A5016424321- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Global Maternal and Child Health
- Insect Pest Control Strategies
- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- Reproductive tract infections research
- Viral Infections and Vectors
- Cervical Cancer and HPV Research
- Syphilis Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Reproductive System and Pregnancy
- Vector-borne infectious diseases
- International Human Rights and Reproductive Law
- Livestock and Poultry Management
- Dermatological diseases and infestations
- Global Health and Epidemiology
- Computational Drug Discovery Methods
- HIV/AIDS Impact and Responses
- Milk Quality and Mastitis in Dairy Cows
- Drug Transport and Resistance Mechanisms
- Vibrio bacteria research studies
- Plant Ecology and Soil Science
World Health Organization
2019-2024
Global Fund to Fight AIDS, Tuberculosis and Malaria
2013-2016
Impact
2015
University of London
1998-2013
London School of Hygiene & Tropical Medicine
2003-2012
Malaria Consortium
2006-2012
Kenya Medical Research Institute
2012
Malaria Consortium
2007-2012
University of Leeds
2005
National University of East Timor
2003
Anopheles stephensi mosquitoes, efficient vectors in parts of Asia and Africa, were found 75.3% water sources surveyed contributed to 80.9% wild-caught mosquitoes Awash Sebat Kilo, Ethiopia. High susceptibility these Plasmodium falciparum vivax infection presents a challenge for malaria control the Horn Africa.
Insecticide-treated nets (ITNs) for malaria control are widespread but coverage remains inadequate. We developed a Bayesian model using data from 102 national surveys, triangulated against delivery and distribution reports, to generate year-by-year estimates of four ITN indicators. explored the impact two potential 'inefficiencies': uneven net among households rapid rates loss households. estimated that, in 2013, 21% (17%-26%) ITNs were over-allocated this has worsened over time as overall...
Pentavalent antimony is the agent recommended for treatment of cutaneous leishmaniasis (CL). Its use problematic, because it expensive and potential drug-associated adverse effects during a lengthy painful course.We tested efficacy thermotherapy CL due to Leishmania tropica in randomized, controlled trial Kabul, Afghanistan. We enrolled 401 patients with single lesion administered using radio-frequency waves (1 >or=1 consecutive application at 50 degrees C 30 s) or sodium stibogluconate...
Background In East Africa, visceral leishmaniasis (VL) is endemic in parts of Sudan, Ethiopia, Somalia, Kenya and Uganda. It caused by Leishmania donovani transmitted the sandfly vector Phlebotomus martini. Pokot focus, reaching from western into eastern Uganda, formulation a prevention strategy has been hindered lack knowledge on VL risk factors as well support health sector donors. The present study was conducted to establish necessary evidence-base stimulate interest supporting control...
Combining the delivery of multiple health interventions has potential to minimize costs and expand intervention coverage. Integration mass drug administration is therefore being encouraged for preventive chemotherapy (PCT) control onchocerciasis, lymphatic filariasis, schistosomiasis, soil-transmitted helminthiasis, trachoma in sub-Saharan Africa, as there considerable geographical overlap these neglected tropical diseases (NTDs). With only a handful countries having embarked on integrated...
Abstract Experimental huts in Côte d’Ivoire were used to evaluate the pyrethroid alpha-cypermethrin, non-ester etofenprox, organophosphate pirimiphos-methyl and carbamate carbosulfan on bednets against pyrethroid-resistant Anopheles gambiae Giles. To test for selection resistance gene by treated nets, A. collected live or dead from kept analysed presence of kdr using a new polymerase chain reaction followed sequence-specific oligonucleotide probing (PCR–SSOP) -genotyping. Deliberately holed...
Vivax malaria remains a major cause of morbidity in the subtropics. To undermine stability disease, drugs are required that prevent relapse and provide reservoir reduction. A 14-day course primaquine (PQ) is effective but cannot safely be used routine practice because its interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency for which testing seldom available. Safe use PQ without need G6PD would ideal. The efficacy safety an 8-week, once weekly regimen was compared current...
In Ethiopia, malaria transmission is seasonal and unstable, with both Plasmodium falciparum vivax endemic. Such spatial temporal clustering of only serves to underscore the importance regularly collecting up-to-date surveillance data inform decision-making in control. Cross-sectional school-based surveys were conducted across Oromia Regional State generate for planning control interventions, as well monitoring evaluation operational programme implementation. Two hundred primary schools...
Plasmodium-helminth coinfection can have a number of consequences for infected hosts, yet our knowledge the epidemiology across multiple settings is limited. This study investigates distribution and heterogeneity with Plasmodium falciparum 3 major helminth species East Africa.Cross-sectional parasite surveys were conducted among 28 050 children in 299 schools range environmental Kenya, Uganda, Ethiopia. Data on individual, household, risk factors collected spatially explicit Bayesian...
During November and December 1998, 16 Afghan refugee camps were surveyed for anthroponotic cutaneous leishmaniasis (ACL). Prevalence of active lesions scars amongst the population was 2.7% 2.4%, respectively. Between prevalence varied from 0.3 to 8.8% that 5.8%. Random-effects logistic regression indicated risk ACL associated with age but not gender. This model also a significant clustering at household level. The average annual force infection estimated be 0.046 per year (4.6 cases/1000...
Abstract The epidemiology of anthroponotic cutaneous leishmaniasis was investigated in northwest Pakistan. Results suggested similar patterns endemicity both Afghan refugee and Pakistani populations highlighted risk factors household clustering disease.
Background Trachoma is a major cause of blindness in Southern Sudan. Its distribution has only been partially established and many communities need intervention have therefore not identified or targeted. The present study aimed to develop tool improve targeting survey control activities. Methods/Principal Findings A national trachoma risk map was developed using Bayesian geostatistics models, incorporating prevalence data from 112 geo-referenced surveyed between 2001 2009. Logistic...
Summary Objective To evaluate the diagnostic accuracy of a circulating cathodic antigen (CCA) urine dipstick test for detecting Schistosoma mansoni and S. haematobium alongside an integrated rapid mapping survey in Southern Sudan. Methods Results A total 373 children aged 5–16 years were included study. Of these 26.0% infected with 24.5% , as identified by filtration or single Kato–Katz thick smear, respectively. The CCA performed moderately sensitivity 89.1% specificity 74.2%, poorly...
Malaria transmission in Ethiopia is unstable and variable, caused by both Plasmodium falciparum vivax. The Federal Ministry of Health (FMoH) scaling up parasitological diagnosis malaria at all levels the health system; peripheral facilities this will be through use rapid diagnostic tests (RDTs). present study compared three RDT products to provide FMoH with evidence guide appropriate product selection.Performance multi-species (pf-HRP2/pan-pLDH pf-HRP2/aldolase) RDTs (CareStart, ParaScreen...
The only available treatment that can eliminate the latent hypnozoite reservoir of vivax malaria is a 14 d course primaquine (PQ). A potential problem with long-course chemotherapy issue compliance after clinical symptoms have subsided. present study, carried out at an Afghan refugee camp in Pakistan, between June 2000 and August 2001, compared supervised unsupervised groups which was monitored by comparison relapse rates. Clinical cases recruited passive case detection were randomised...