A5085919387- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Global Maternal and Child Health
- Fungal Infections and Studies
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Water Access
- Parasitic Infections and Diagnostics
- Nail Diseases and Treatments
- Antifungal resistance and susceptibility
- Computational Drug Discovery Methods
- Plant Pathogens and Fungal Diseases
- Amoebic Infections and Treatments
- Multiple Myeloma Research and Treatments
- HIV/AIDS drug development and treatment
- Iron Metabolism and Disorders
- Reproductive tract infections research
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Parasite Biology and Host Interactions
- Viral Infections and Outbreaks Research
- Bacterial Identification and Susceptibility Testing
- Tuberculosis Research and Epidemiology
- Actinomycetales infections and treatment
- Infectious Diseases and Mycology
Cheikh Anta Diop University
2015-2024
Centre Hospitalier National Universitaire de Fann
2012-2022
Gendarmerie Nationale
2016
Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), given each month during the transmission season, is recommended for children living in areas of Sahel where malaria highly seasonal. The recommendation SMC currently limited to under five years age, but, many seasonal transmission, burden older may justify extending this age limit. This study was done determine effectiveness Senegalese up ten age.SMC introduced into three districts over central...
BackgroundPeer-reviewed literature on health is almost exclusively published in English, limiting the uptake of research for decision making francophone African countries. We used results from Global Burden Diseases, Injuries, and Risk Factors Study (GBD) 2017 to assess burden disease Africa inform professionals their partners region.MethodsWe assessed 21 countries compared with those non-francophone counterparts three economic communities: Economic Community West States, Central Southern...
Seasonal malaria chemoprevention (SMC) is recommended in the Sahel region of Africa for children under 5 years age, up to 4 months year. It may be appropriate include older children, and provide protection more than months. We evaluated effectiveness SMC using sulfadoxine-pyrimethamine plus amodiaquine given over 10 age Saraya district south-east Senegal 2011.
In Senegal, the widespread use of vector control measures has resulted in a significant reduction malaria burden and led country to consider possibility elimination. Given this shift changing context, it is important characterize across all age groups guide decision-making on programmatic interventions interrupt transmission ultimately eradicate disease. there lack information prevalence among certain populations, particularly adolescents adults. This study sought assess magnitude infections...
The use of artemisinin-based combination therapy (ACT) is currently recommended for treating uncomplicated malaria. objective was to assess the efficacy and safety repeated administrations two fixed-dose presentations ACT - artesunate plus amodiaquine (ASAQ) artemether-lumefantrine (AL) in subsequent episodes Plasmodium falciparum A randomized comparative study conducted a rural community central Senegal from August 2007 January 2009. Children adults with P. malaria were receive open-label...
The choice of appropriate artemisinin-based combination therapy depends on several factors (cost, efficacy, safety, reinfection rate and simplicity administration). To assess whether the dihydroartemisinin-piperaquine (DP) could be an alternative to artemether-lumefantrine (AL), efficacy tolerability two products for treatment uncomplicated falciparum malaria in sub-Saharan Africa have been compared. A multicentric open randomized controlled clinical trial three-day DP against AL parallel...
While malaria morbidity has sharply declined in several areas Senegal, it remains an important problem the southern part of country, particularly among adolescents. Understanding adolescents' knowledge, attitudes, prevention and care-seeking practices is to inform more targeted interventions aimed at optimizing uptake control measures. This study assessed malaria-related (KAP) adolescents living a highly persistent transmission area Senegal.
Despite marked progress in Senegal, three regions the southeast part continue to have a high burden of malaria, but there been no recent studies assessing prevalence malaria associated with pregnancy. This study aimed determine infection pregnant women attending antenatal clinics Senegal. During transmission season 2019, 11 health care facilities for scheduled visit and those presenting unwell signs were invited participate screening study. A finger prick blood sample was taken diagnosis by...
As a result of widespread antimalarial drug resistance, all African countries with endemic malaria have, in recent years, changed their treatment policy. In Senegal, the health authorities from chloroquine (CQ) to combination sulfadoxine–pyrimethamine (SP) plus amodiaquine (AQ) 2003. Since 2006, artemisinin therapies (ACTs) artemether–lumefantrine (AL) and artesunate (AS/AQ) were adopted for uncomplicated treatment. After several years CQ withdrawal, current study wished determine level...
