A5021020327- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Saffron Plant Research Studies
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Enhanced Recovery After Surgery
- Lipid metabolism and biosynthesis
- Advanced Glycation End Products research
- Immune Response and Inflammation
- Hedgehog Signaling Pathway Studies
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Surgical site infection prevention
Henan Agricultural University
2012-2025
Hangzhou Medical College
2017-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Zhejiang Provincial People's Hospital
2024
Fuyang City People's Hospital
2022
Nanjing Medical University
2018-2022
Nanjing Drum Tower Hospital
2021-2022
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
High Magnetic Field Laboratory
2016-2020
Increasing evidence has implicated the membrane protein CD36 (FAT) in binding and transport of long chain fatty acids (FA). To determine physiological role CD36, we examined effects its overexpression muscle, a tissue that depends on FA for energy needs is responsible clearing major fraction circulating FA. Mice with muscle were generated using promoter creatine kinase gene (MCK). Transgenic (MCK-CD36) mice had slightly lower body weight than control litter mates. This reflected leaner mass...
Age-related long-term disability is attracting increasing attention due to the growing ageing population worldwide. However, current understanding of senescent spinal cord remains insufficient. Bulk RNA sequencing reveals that 526 genes are upregulated and 300 downregulated in cords. Pathway enrichment analysis differentially expressed shows senescence cords related phagosome function, neuroinflammation, ferroptosis, necroptosis. Prediction upstream transcription factors interactome identify...
MicroRNA (miRNA) are small single-stranded noncoding RNA with important roles in regulating innate immunity nonruminants via transcriptional and posttranscriptional mechanisms. Mastitis causes significant losses the dairy industry a wealth of large-scale mRNA expression data from mammary tissue have provided fundamental insights into adaptations to pathogens. We studied 14 miRNA (miR-10a, -15b, -16a, -17, -21, -31, -145, -146a, -146b, -155, -181a, -205, -221, -223) associated regulation...
Alphaherpesvirus infection results in severe health consequences a wide range of hosts. USPs are the largest subfamily deubiquitinating enzymes that play critical roles immunity and other cellular functions. To investigate role alphaherpesvirus replication, we assessed 13 USP inhibitors for PRV replication. Our data showed all tested compounds inhibited with USP14 inhibitor b-AP15 exhibiting most dramatic effect. Ablation also influenced whereas replenishment null cells restored viral...
Abstract Anticancer agent FL118 was recently identified in screening of small-molecule inhibitors human survivin expression. Although is a camptothecin analogue, its antitumor potency much superior to other FDA-approved analogues (irinotecan and topotecan). The mechanism action (MOA) underlying the effects remains be fully elucidated. Here, we report that activates tumor suppressor p53 as novel MOA wild-type cancer cells. Our studies show this involves an induction proteasomal degradation...
Cardiac hypertrophy can cause heart failure. However, the mechanisms underlying progression of cardiac remain unclear. Emerging evidence suggests that circular RNAs (circRNAs) play a critical role in hypertrophy. association between circ_nuclear factor I X (circNfix) and largely unknown. Therefore, aim present study was to explore circNfix In order detect function hypertrophy, cardiomyocytes were stimulated with angiotensin II (Ang II) mimic pathogenesis disease. addition, pressure...
Saffron, a traditional Chinese medicine, is derived from Crocus sativus L. stigmas and has been reported to possess neuroprotective properties potentially contribute the inhibition of apoptosis inflammation. Safranal, potent monothyral aldehyde, main component saffron that have antiepileptic activity. However, specific mechanism by which safranal suppresses epileptic seizures via its antiapoptotic anti-inflammatory unclear.
Neuroinflammation is considered as one of the common pathogeneses depression. Huanglian‐Jie‐Du‐Tang (HJDT) a traditional Chinese herbal formula. The present study investigates antidepressant‐like effect HJDT and its possible mechanism in rats. Rats were given (2, 4, 8 g/kg, intragastrically), paroxetine (1.8 mg/kg, or an equivalent volume saline for 42 days. depression‐related behaviors, including sucrose preference test (SPT), open field (OFT), novel objective recognition task (NORT),...
Background and Purpose There is emerging evidence suggesting that abnormal transport of amyloid‐β (Aβ) across the blood–brain barrier (BBB) involved in diabetes‐associated cognitive decline. We investigated whether PPARγ agonists restore Aβ BBB hippocampal plasticity db / mice. Experimental Approach Efflux influx were determined by stereotaxic intra‐cerebral or i.a. infusion [ 125 I]‐Aβ 1–40 respectively. Receptor for advanced glycation end products (RAGE) low‐density lipoprotein...
Pseudorabies virus (PRV) is a double-stranded DNA that causes Aujeszky's disease and responsible for economic loss worldwide. Transmembrane protein 41B (TMEM41B) novel endoplasmic reticulum (ER)-localized regulator of autophagosome biogenesis lipid mobilization; however, the role TMEM41B in regulating PRV replication remains undocumented. In this study, infection was found to upregulate mRNA levels both vitro vivo. For first time, we could be induced by interferon (IFN), suggesting an...
The present study was designed to determine whether low-frequency stimulation (LFS) of the entorhinal cortex(EC) has an anticonvulsive effect, and LFS delivered at different times plays roles. We found that EC immediately or 4 s after kindling had latter a better effect on both kindled seizures. However, cessation afterdischarge 10 stimulation, augmented epileptic activity. So is potential target for interfere with epilepsy. Our findings suggest even in duration afterdischarge, there exists...
Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation drive Alzheimer disease (AD) pathology. By regulating vascular functions inflammation in the microvasculature, a disintegrin metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) plays significant protective effect atherosclerosis stroke. However, whether ADAMTS13 influences AD pathogenesis remains unclear. Using vivo multiphoton microscopy, histological,...
The lack of effective tumor-associated antigens restricts the development targeted therapies against myeloid leukemia. In this study, we compared gene expression patterns acute leukemia (AML) and normal bone marrow samples found that epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in patients with AML, EpCAM+ leukemic cells exhibiting enhanced chemoresistance oncogenesis. chemotherapeutic resistance EpCAM-positive a consequence increased WNT5B signaling. Furthermore,...
Abstract Classical swine fever virus (CSFV) is a single‐stranded RNA flavivirus that can cause serious diseases in porcine species, including symptoms of infarction, systemic hemorrhage, high fever, or depression. Viperin an important interferon‐inducible antiviral gene has been shown to inhibit CSFV, but the exact mechanisms by which it able do so remain poorly characterized. In present study, we determined CSFV infection led viperin upregulation PK‐15 cells (porcine kidney cell). When was...