3 transcription regulator (SIN3A)/histone deacetylase (HDAC) complex, plays significant role in tumorigenesis. However, precise function and mechanisms action FAM60A CRC have not fully...
The Mpox virus (MPXV) is an orthopoxvirus that caused a global outbreak in 2022. poxvirus DNA polymerase complex responsible for the replication and integrity of viral genome; however, molecular mechanisms underlying fidelity are still unclear. In this study, we determined cryoelectron microscopy (cryo-EM) structures MPXV F8-A22-E4 holoenzyme its editing state, with mismatched primer-template containing uracil deoxynucleotide. We showed has similar replication-to-edit transition mechanism to...
Following the publication of this paper, it was drawn to Editors' attention by a concerned reader that Transwell migration and invasion assay data shown in Fig. 3E F on p. 7166 were strikingly similar appearing different form other articles written authors at research institutes had already been published elsewhere prior submission paper <em>Molecular Medicine Reports</em>. In view fact abovementioned apparently previously, Editor Reports</em> has decided should be retracted from Journal....
Genome annotation is critical for understanding functional elements within genomes. Manual curation a common practice identifying the functions of genes, particularly those missed by automated pipelines. However, this process notoriously labour-intensive and time-consuming. In response to these challenges, we present GeneWhisperer, an innovative assistant system designed facilitate manual gene process. Utilizing large language model (LLM) agent, GeneWhisperer provides users access tools...
Long COVID, also referred to as post-acute sequelae of COVID-19 (PASC), is a substantial global health concern estimated have affected over 145 million individuals worldwide. Characterized by persistent and new symptoms extending beyond four weeks from the initial infection–such fatigue, breathlessness, cognitive impairments–Long COVID poses significant challenges healthcare systems due its chronic nature diverse clinical manifestations. An urgent need exists elucidate underlying mechanisms...
Despite the exciting progress of bifunctional degrader molecules, also known as proteolysis-targeting chimeras (PROTACs), rapidly expanding field is still significantly hampered by lack available E3 ligase ligands. Our research bridges this gap uncovering a series small-molecule ligands to TRIM21 through DNA-Encoded Library (DEL) technology. We confirmed their interaction with using crystallography and demonstrated antiproliferative effects across various cancer cell types. Furthermore,...