Caterina Fanello
A5029054664- Malaria Research and Control
- Mosquito-borne diseases and control
- Drug-Induced Hepatotoxicity and Protection
- Global Maternal and Child Health
- Computational Drug Discovery Methods
- Pharmacological Effects and Toxicity Studies
- Insect Resistance and Genetics
- HIV/AIDS drug development and treatment
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Viral Infections and Outbreaks Research
- Insect Pest Control Strategies
- Multiple Myeloma Research and Treatments
- Parasites and Host Interactions
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Trypanosoma species research and implications
- Drug Transport and Resistance Mechanisms
- Child Nutrition and Water Access
- Vector-borne infectious diseases
- Pharmacogenetics and Drug Metabolism
- Moringa oleifera research and applications
- Viral Infections and Vectors
- Vibrio bacteria research studies
- Liver Disease and Transplantation
Mahidol Oxford Tropical Medicine Research Unit
2014-2025
Mahidol University
2014-2025
University of Oxford
2015-2025
University of Kinshasa
2017-2023
Monash University
2023
Ministry of Public Health
2022
Nuffield Orthopaedic Centre
2008-2015
Hospital for Tropical Diseases
2014
London School of Hygiene & Tropical Medicine
1999-2013
Churchill Hospital
2012
Artemisinin resistance in Plasmodium falciparum has emerged Southeast Asia and now poses a threat to the control elimination of malaria. Mapping geographic extent is essential for planning containment strategies.Between May 2011 April 2013, we enrolled 1241 adults children with acute, uncomplicated malaria an open-label trial at 15 sites 10 countries (7 3 Africa). Patients received artesunate, administered orally daily dose either 2 mg per kilogram body weight day or 4 kilogram, days,...
Abstract For differential identification of sibling species in the Anopheles gambiae Giles complex (Diptera: Culicidae), including simultaneous separation M and S molecular forms within An. sensu stricto , we describe a PCR‐RFLP method. This procedure is more efficient, faster cheaper than those used before, so recommended for large‐scale processing field‐collected larval adult specimens to be identified malaria vector studies.
Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment delay emergence of antimalarial resistance.
MalariaGEN is a data-sharing network that enables groups around the world to work together on genomic epidemiology of malaria. Here we describe new release curated genome variation data 7,000 Plasmodium falciparum samples from partner studies in 28 malaria-endemic countries. High-quality genotype calls 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using standardised analysis pipeline. Copy number variants associated with drug resistance structural cause...
<ns3:p>We describe the MalariaGEN Pf7 data resource, seventh release of <ns3:italic>Plasmodium falciparum</ns3:italic> genome variation from network. It comprises over 20,000 samples 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For first time we include dried blood spot sequenced after selective whole amplification, necessitating new methods to genotype copy number variations. We identify a large newly emerging...
Abstract We karyotyped and identified by polymerase chain reaction restriction fragment length polymorphism (PCR‐RFLP) analysis Anopheles gambiae s.s. samples collected in several African countries. The data show the existence of two non‐panmictic molecular forms, named S M, whose distribution extended from forest to savannahs. Mosquitoes M forms are homosequential standard for chromosome‐2 inversions areas. In dry savannahs, is characterized mainly inversion polymorphisms typical Savanna...
Background. Data from the largest randomized, controlled trial for treatment of children hospitalized with severe malaria were used to identify such predictors a poor outcome malaria. Methods. African (<15 years) participated in randomized comparison parenteral artesunate and quinine 9 countries. Detailed clinical assessment was performed on admission. Parasite densities assessed reference laboratory. Predictors death examined using multivariate logistic regression model. Results. Twenty...
In African children, distinguishing severe falciparum malaria from other febrile illnesses with coincidental Plasmodium parasitaemia is a major challenge. P. histidine-rich protein 2 (PfHRP2) released by mature sequestered parasites and can be used to estimate the total parasite burden. We investigated prognostic significance of plasma PfHRP2 it malaria-attributable fraction in children diagnosed malaria.Admission was measured prospectively (from Mozambique, The Gambia, Kenya, Tanzania,...
