A5042515876- SARS-CoV-2 and COVID-19 Research
- Peroxisome Proliferator-Activated Receptors
- Computational Drug Discovery Methods
- Genomics and Phylogenetic Studies
- Synthesis and biological activity
- Adipose Tissue and Metabolism
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Tuberculosis Research and Epidemiology
- Synthesis and Characterization of Heterocyclic Compounds
- Drug Transport and Resistance Mechanisms
- Mycobacterium research and diagnosis
- Metabolism and Genetic Disorders
- Antimicrobial Resistance in Staphylococcus
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Bacterial biofilms and quorum sensing
- Genomics and Rare Diseases
- Lipid metabolism and biosynthesis
- Antibiotic Resistance in Bacteria
- vaccines and immunoinformatics approaches
- Plant Pathogenic Bacteria Studies
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
Mohammed V University
2016-2025
Université Mohammed VI des Sciences de la Santé
2022-2024
Hôpital Militaire Moulay Ismail
2024
Centre de Recherche en Cancérologie de Toulouse
2024
Inserm
2024
University of Health Science
2023
University of Health Sciences
2023
Biotechnology Research Center
2022
Bioinova (Czechia)
2022
Medical University of Lodz
2021
SARS-CoV-2 across Africa The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been hard to track in African countries, largely because patchy data. Wilkinson et al . curated viral genomes collected 2021 from several countries continent. Outbreaks during 2020 each country were initiated by imported cases, mostly Europe. As developed, case numbers likely many times higher than reported, and subsequent waves appear have more severe. Consequently,...
Increasing evidence has implicated the membrane protein CD36 (FAT) in binding and transport of long chain fatty acids (FA). To determine physiological role CD36, we examined effects its overexpression muscle, a tissue that depends on FA for energy needs is responsible clearing major fraction circulating FA. Mice with muscle were generated using promoter creatine kinase gene (MCK). Transgenic (MCK-CD36) mice had slightly lower body weight than control litter mates. This reflected leaner mass...
In mammalian cells, membrane uptake of long-chain fatty acids is mediated by two separate components; a passive component that linear function the concentration free acid in extracellular medium and saturable exhibits characteristics protein-facilitated process. This review summarizes body work has accumulated related to mechanism transport. Evidence support facilitated process presented with relation different cell types or systems where it was collected. The evidence includes saturation...
An adipocyte membrane glycoprotein, (FAT), homologous to human CD36, has been previously implicated in the binding/transport of long-chain fatty acids. It bound reactive derivatives acids and binding was specific associated with significant inhibition acid uptake. Tissue distribution protein regulation its expression were also consistent postulated role. In this report, we have examined effects FAT on rates properties uptake by Ob17PY fibroblasts lacking protein. Three clones (P21, P22, P25)...
The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping sequencing improved data analysis capabilities. Some the greatest genetic diversity among humans, animals, plants, microbiota occurs Africa, yet genomic outputs from continent are limited. Human Heredity Health Africa (H3Africa) initiative was established drive development for human health through recognition critical role bioinformatics...
In late December 2019, an emerging viral infection COVID-19 was identified in Wuhan, China, and became a global pandemic. Characterization of the genetic variants SARS-CoV-2 is crucial following evaluating it spread across countries. this study, we collected analyzed 3,067 genomes isolated from 55 countries during first three months after onset virus. Using comparative genomics analysis, traced profiles whole-genome mutations compared frequency each mutation studied population. The...
The COVID-19 pandemic has been ongoing since its onset in late November 2019 Wuhan, China. Understanding and monitoring the genetic evolution of virus, geographical characteristics, stability are particularly important for controlling spread disease especially development a universal vaccine covering all circulating strains. From this perspective, we analyzed 30,983 complete SARS-CoV-2 genomes from 79 countries located six continents collected 24 December 2019, to 13 May 2020, according...
We have examined whether 1) fatty acid (FA) uptake, 2) FA transporter expression, and 3) metabolism are increased when the oxidative capacity of skeletal muscle is increased. The capacities red white tibialis anterior extensor digitorum longus muscles were via chronic stimulation (10 Hz, 24 h/day for 7 days). contralateral served as controls. After days activity palmitate uptake by giant sarcolemmal vesicles was twofold ( P < 0.05), expression translocase (FAT)/CD36 at both mRNA (3.2- to...
In diabetic rodents, thiazolidinediones are able to improve insulin sensitivity of target tissues and reverse, at least partially, the state. The effects these drugs on phenotypic expression in various tissues, including adipose tissue, have been reported. We report here that a new thiazolidinedione compound, BRL 49653, exerts, preadipose cells, potent genes encoding proteins involved fatty acid metabolism. These 49653 Ob 1771 cells similar, terms kinetics, reversibility, specificity...
The global burden of infections and the rapid spread viral diseases show need for new approaches in prevention development effective therapies. To this end, we aimed to explore novel inhibitor compounds that can stop replication or decrease load severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which there is currently no approved treatment. Besides using angiotensin-converting enzyme (ACE2) receptor as a main gate, CoV-2 bind glucose-regulating protein 78 (GRP78) get into cells...
Abstract Background Rahnella perminowiae S11P1 and Variovorax sp. S12S4 are two plant growth-promoting rhizobacteria that were previously isolated from the rhizosphere of Crocus sativus L. (saffron), have demonstrated interesting PGP activities promising results when used as inoculants in field trials. To further elucidate molecular mechanisms underlying their beneficial effects on growth, comprehensive genome mining comparative genomic analysis with closely related strains conducted....
Abstract In late December 2019, an emerging viral infection COVID-19 was identified in Wuhan, China, and became a global pandemic. Characterization of the genetic variants SARS-CoV-2 is crucial following evaluating it spread across countries. this study, we collected analyzed 3,067 genomes isolated from 55 countries during first three months after onset virus. Using comparative genomics analysis, traced profiles whole-genome mutations compared frequency each mutation studied population. The...
Long-chain fatty acid uptake, which provides a large part of myocardial energy, is impaired in human and murine hearts deficient the membrane translocase, FAT/CD36. We examined function CD36-null mice using working heart. Fatty oxidation stores glycogen, triglycerides, ATP were reduced CD36-deficient restored to WT levels by rescue myocyte CD36. Under normal perfusion conditions, had similar cardiac outputs end-diastolic pressures as or transgenic hearts. After 6 min ischemia, output...