A5054654748- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Child Nutrition and Water Access
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Parasites and Host Interactions
- Viral Infections and Vectors
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Research on Leishmaniasis Studies
- Vaccine Coverage and Hesitancy
- Insect Pest Control Strategies
- HIV/AIDS Research and Interventions
- Cancer-related Molecular Pathways
- HIV, Drug Use, Sexual Risk
- Computational Drug Discovery Methods
- Healthcare Systems and Practices
- Machine Learning in Bioinformatics
- Disaster Response and Management
- Autism Spectrum Disorder Research
- Cancer Genomics and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
Université des Sciences, des Techniques et des Technologies de Bamako
2016-2025
University of Bamako
2015-2024
National Institute of Malaria Research
2011-2023
Centre for Human Genetics
2023
University of Oxford
2023
Columbia University
2022
Bordeaux Population Health
2022
Université Claude Bernard Lyon 1
2022
Institut Bergonié
2022
University of Sierra Leone
2022
H3Africa is developing capacity for health-related genomics research in Africa
<ns3:p>We describe the MalariaGEN Pf7 data resource, seventh release of <ns3:italic>Plasmodium falciparum</ns3:italic> genome variation from network. It comprises over 20,000 samples 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For first time we include dried blood spot sequenced after selective whole amplification, necessitating new methods to genotype copy number variations. We identify a large newly emerging...
Based on highly successful demonstrations in Israel that attractive toxic sugar bait (ATSB) methods can decimate local populations of mosquitoes, this study determined the effectiveness ATSB for malaria vector control semi-arid Bandiagara District Mali, West Africa. Control and treatment sites, selected along a road connects villages, contained man-made ponds were primary larval habitats Anopheles gambiae arabiensis. Guava honey melons, two fruits shown to be An. s.l., used prepare solutions...
The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping sequencing improved data analysis capabilities. Some the greatest genetic diversity among humans, animals, plants, microbiota occurs Africa, yet genomic outputs from continent are limited. Human Heredity Health Africa (H3Africa) initiative was established drive development for human health through recognition critical role bioinformatics...
Immunity to sand fly salivary protein correlates protection against cutaneous leishmaniasis in rhesus macaques.
Abstract Background The aim of this field trial was to evaluate the efficacy attractive toxic sugar baits (ATSB) in Mali, where sustained malaria transmission occurs despite use long-lasting insecticidal nets (LLINs). ATSB bait stations were deployed seven 14 similar study villages, LLINs already widespread use. combined and tested see if it would substantially reduce parasite by Anopheles gambiae sensu lato beyond alone. Methods A 2-day experiment conducted determine number mosquitoes...
Seventy-nine taxa of Pyraloidea were collected in 2014 with light traps the woody savannah zone south Bamako, Mali. Three out 79 identified to genus level only. 78 species are new records for Mali, 17 West Africa. Most (54) belong subfamily Spilomelinae (family Crambidae). The majority observed have wide distribution areas. only regional endemic is Hypsopygia bamakoensis (Leraut, 2006). Concerning biogeographical categories most (34) Afrotropical, seven cosmopolitan, and remaining occur...
Attractive toxic sugar bait (ATSB) solutions containing any gut toxins can be either sprayed on plants or used in simple stations to attract and kill sugar-feeding female male mosquitoes. This field study Mali demonstrates the effect of ATSB inside houses as a vector control method that targets kills endophilic African malaria vectors.The studies were conducted five villages located near River Niger, Mali. Baseline village-wide assessments densities for Anopheles gambiae sensu lato performed...
Abstract Background Cipargamin (KAE609) is a potent antimalarial in phase II trial. Here we report efficacy, pharmacokinetics, and resistance marker analysis across range of cipargamin doses. These were secondary endpoints from study primarily conducted to assess the hepatic safety (hepatic data are reported elsewhere). Methods This II, multicenter, randomized, open-label, dose-escalation trial was sub-Saharan Africa adults with uncomplicated Plasmodium falciparum malaria. monotherapy given...
Questions remain concerning the rapidity of immune responses and durability safety vaccines used to prevent Zaire Ebola virus disease.
