Corinne Merle
A5076621207- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Malaria Research and Control
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Global Maternal and Child Health
- Respiratory viral infections research
- Infectious Diseases and Tuberculosis
- Pharmacovigilance and Adverse Drug Reactions
- Health Systems, Economic Evaluations, Quality of Life
- HIV-related health complications and treatments
- Viral Infections and Vectors
- Hepatitis C virus research
- Pharmaceutical studies and practices
- Inhalation and Respiratory Drug Delivery
- Sex work and related issues
- COVID-19 epidemiological studies
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- Influenza Virus Research Studies
World Health Organization
2016-2025
World Health Organization - Pakistan
2024-2025
Special Programme for Research and Training in Tropical Diseases
2015-2024
Cheikh Anta Diop University
2024
Hospital for Tropical Diseases
2021-2024
Progamme National Contre le Tuberculose
2024
London School of Hygiene & Tropical Medicine
2008-2022
Centre Hospitalier Universitaire de Montpellier
2002-2022
Bayero University Kano
2022
Kaduna State University
2022
Shortening the course of treatment for tuberculosis would be a major improvement case management and disease control. This phase 3 trial assessed efficacy safety 4-month gatifloxacin-containing regimen treating rifampin-sensitive pulmonary tuberculosis.We conducted noninferiority, randomized, open-label, controlled involving patients 18 to 65 years age with smear-positive, rifampin-sensitive, newly diagnosed in five sub-Saharan African countries. A standard 6-month that included ethambutol...
BackgroundSeasonal malaria chemoprevention (SMC) aims to prevent in children during the high transmission season. The Achieving Catalytic Expansion of SMC Sahel (ACCESS-SMC) project sought remove barriers scale-up seven countries 2015 and 2016. We evaluated project, including coverage, effectiveness intervention, safety, feasibility, drug resistance, cost-effectiveness.MethodsFor this observational study, we collected data on delivery, effectiveness, influence costs impact incidence...
Abstract There is urgent need for new drug regimens that more rapidly cure tuberculosis (TB). Existing TB drugs and vary in treatment-shortening activity, but the molecular basis of these differences unclear, no existing assay directly quantifies ability a or regimen to shorten treatment. Here, we show historically classified as sterilizing non-sterilizing have distinct impacts on fundamental aspect Mycobacterium physiology: ribosomal RNA (rRNA) synthesis. In culture, mice, human studies,...
BackgroundAround 500 000 people worldwide develop rifampicin-resistant tuberculosis each year. The proportion of successful treatment outcomes remains low and new treatments are needed. Following an interim analysis, we report the final safety efficacy TB-PRACTECAL trial, evaluating oral regimens for tuberculosis.MethodsThis open-label, randomised, controlled, multi-arm, multicentre, non-inferiority trial was conducted at seven hospital community sites in Uzbekistan, Belarus, South Africa,...
Abstract Background Only 63% of patients initiating multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment in 2020 were treated successfully. 24-Week all-oral bedaquiline, pretomanid, and linezolid (BPaL)–based regimens have demonstrated higher rates success been recommended by the World Health Organization. Operational research is urgently required to evaluate these non-trial settings. Methods This was a prospective cohort study with microbiologically confirmed...
Spinal cord injury (SCI) patients with neurogenic bladder have an increased risk for symptomatic urinary tract infection (UTI). Recurrent UTI requires multiple courses of antibiotic therapy, markedly increasing the incidence multidrug-resistant (MDR) bacteria.During observational prospective study, we determined safety and efficacy a weekly oral cyclic (WOCA) regimen to prevent in SCI adult undergoing clean intermittent catheterization. The WOCA consisted alternate administration once per...
The currently recommended doses of rifampin are believed to be at the lower end dose-response curve. Rifampin induces its own metabolism, although effect dose on extent autoinduction is not known. This study aimed investigate using a semimechanistic pharmacokinetic-enzyme turnover model. Four different structural basic models were explored assess whether scaling methods affected final covariate selection procedure. Covariates selected by linearized approach. model included allometric oral...
BackgroundThe Xpert MTB/RIF (Xpert) assay is used globally to rapidly diagnose tuberculosis and resistance rifampicin. We investigated the frequency predictors of false-positive findings rifampicin with Xpert.MethodsWe did a prospective, observational study individuals who were enrolled in Rwandan nationwide diagnostic cohort (DIAMA trial; NCT03303963). included patients identified have on initial testing. repeat rpoB Sanger deep sequencing alongside phenotypic drug susceptibility testing...
Abstract Background Globally rifampicin-resistant tuberculosis disease affects around 460,000 people each year. Currently recommended regimens are 9–24 months duration, have poor efficacy and carry significant toxicity. A shorter, less toxic more efficacious regimen would improve outcomes for with tuberculosis. Methods TB-PRACTECAL is an open-label, randomised, controlled, phase II/III non-inferiority trial evaluating the safety of 24-week containing bedaquiline pretomanid to treat Conducted...
SMC was adopted in Nigeria 2014 and by 2021 being implemented 18 states, over four months between June October 143000 community drug distributors (CDDs) to a target population of 23million children. Further expansion is planned, extending 21 states with or five monthly cycles. In view this massive scale-up, the National Malaria Elimination Programme undertook qualitative research shortly after campaign understand attitudes so that these perspectives inform future planning delivery Nigeria.
Sources and Assessment of Occupational Stress in the Police: Frédéric Deschamps, et al. Department Health, Faculté de Médecine, Reims, France —The role police Western society is undergoing a transformation that reflects economic social technological changes community assertion individual rights within democracy. The aim this study to evaluate level stress among group French policemen examine association between policing, potential stressors levels. sample drawn from large metropolitan force...
Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizing enzymes. This study evaluated whether the polymorphisms these enzymes were an increased risk of anti-TB drug-induced hepatitis patients and could potentially be used identify liver injury.In a cross-sectional study, 2244...
Despite marked progress in Senegal, three regions the southeast part continue to have a high burden of malaria, but there been no recent studies assessing prevalence malaria associated with pregnancy. This study aimed determine infection pregnant women attending antenatal clinics Senegal. During transmission season 2019, 11 health care facilities for scheduled visit and those presenting unwell signs were invited participate screening study. A finger prick blood sample was taken diagnosis by...
Persistent immune activation in virologically suppressed HIV-1 patients, which may be the consequence of various factors including microbial translocation, is a major cause comorbidities. We have previously shown that different profiles distinguished virological responders. Here, we tested hypothesis particular profile might translocation. To this aim, measured 64 soluble and cell surface markers inflammation CD4+ CD8+ T-cell, B cell, monocyte, NK endothelial 140 adults under efficient...
Abstract A workshop on implementation strategies for the introduction of RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas highly seasonal transmission, was held as a hybrid meeting Dakar, Senegal, and online, 23–25 January 2023. Delegates from Expanded Programmes Immunization (EPI) National Malaria Control (NMCPs) 13 African countries, representatives key stakeholders participated. RTS,S is first to be recommended by World Health Organization (WHO). The recommendation followed...
BackgroundProgress in tuberculosis control China has been the slowest western areas, which have highest prevalence. We assessed prevalence of pulmonary Xinjiang province, China, 10 years after introduction a programme based on directly observed treatment, short course.MethodsIn this population-based, cross-sectional survey, we used multistage stratified random cluster sample design to estimate smear-positive and bacteriologically confirmed (either smear positive or culture positive, both)...