Objective To compare, in a phase IV trial, the efficacy and tolerability of artesunate-amodiaquine (Camoquin plus®) dosed at 300 600 mg amodiaquine per tablet to artemether-lumefantrine (Coartem®) for treatment Plasmodium falciparum uncomplicated malaria Ivory Cost Senegal. Method Multisite, randomised, open-labelled study patients over age 7 years. The primary endpoint was adequate clinical parasitological response (ACPR) day 28. secondary endpoints were fever parasite clearance gametocyte...
Malaria and anaemia (Haemoglobin <11 g/dl) remain frequent in tropical regions are closely associated. Although aetiologies known to be multi-factorial, most studies malaria endemic areas have been confined analysis of possible associations between individual factors such as malaria. A case control study involving children aged from 1 10 years was conducted assess some assumed contributors the area Bonconto Health post Senegal. Study participants were randomly selected a list who...
As the global burden of malaria decreases, routine health information systems (RHIS) have become invaluable for monitoring progress towards elimination. The District Health Information System, version 2 (DHIS2) has been widely adopted across countries and is expected to increase quality reporting RHIS. In this study, we evaluated key indicators childhood from January 2014 through December 2017, first 4 years DHIS2 implementation in Senegal.Monthly data on number confirmed suspected cases as...
An open randomized clinical trial study was carried out to compare efficacy and tolerability of artesunate mefloquine 25 mg/kg body weight (Artequin paediatric) versus artemether lumefantrine (Coartem) in the treatment uncomplicated Plasmodium falciparum malaria children. In each arm, 160 patients were assigned receive either AS + MQ or AL with 28 days follow-up. The adequate parasitological response at Day for per protocol analysis after polymerase chain reaction correction, 100% 96.8% AL....
Malaria remains a major public health problem in developing countries. Then these countries prompt access to effective antimalarial treatment such as Artemisinin based-Combination Therapies (ACT) proves be an essential tool for controlling the disease. In Senegal, since 2006 nationwide scaling up program of ACT is being implemented. this context it has become relevant monitor efficacy and provide recommendations Senegalese national malaria control program.An open randomized trial was...
Malaria is endemic in Senegal. The national malaria control strategy focuses on achieving universal coverage for major interventions, with a goal of reaching preelimination status by 2018. Senegal began distribution insecticide-treated nets (ITNs) and introduced artemisinin-based combination therapy 2006, then rapid diagnostic tests 2007. We evaluated the impact these efforts using plausibility design based malaria's contribution to all-cause under-five mortality (ACCM) considering other...
More information is needed about the safety of low-dose primaquine in populations where G6PD deficiency common. Adults with Plasmodium falciparum malaria were randomized to receive 1 3 artemisinin combination therapies (ACTs) or without (0.25 mg/kg). Glucose-6-phosphate dehydrogenase (G6PD) status was determined using a rapid test. Patients followed for 28 days record hemoglobin concentration, adverse events, and gametocyte carriage. The primary end point change Hb at day 7. In sum, 274...
Current malaria control strategies recommend (i) early case detection using rapid diagnostic tests (RDT) and treatment with artemisinin combination therapy (ACT), (ii) pre-referral rectal artesunate, (iii) intermittent preventive (iv) impregnated bed nets. However, these individual interventions provide only partial protection in most epidemiological situations. Therefore, there is a need to investigate the potential benefits of integrating several reduce prevalence morbidity. A randomized...
In sub-Saharan Africa, malaria is the leading cause of morbidity and mortality especially in children. Senegal, seasonal chemoprevention (SMC) previously referred to as intermittent preventive treatment children (IPTc) a new strategy for control areas high transmission. An effectiveness study SMC, using sulphadoxine-pyrimethamine (SP) plus amodiaquine (AQ), was conducted central Senegal from 2008 2010 obtain information about safety, feasibility delivery, cost SMC. Here are report effect SMC...
Home-based management of malaria (HMM) may improve access to diagnostic testing and treatment with artemisinin combination therapy (ACT). In the Sahel region, seasonal chemoprevention (SMC) is now recommended for prevention in children. It likely that combinations antimalarial interventions can reduce burden. This study assessed feasibility, effectiveness safety combining SMC HMM delivered by community health workers (CHWs).A cluster-randomised trial was carried out during two transmission...