Objectives This study aims: (1) to identify and describe similarities differences in both adult child COVID-19 vaccine hesitancy, (2) examine sociodemographic, perception-related behavioural factors influencing hesitancy across five West African countries. Design Cross-sectional survey carried out between 5 May June 2021. Participants setting 4198 individuals from urban rural settings Burkina Faso, Guinea, Mali, Senegal Sierra Leone participated the survey. Study registration The general...
Abstract Background Based on recent studies in Israel demonstrating that attractive toxic sugar bait (ATSB) methods can be used to decimate local anopheline and culicine mosquito populations, an important consideration is whether the same adapted improved attract kill malaria vectors Africa. The ATSB approach uses fruit or flower scent as attractant, solution a feeding stimulant, oral toxin. solutions are either sprayed vegetation suspended simple stations, mosquitoes ingesting killed. As...
The World Health Organization (WHO) recently recommended that the time to first malaria episode serve as primary end point in phase III vaccine trials--the of which will be held Africa. Although common red blood cell (RBC) polymorphisms such sickle hemoglobin (HbS) are known protect against Africa, their impact on this has not been investigated.A longitudinal study 225 individuals aged 2-25 years was conducted Mali. association between RBC and evaluated.Among children 2-10 years, trait...
A neglected aspect of alien invasive plant species is their influence on mosquito vector ecology and malaria transmission. Invasive plants that are highly attractive to Anopheles mosquitoes provide them with sugar critical survival. The effect populations was examined through a habitat manipulation experiment removed the flowering branches Prosopis juliflora from selected villages in Mali, West Africa.Nine Bandiagara district Mali were selected, six juliflora, three without. CDC-UV light...
MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for worldwide. The worldwide roll-out of GeneXpert MTB/RIF® has improved diagnosis MDR-TB; however, in many countries laboratories are unable assess drug resistance and clinical predictors could help target suspected patients. this study, we aimed determine the factors associated with Bamako, Mali.We performed cross-sectional study 214 patients presumed admitted University Bamako Teaching Hospital, Point-G between...
Bioinformatics and data science research has boundless potential across Africa due to its high levels of genetic diversity disproportionate burden infectious diseases, including malaria, tuberculosis, HIV/AIDS, Ebola virus disease, Lassa fever. This work lays out an incremental training approach for engaging underserved populations in bioinformatics at the University Sciences, Techniques Technologies Bamako, Mali (USTTB). Two informatics programs sponsored by Fogarty International Center...
Current tools and strategies are not sufficient to reliably address threats outbreaks of arboviruses including Zika, dengue, chikungunya, yellow fever. Hence there is a growing public health challenge identify the best new control use against vector Aedes aegypti. In this study, we investigated Ae. aegypti sugar feeding in Bamako, Mali, determine if species can be controlled effectively using attractive toxic baits (ATSB).
Attractive targeted sugar baits (ATSBs) are a promising new tool for malaria control as they can target outdoor-feeding mosquito populations, in contrast to current vector tools which predominantly indoor-feeding mosquitoes.It was sought estimate the potential impact of these on Plasmodium falciparum prevalence African settings by combining data from recent entomological field trial ATSBs undertaken Mali with mathematical models transmission. The key parameter determining population is...
In Mali, a country in West Africa, cumulative confirmed COVID-19 cases and deaths among healthcare workers (HCWs) remain enigmatically low, despite series of waves, circulation SARS-CoV-2 variants, the country's weak system, general lack adherence to public health mitigation measures. The goal study was determine whether exposure is important by assessing seroprevalence anti-SARS-CoV-2 IgG antibodies HCWs. conducted between November 2020 June 2021. HCWs major hospitals where were being cared...
As malaria prevalence declines in many parts of the world due to widescale control efforts and as drug-resistant parasites begin emerge, a quantitative understanding human movement is becoming increasingly relevant control. However, despite its importance, significant knowledge gaps remain regarding movement, particularly sub-Saharan Africa. A survey patterns was conducted four countries Africa: Mali, Burkina Faso, Zambia, Tanzania, with three five locations chosen each country. Questions...
Application methods of |Attractive Toxic Sugar Baits (ATSB) need to be improved for wide-scale use, and effects on non-target organisms (NTOs) must assessed. The goals this study were determine, at the village level, effect different configurations bait stations (1) achieve < 25% Anopheles mosquito vector daily feeding rate both males females (2) minimize organisms.