Abdoulaye Djimdé
A5024467013- Malaria Research and Control
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Hemoglobinopathies and Related Disorders
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Invertebrate Immune Response Mechanisms
- Global Maternal and Child Health
- Drug Transport and Resistance Mechanisms
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Travel-related health issues
- Viral Infections and Vectors
- Child Nutrition and Water Access
- Genetics, Bioinformatics, and Biomedical Research
- Complement system in diseases
- Vector-borne infectious diseases
- Aquaculture disease management and microbiota
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
University of Bamako
2016-2025
Université des Sciences, des Techniques et des Technologies de Bamako
2016-2025
Université de Perpignan
2024-2025
Mali-Folkecenter
2025
National Institute of Allergy and Infectious Diseases
2000-2024
National Institutes of Health
2000-2024
Frederick National Laboratory for Cancer Research
2024
Institut National de Recherche en Santé Publique
2024
Institut Pasteur de Madagascar
2024
Centre for Human Genetics
2003-2023
Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa. Chloroquine resistance has been associated vitro with point mutations two genes, pfcrt and pfmdr 1, which encode the P. digestive-vacuole transmembrane proteins PfCRT Pgh1, respectively.To assess value of these as markers for clinical chloroquine resistance, we measured association between response to treatment patients uncomplicated Mali. The frequencies before after were...
"Pyrimethamine and Proguanil Resistance-Conferring Mutations in Plasmodium falciparum Dihydrofolate Reductase: Polymerase Chain Reaction Methods for Surveillance Africa" published on Jun 1995 by The American Society of Tropical Medicine Hygiene.
In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response high rates of chloroquine-resistant falciparum malaria. To determine whether withdrawal can lead reemergence sensitivity, prevalence pfcrt 76T molecular marker for Plasmodium malaria was retrospectively measured Blantyre, Malawi. The genotype decreased from 85% 1992 13% 2000. 2001, cleared 100% 63 asymptomatic P. infections, no isolates were resistant vitro, and...
To assess the relationship between mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) clinical pyrimethamine-sulfadoxine resistance, polymerase chain reaction surveys analyses for new were conducted four countries with increasing levels of resistance: Mali, Kenya, Malawi, Bolivia. Prevalence at DHFR codon 108 a mutation DHPS 540 correlated increased resistance (P < .05). Mutations 51, 59, 437 without achieving statistical significance. 164...
Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance Southeast Asia. This study investigated prevalence polymorphisms across sub-Saharan Africa. A total 1212 P. samples collected from 12 countries were sequenced. None mutations previously reported Asia found, but 22 unique detected, which 7 nonsynonymous. Allele frequencies ranged between 1% and 3%. Three observed >1 country, A578S was present parasites 5...
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the component partner drug. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter ( pfcrt ) P. multidrug 1 pfmdr1 genes are associated with decreased sensitivity to amodiaquine lumefantrine, but effects of these polymorphisms therapeutic responses artesunate-amodiaquine (ASAQ) artemether-lumefantrine (AL) have not been clearly defined. Individual patient data from 31 trials were...
BackgroundSeasonal malaria chemoprevention (SMC) aims to prevent in children during the high transmission season. The Achieving Catalytic Expansion of SMC Sahel (ACCESS-SMC) project sought remove barriers scale-up seven countries 2015 and 2016. We evaluated project, including coverage, effectiveness intervention, safety, feasibility, drug resistance, cost-effectiveness.MethodsFor this observational study, we collected data on delivery, effectiveness, influence costs impact incidence...
Elucidation of the evolutionary history and interrelatedness Plasmodium species that infect humans has been hampered by a lack genetic information for three human-infective species: P. malariae two ovale (P. o. curtisi wallikeri). These are prevalent across most regions in which malaria is endemic often undetectable light microscopy, rendering their study human populations difficult. The exact relationship these to other contested. Using new reference genome manually curated draft genome, we...
Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions Africa.We conducted an individually randomized, controlled trial to assess whether seasonal vaccination with RTS,S/AS01E was noninferior chemoprevention preventing uncomplicated malaria two interventions combined were superior either one alone severe malaria-related outcomes.We randomly assigned 6861 children 5 17 months age receive sulfadoxine-pyrimethamine amodiaquine (2287 [chemoprevention-alone group]),...
MalariaGEN is a data-sharing network that enables groups around the world to work together on genomic epidemiology of malaria. Here we describe new release curated genome variation data 7,000 Plasmodium falciparum samples from partner studies in 28 malaria-endemic countries. High-quality genotype calls 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using standardised analysis pipeline. Copy number variants associated with drug resistance structural cause...
<ns3:p>We describe the MalariaGEN Pf7 data resource, seventh release of <ns3:italic>Plasmodium falciparum</ns3:italic> genome variation from network. It comprises over 20,000 samples 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For first time we include dried blood spot sequenced after selective whole amplification, necessitating new methods to genotype copy number variations. We identify a large newly emerging...
CIS43LS is a monoclonal antibody that was shown to protect against controlled Plasmodium falciparum infection in phase 1 clinical trial. Whether can prevent P. region which the endemic unknown.We conducted 2 trial assess safety and efficacy of single intravenous infusion healthy adults Mali over 6-month malaria season. In Part A, assessed at three escalating dose levels. B, participants were randomly assigned (in 1:1:1 ratio) receive 10 mg per kilogram body weight, 40 kilogram, or placebo....
BackgroundSubcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether administered subcutaneously can protect children from P. region where this organism is endemic unclear.MethodsWe conducted 2 trial Mali to assess safety and efficacy subcutaneous 6 10 years age over 6-month malaria season. In part A trial, was assessed at three dose levels adults, followed by assessment two children. B were...
Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended to prevent parasite from invading and replicating within host cells. No blood-stage vaccine has shown clinical efficacy in humans. Most antigens surface proteins that have evolved extensive genetic diversity, this diversity could allow parasites escape vaccine-induced immunity. We examined extent within-host dynamics antigen apical membrane antigen-1 a longitudinal study Mali. Two hundred fourteen unique...
Our understanding of the composition multi-clonal malarial infections and epidemiological factors which shape their diversity remain poorly understood. Traditionally within-host has been defined in terms multiplicity infection (MOI) derived by PCR-based genotyping. Massively parallel, single molecule sequencing technologies now enable individual read counts to be on genome-wide datasets facilitating development new statistical approaches describe diversity. In this class measures FWS metric...
A randomized trial reported by Alassane Dicko and colleagues shows that intermittent preventive treatment for malaria in children who are protected from mosquitoes insecticide-treated bednets provides substantial protection malaria.
Ebb and flow of parasite populations The population genetics the malaria Plasmodium falciparum across Africa is poorly understood but important to know for grasping risks dynamics spread drug resistance. Harnessing power genomics, Amambua-Ngwa et al. Diversity Network found substantial structure within that consistent with human vector divergence (see Perspective by Sibley). Specific signatures selection antimalarial drugs were detected, along indications effect colonization slavery....
Abstract Malaria is a major public health problem that actively being addressed in global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant new regions. A simple genetic marker quickly accurately identifies geographic origin infections would be valuable tool for locating source imported outbreaks. Here we analyse mitochondrion apicoplast genomes 711...