A5100342087- Cannabis and Cannabinoid Research
- Fatty Acid Research and Health
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Sexual Differentiation and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Enzyme Catalysis and Immobilization
- Pregnancy and preeclampsia studies
- Cancer, Hypoxia, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Thyroid Disorders and Treatments
- Tryptophan and brain disorders
- Asthma and respiratory diseases
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Growth Hormone and Insulin-like Growth Factors
- Natural product bioactivities and synthesis
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
Third Affiliated Hospital of Guangzhou Medical University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Guangzhou Medical University
2018-2024
Stomatology Hospital
2024
Sichuan University
2022-2024
China Medical University
2010-2024
Xiamen University
2009-2024
University of California, Irvine
2021-2024
Royal Netherlands Academy of Arts and Sciences
2024
University Medical Center Utrecht
2024
Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity mortality, recurrent thrombosis is common despite current optimal therapy. Protein disulfide isomerase (PDI) an oxidoreductase that has recently been shown to participate in thrombus formation. While currently available antithrombotic agents inhibit either platelet aggregation fibrin generation, inhibition secreted PDI blocks the earliest stages suppressing both pathways. Here, we explored extracellular...
Lipoid congenital adrenal hyperplasia is a severe disorder of and gonadal steroidogenesis caused by mutations in the steroidogenic acute regulatory protein (StAR). Affected children typically present with life-threatening insufficiency early infancy due to failure glucocorticoid (cortisol) mineralocorticoid (aldosterone) biosynthesis, 46,XY genetic males have complete lack androgenization appear phenotypically female impaired testicular androgen secretion utero.The objective this study was...
Familial glucocorticoid deficiency (FGD) is an autosomal recessive disorder resulting from resistance to the action of ACTH on adrenal cortex. Affected individuals are deficient in cortisol and, if untreated, likely succumb hypoglycemia and/or overwhelming infection. Mutations receptor (MC2R) and melanocortin 2 accessory protein (MRAP), FGD types 1 respectively, account for approximately 45% cases.A locus chromosome 8 has previously been linked disease three families, but no underlying gene...
The purpose of this study was to use metabonomic profiling identify a potential specific biomarker pattern in urine as noninvasive bladder cancer (BC) detection strategy. A liquid chromatography-mass spectrometry based method, which utilized both reversed phase chromatography and hydrophilic interaction separations, performed, followed by multivariate data analysis discriminate the global profiles 27 BC patients 32 healthy controls. Data from columns were combined, combination proved be...
The main purpose of this study was to investigate the effects exercise intensity and frequency on anxiety, depression sleep quality in college students.All participants came from a university northeastern China. All were tested for Diagnostic Statistical Manual Mental Disorders (DSM-5) diagnosed with anxiety disorders. research subjects divided into six groups, namely low-intensity low-frequency group (group 1), moderate-frequency 2), high-frequency 3), high-intensity 4), 5) 6). duration...
Background/Aim Depression has become a multiple disease worldwide, and is closely related to the systemic inflammatory response. Methods Based on data of National Health Nutrition Examination Survey (NHANES), this study included 2,514 depressive 26,487 non-depressive adults. The immune-inflammation index (SII) inflammation response (SIRI) were used quantify inflammation. multivariate logistic regression inverse probability weighting methods analyze effect size SII SIRI risk depression....
By using the large cytoplasmic domain of nicotinic acetylcholine receptor (AChR) α4 subunit as a bait in yeast two-hybrid system, we isolated first cytosolic protein, 14-3-3η, known to interact directly with neuronal AChRs. 14-3-3η is member family proteins that function regulatory or chaperone/ scaffolding/adaptor proteins. interacted recombinant alone tsA 201 cells following activation cAMP-dependent protein kinase by forskolin. The interaction subunits was abolished when serine 441...
Hypospadias is a frequent congenital anomaly but in most cases an underlying cause not found. Steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) key regulator of human sex development and increasing number SF-1 (NR5A1) mutations are reported 46,XY disorders (DSD). We hypothesized that NR5A1 could be identified boys with hypospadias.Mutational analysis 60 individuals varying degrees hypospadias from the German DSD network.Heterozygous were found three out cases. These represented severe end spectrum...
<h3>PURPOSE</h3> We examined the effects of participating in a "train-the-trainer" program and being peer supporter on metabolic cognitive/psychological/behavioral parameters Chinese patients with type 2 diabetes. <h3>METHODS</h3> In response to our invitation, 79 fair glycemic control (HbA<sub>1c</sub> <8%) agreed participate become supporters. Of 59 who completed successfully, 33 be supporters ("agreed trainees") were each assigned support 10 for 1 year, voluntary extension period 3...
In this study, a low molecular-weight (Mw) peptide named NJP (<1 kDa), was purified from protein hydrolysate of
The calcium sensor protein visinin-like protein-1 (VILIP-1) was isolated from a brain cDNA yeast two-hybrid library using the large cytoplasmic domain of α4 subunit as bait. VILIP-1 is myristoylated that contains three functional binding EF-hand motifs. residues 302–339 were found to be essential for interaction with VILIP-1. coimmunopurified detergent-solubilized recombinant α4β2 acetylcholine receptors (AChRs) expressed in tsA201 cells and native AChRs brain. Coexpression up-regulated...