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for surveillance malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale projects by integrating simple sample collection procedures routine public health procedures. Methods: Samples from symptomatic patients are processed SpotMalaria, high-throughput system produces comprehensive set genotypes comprising...
Abstract In Mali the Anopheles gambiae complex consists of An. arabiensis and Mopti, Savanna Bamako chromosomal forms s.s. Previous data suggests a complete reproductive isolation among these forms. Sequence analysis rDNA regions led to characterization two molecular , named M‐form S‐form, which in correspond Mopti Savanna/Bamako, respectively, while it has failed so far show any difference between Bamako. The population structure s.l. was analysed three villages Sikasso areas frequency...
Journal Article Safety and efficacy of dihydroartemisinin/piperaquine (Artekin®) for the treatment uncomplicated Plasmodium falciparum malaria in Rwandan children Get access Corine Karema, Karema aNational Malaria Control Program, Kigali, Rwanda Search other works by this author on: Oxford Academic PubMed Google Scholar Caterina I. Fanello, Fanello ⁎ bLondon School Hygiene Tropical Medicine, Keppel Street, London WC1E 7HT, UK ⁎Corresponding author. E-mail address:...
<ns3:p>MalariaGEN is a data-sharing network that enables groups around the world to work together on genomic epidemiology of malaria. Here we describe new release curated genome variation data 7,000 <ns3:italic>Plasmodium falciparum</ns3:italic> samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using standardised analysis pipeline. Copy number variants associated...
Abstract Experimental huts in Côte d’Ivoire were used to evaluate the pyrethroid alpha-cypermethrin, non-ester etofenprox, organophosphate pirimiphos-methyl and carbamate carbosulfan on bednets against pyrethroid-resistant Anopheles gambiae Giles. To test for selection resistance gene by treated nets, A. collected live or dead from kept analysed presence of kdr using a new polymerase chain reaction followed sequence-specific oligonucleotide probing (PCR–SSOP) -genotyping. Deliberately holed...
Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing larger segments between artemisinin-resistant parasites versus sensitive parasites,...
Paracheck-Pf is a rapid, qualitative immuno-assay for the detection of Plasmodium falciparum-specific histidine-rich protein-2 in samples human blood. The assay has now been evaluated, against usual 'gold standard', microscopy, using blood from 1655 individuals five districts Tanzania, four which experience frequent malaria outbreaks. aim was to verify whether could be reliable tool confirmation outbreaks such areas. overall measurements assay's performance were good, with sensitivity 90.0%,...
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited human enzyme defect. This provides some protection from clinical malaria, but it can also cause haemolysis after administration of drugs with oxidant properties. Methods The safety chlorproguanil-dapsone+artesunate (CD+A) and amodiaquine+sulphadoxine-pyrimethamine (AQ+SP) for treatment uncomplicated P. falciparum malaria was evaluated according to G6PD in a secondary analysis an open-label, randomized...
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Coartem is a fixed-dose combination of artemether-lumefantrine that, given in six doses, provides effective treatment for children with uncomplicated Plasmodium falciparum infection areas highly endemic and multidrug-resistant malaria. In Rwanda since 2001, amodiaquine+sulfadoxine-pyrimethamine (AQ+SP) has been the first-line treatment, but resistance to this rapidly emerged spread. was considered as possible alternative, randomised, open-label, clinical trial test its safety, tolerability...
Antifolate drugs have an important role in the treatment of malaria. Polymorphisms genes encoding dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to antifol sulfa drugs, respectively. Rwanda has highest levels antimalarial drug Africa. We correlated efficacy chlorproguanil-dapsone plus artesunate (CPG-DDS+A) amodiaquine sulfadoxine-pyrimethamine (AQ+SP) children with uncomplicated malaria caused by Plasmodium falciparum parasites pfdhfr pfdhps mutations, which...