A5100452136- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
- Neurotransmitter Receptor Influence on Behavior
- Genetic and phenotypic traits in livestock
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Neural dynamics and brain function
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Olfactory and Sensory Function Studies
- Cancer Research and Treatments
- Adenosine and Purinergic Signaling
- Sleep and Work-Related Fatigue
- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
- Regulation of Appetite and Obesity
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
Zhejiang University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Second Affiliated Hospital of Zhejiang University
2019-2025
Zhejiang Lab
2022-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2025
Brain (Germany)
2025
Jiangsu Agri-animal Husbandry Vocational College
2021-2024
Qiqihar Medical University
2023
State Key Laboratory of Modern Optical Instruments
2022
North China University of Science and Technology
2022
γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-cells. However, in humans it is unknown whether can increase β-cell mass improve glucose homeostasis. To address this question, we transplanted a suboptimal of human islets into immunodeficient NOD-scid-γ mice with streptozotocin-induced diabetes. GABA treatment increased grafted proliferation, while decreasing apoptosis, leading to enhanced mass. This was associated circulating insulin reduced glucagon...
The amygdala, or an amygdala-like structure, is found in the brains of all vertebrates and plays a critical role survival reproduction. However, cellular architecture amygdala how it has evolved remain elusive. Here, we generated single-nucleus RNA-sequencing data for more than 200,000 cells humans, macaques, mice, chickens. Abundant neuronal cell types from different subnuclei were identified datasets. Cross-species analysis revealed that inhibitory neurons neuron-enriched well-conserved...
Abstract The circadian clock regulates animal physiological activities. How temperature reorganizes circadian-dependent activities remains elusive. Here, using in-vivo two-photon imaging with the control device, we investigated response of Drosophila central circuit to variation and identified that DN1as serves as most sensitive temperature-sensing neurons. gate DN1a’s diurnal response. Trans-synaptic tracing, connectome analysis, functional data reveal bidirectionally targets two neuronal...
Background: Little is known about the molecular genetic events that contribute to pathogenesis of squamous cell carcinoma upper aerodigestive tract. Previous studies have been limited identification mutations p53 (also as TP53) tumor suppressor gene, activation a set oncogenes, allelic loss at 3p and other locations, occasional association with human papillomavirus infection. Purpose : Our purpose was screen tissue blood from patients tract for heterozygosity polymorphic loci corresponding...
Cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (REM) sleep arousal. Using transgenic mice which channelrhdopsin-2 is selectively expressed cholinergic neurons, we show that optical stimulation of inputs thalamic reticular nucleus (TRN) activates local GABAergic neurons promote protect non-rapid (NREM) sleep. It does not affect REM Instead, direct activation input TRN shortens time onset generates spindle oscillations...
The proteasome plays a central role in maintaining cellular homeostasis, controlling the cell cycle, removing misfolded proteins that can be toxic, and regulating immune system. It is also an important target for novel anticancer drugs, such as bortezomib, potent inhibitor has been used successfully treatment of multiple myeloma. Here, we show antimalaria drug chloroquine inhibits function eukaryotic extracts preparations purified 20S archaeal from Thermoplasma acidophilium....
Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for P2Y6 mediators phagocytosis. However, pinocytosis, known the internalization of fluid-phase materials, has received much less attention. We found that ATP efficiently triggered pinocytosis in microglia. Pharmacological analysis knockdown experiments demonstrated...
Disturbed development of the parvalbumin-positive fast-spiking (FS) interneurons in prefrontal cortex (PFC) is closely associated with many neuropsychiatric disorders such as schizophrenia and autism. FS form at least 2 microcircuits PFC: one pyramidal neurons (FS–PN) through chemical synapses; other (FS–FS) via electrical synapses. It currently unknown when how these circuits are established PFC during early development. Here, we used G42 mice, which specifically labeled enhanced green...
Abstract The amygdala, which is involved in various behaviors and emotions, reported to connect with the whole brain. However, long-range inputs of distinct cell types have not yet been defined. Here, we used a retrograde trans-synaptic rabies virus generate whole-brain map main mouse amygdala. We identified 37 individual regions that projected neurons expressing vesicular glutamate transporter 2, 78 parvalbumin-expressing neurons, 104 protein kinase C-δ, 89 somatostatin-expressing neurons....
Abstract The amygdaloid complex consists of multiple nuclei and is a key node in controlling temporal lobe epilepsy (TLE) both human animal model studies. However, the specific nucleus neural circuitry governing seizures remain unknown. Here, it discovered that activation glutamatergic neurons posterior basolateral amygdala (pBLA) induces severe even mortality. pBLA project collateral connections to brain regions, including insular cortex (IC), bed stria terminalis (BNST), central (CeA)....