A5060274923- Nanomaterials for catalytic reactions
- Pharmacological Effects of Natural Compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Analytical Chemistry and Chromatography
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Catalytic Processes in Materials Science
- Advanced biosensing and bioanalysis techniques
- Covalent Organic Framework Applications
- Pharmacological Effects and Toxicity Studies
- Metabolomics and Mass Spectrometry Studies
- Catalysis and Hydrodesulfurization Studies
- Analytical chemistry methods development
- Enzyme Catalysis and Immobilization
- Chromatography in Natural Products
- Gut microbiota and health
- Epilepsy research and treatment
- Molecular Sensors and Ion Detection
- Nanoparticle-Based Drug Delivery
- Ammonia Synthesis and Nitrogen Reduction
- Ginger and Zingiberaceae research
- Catalysis for Biomass Conversion
- Herbal Medicine Research Studies
- Renal cell carcinoma treatment
- MXene and MAX Phase Materials
Xuzhou Medical College
2016-2025
Nanjing Tech University
2016-2025
Tsinghua University
2021-2025
Nanyang Institute of Technology
2022-2024
Henan University
2024
Nanjing University
2023-2024
State Key Laboratory of Pharmaceutical Biotechnology
2023-2024
Shanxi Medical University
2006-2024
Ningbo University
2022-2023
Beijing Sport University
2023
Gut microbiota plays a key role in the pathophysiology of type 2 diabetes mellitus (T2D). Mulberry leaf has hypoglycemic effect, but potential mechanism is not fully understood. This study aimed to explore influences and mechanisms mulberry water extract (MLWE) intervention on mice with T2D induced through high-fat high-sucrose diet combined streptozotocin by combination fecal metabolomics gut analysis. Results showed that MLWE could decrease fasting blood glucose body weight while...
Abstract Elevations in circling branched‐chain amino acids (BCAAs) levels associated with insulin resistance and type 2 diabetes mellitus (T2DM). Morus alba L. water extracts (MLE) show hypoglycemic function, but the precise mechanism remains obscure. This study is designed to investigate association of antidiabetes effect MLE BCAAs co‐metabolism modulated by host gut microbiota. Tissue‐specific expressions BCAA‐catabolizing enzymes were detected RT‐PCR western blot, respectively. The...
Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate residues. It reported to be present in all life forms. Experimental studies showed that polyP plays important roles bacterial durability and virulence. Here we investigated the relationships with virulence theoretically. Bacterial lifestyle, environmental persistence, factors, species evolution are included analysis. The presence seven genes involved metabolism (ppk1, ppk2, pap, surE, gppA, ppnK, ppgK) 2595 core factors...
Transaminases show potential for the industrial synthesis of important pharmaceutical ingredients. However, these naturally occurring enzymes poor activity toward bulky N-heterocyclic compounds. To produce a catalyst with enhanced catalytic efficiency, this study redesigned an (R)-selective transaminase from Rhodobacter sp. 140A (RbTA). Key residues substrate binding were identified by molecular docking and dynamics simulations. A "simplified amino acid alphabet," consisting acids different...
Glycogen, a randomly branched glucose polymer, provides energy storage in organisms. It forms small β particles which animals bind to form composite α particles, give better release. Simulations imply particle size is controlled only by activities and sizes of glycogen biosynthetic enzymes polymer chains. Thus, storing more requires forming are expected sometimes particles. No have been reported bacteria, but the extraction techniques might caused degradation. Using milder on Escherichia...
Traditionally, the quality evaluation of Chrysanthemum morifolium (CM) cv. (Juhua) attributes its habitats and processing methods, however, this strategy neglecting bioactive ingredients usually results in deviation evaluation. This study aims to explore marker (Q-marker) based on spectrum-effect relationship control CMs. The chromatographic fingerprint 30 flower head samples CMs from five different including Hang-baiju, Gongju, Huaiju, Taiju Boju were constructed by high performance liquid...
A molecularly imprinted polymer membrane (MIPM) was prepared using PVDF as the support and phenytoin (PHT) a single template. The results indicated that MIPMs can be used to extract PHT, phenobarbital, lamotrigine in different matrices.