A5024806945- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Pluripotent Stem Cells Research
- Ectopic Pregnancy Diagnosis and Management
- Advanced Mathematical Modeling in Engineering
- Neonatal Respiratory Health Research
- Endometriosis Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Nonlinear Partial Differential Equations
- Gestational Diabetes Research and Management
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Stability and Controllability of Differential Equations
- CRISPR and Genetic Engineering
- Pregnancy-related medical research
- Renal and related cancers
- Thyroid Cancer Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Electrochemical Analysis and Applications
- Retinal Diseases and Treatments
- Cancer-related gene regulation
- RNA modifications and cancer
Third Affiliated Hospital of Guangzhou Medical University
2016-2025
Guangzhou Medical University
2016-2025
Community Link
2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Yangzhou University
2025
Key Laboratory of Guangdong Province
2015-2024
Fujian Agriculture and Forestry University
2022-2024
Guangzhou Women and Children Medical Center
2024
Shenzhen University
2024
Successful pregnancy involves the homeostasis between maternal decidua and fetoplacental units, whose disruption contributes to compromised outcomes, including recurrent spontaneous abortion (RSA). The role of cell heterogeneity in RSA is yet be illustrated.A total 66,078 single cells from samples isolated patients with healthy controls were analysed by unbiased single-cell RNA sequencing (scRNA-seq).Our scRNA-seq results revealed that stromal are most abundant type during early pregnancy....
Preeclampsia is one of the most common severe pregnancy complications in obstetrics, which considered a placental source disease. However, mechanisms underlying preeclampsia remain largely unknown. In this study, UPLC-MS/MS-based metabolomic and lipidomic analysis was used to explore characteristic metabolites preeclampsia. The results revealed that there were significant changes between normotensive placentas. Weighted correlation network (WGCNA) identified module highly related clinical...
Abstract Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet underlying regulatory mechanisms remain elusive. Here, we show that specific deletion Kat8 , a MYST family histone acetyltransferase, leads to extraembryonic ectoderm abnormalities embryonic lethality. Employing RNA-seq CUT&Tag analyses on stem cells (TSCs), further discover KAT8 regulates transcriptional activation stemness marker, CDX2, via acetylating H4K16....
Inhibition of lipoprotein-associated phospholipase A2 (Lp-PLA2) has been suggested to be a promising therapeutic strategy for several inflammation-associated diseases, including atherosclerosis, Alzheimer's disease, and diabetic macular edema. Herein, we report the discovery novel series Lp-PLA2 inhibitors constructed on an imidazo[1,2-a]pyrimidine scaffold through conformational restriction strategy. Structure-activity relationship (SAR) analysis resulted in identification compounds with...
Human uterine stromal cell undergoes decidualization for pregnancy establishment and maintenance, which involved extensive proliferation differentiation. Increasing studies have suggested that recurrent spontaneous abortion (RSA) may result from defective endometrial decidualization. However, the critical molecular mechanisms underlying impaired during RSA are still elusive. By using our recently published single-cell RNA sequencing (scRNA-seq) atlas, we found MYC-associated factor X (MAX)...
Abstract Objectives The impacts of the current COVID‐19 pandemic on maternal and foetal health are enormous serious concern. However, influence SARS‐CoV‐2 infection at early‐to‐mid gestation remains unclear. Materials methods Here, we report follow‐up study a pregnant woman her whole infective course SARS‐CoV‐2, from asymptomatic gestational week 20 to mild then severe illness state, finally cured Week 24. Following caesarean section due incomplete uterine rupture 28, histological...
Abstract The initial stage of rice blast fungus, Magnaporthe oryzae , infection, before 36 h postinoculation, is a critical timespan for deploying pathogen effectors to overcome the host's defences and ultimately cause disease. However, how this process regulated at transcription level remains largely unknown. This study functionally characterized two M . Early Infection‐induced Transcription Factor genes ( MOEITF1 MOEITF2 ) analysed their roles in process. Target gene deletion mutant...
In this paper, we consider a free boundary problem of two-phase inviscid incompressible fluid in gravity field. The presence the field induces novel phenomena that there might be some stagnation points on surface flow, where velocity vanishes. From mathematical point view, gradient stream function degenerates near point, leading to singular behaviors surface. primary objective study is investigate singularity and regularity surface, considering their mutual interaction between two fluids...