A5046342603- Malaria Research and Control
- Mosquito-borne diseases and control
- HIV/AIDS Research and Interventions
- Mental Health Treatment and Access
- Family Caregiving in Mental Illness
- Viral Infections and Vectors
- Essential Oils and Antimicrobial Activity
- HIV Research and Treatment
- Computational Drug Discovery Methods
- Parasites and Host Interactions
- Vector-borne infectious diseases
- HIV/AIDS drug development and treatment
- African Botany and Ecology Studies
- French Urban and Social Studies
- Gene Regulatory Network Analysis
- Zoonotic diseases and public health
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Healthcare Systems and Practices
- Health, Medicine and Society
- Lipoproteins and Cardiovascular Health
- Parasite Biology and Host Interactions
- Microbial Metabolic Engineering and Bioproduction
- Aging, Elder Care, and Social Issues
- Natural product bioactivities and synthesis
Cheikh Anta Diop University
2016-2025
Centre Hospitalier National Universitaire de Fann
2008-2025
Hôpital Aristide Le Dantec
2003-2024
Institute of Health Research, Epidemiological Surveillance and Training
2023-2024
Oxford University Press (United Kingdom)
2024
Centre de Recherche Médicale et Sanitaire
2023
GE Global Research (United States)
2022
Genomics (United Kingdom)
2022
Centre de Suivi Ecologique
2021
Ecole Supérieure d’Economie Appliquée
2016
BackgroundHIV-1 infection is associated with increased risk of tuberculosis and a safe effective vaccine would assist control measures. We assessed the safety, immunogenicity, efficacy candidate vaccine, modified vaccinia virus Ankara expressing antigen 85A (MVA85A), in adults infected HIV-1.MethodsWe did randomised, double-blind, placebo-controlled, phase 2 trial MVA85A HIV-1, at two clinical sites, Cape Town, South Africa Dakar, Senegal. Eligible participants were aged 18–50 years, had no...
Abstract Sero-surveillance can monitor and project disease burden risk. However, SARS-CoV-2 antibody test results produce false positive results, limiting their efficacy as a sero-surveillance tool. False are associated with malaria exposure, understanding this association is essential to interpret from malaria-endemic countries. Here, pre-pandemic samples eight endemic non-endemic countries four continents were tested by ELISA measure Spike S1 subunit reactivity. Individuals acute infection...
Group Interpersonal Therapy (IPT), an evidence-based treatment of depression recommended by the WHO mhGAP Intervention Guide, was implemented through a task-shifting approach in Senegal, as for depressed people living with HIV (PLWH). Since description resources used and implementation costs incurred is necessary to inform policymakers better, this study aimed estimate associated its implementation. were analyzed using "ingredients-based costing approach" from provider's perspective. We...
The 2014 West African outbreak of Ebola virus disease highlighted the urgent need to develop an effective vaccine. We undertook 2 phase 1 studies assessing safety and immunogenicity viral vector modified vaccinia Ankara vectored Zaire vaccine (MVA-EBO-Z), manufactured rapidly on a new duck cell line either alone or in heterologous prime-boost regimen with recombinant chimpanzee adenovirus type 3 (ChAd3-EBO-Z) followed by MVA-EBO-Z. Adult volunteers United Kingdom (n = 38) Senegal 40) were...
We here analyze data from the first year of an ongoing nationwide program genetic surveillance Plasmodium falciparum parasites in Senegal. The analysis is based on 1097 samples collected at health facilities during passive malaria case detection 2019; it provides a baseline for analyzing parasite metrics as they vary over time and geographic space. study's goal was to identify that were informative about transmission intensity other aspects dynamics, focusing measures relatedness between...
ABSTRACT Arthritogenic alphaviruses such as chikungunya (CHIKV) and o'nyong‐nyong (ONNV) viruses have shown capacity to cause widespread epidemics, with recurrent sporadic outbreaks occurring throughout sub‐Saharan Africa. We analyzed the seroprevalence for CHIKV ONNV in 470 non‐febrile subjects from three regions Senegal (Sindia, 2018; Thies, Kedougou, 2022/2023) using retrospective samples. assessed presence of anti‐CHIKV IgG neutralizing antibody titers against via enzyme‐linked...
The use of artemisinin derivative-based combination therapy (ACT) such as artesunate plus amodiaquine is currently recommended for the treatment uncomplicated Plasmodium falciparum malaria. Fixed-dose combinations are more adapted to patients than regimens involving multiple tablets and improve compliance. A fixed-dose + (ASAQ) was recently developed. To assess efficacy safety this new define its optimum dosage regimen (once or twice daily) in P. malaria, a multicentre clinical study...
Molecular epidemiology using genomic data can help identify relationships between malaria parasite population structure, transmission intensity, and ultimately generate actionable to assess the effectiveness of control strategies. Genomic data, coupled with geographic information systems further clusters or hotspots transmission, genetic spatial connectivity, movement by human mosquito mobility over time space. In this study, we performed longitudinal surveillance in a cohort 70 participants...
Objective: To assess adverse effects of long-term highly active antiretroviral therapy (HAART), that is, lipodystrophy and metabolic disorders, in a cohort African patients. Methods: One hundred eighty HIV-1-infected patients treated with HAART for 4-9 years Dakar 180 age-matched sex-matched controls were enrolled. Regional subcutaneous fat changes assessed by physicians, fasting blood samples drawn. Centralization body was estimated using skinfold ratio, waist circumference, to hip ratio...
The use of artemisinin-based combination therapy (ACT) is currently recommended for treating uncomplicated malaria. objective was to assess the efficacy and safety repeated administrations two fixed-dose presentations ACT - artesunate plus amodiaquine (ASAQ) artemether-lumefantrine (AL) in subsequent episodes Plasmodium falciparum A randomized comparative study conducted a rural community central Senegal from August 2007 January 2009. Children adults with P. malaria were receive open-label...
Cardiovascular risk factors in people on antiretroviral treatment (ART) are poorly documented resource-constrained settings. A cross-sectional study was conducted 2009 to assess prevalence of diabetes and hypertension a sample 242 HIV-infected patients who had initiated ART between 1998 2002 Dakar, Senegal (ANRS 1215 observational cohort). World Health Organization (WHO) criteria were applied diagnose hypertension. Multiple logistic regressions used identify associated with Patients median...
Abstract Depression is highly prevalent in people living with HIV (PLWH) and has negative consequences for daily life care. We evaluated the first time acceptability, feasibility benefits of group interpersonal therapy (IPT), combined a task-shifting approach, to treat depression PLWH Senegal. received IPT following World Health Organization protocol. Acceptability criteria were defined from literature data. The PHQ-9, WHODAS, 12-item-stigma scale used, pre- post-treatment, including 3-month...
Abstract The worldwide decline in malaria incidence is revealing the extensive burden of non-malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To characterize NMFI Senegal, we collected venous blood clinical metadata a cross-sectional study patients healthy controls low area. Using 16S untargeted sequencing, detected viral, bacterial, or eukaryotic pathogens 23% (38/163) cases. Bacteria were most common, with relapsing fever Borrelia spotted...
Abstract Background Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance. Methods Data from two decades (2000–2020) of continuous molecular P. parasites Senegal were retrospectively examined assess historical changes mutations. Several known markers their surrounding haplotypes profiled using combination single nucleotide polymorphism (SNP) whole...
The use of artemisinin as a monotherapy resulted in the emergence resistance 2005 Southeast Asia. Monitoring combination therapy (ACT) is critical order to detect and prevent spread endemic areas. Ex vivo studies genotyping molecular markers can be used part this routine monitoring strategy. One gene that has been associated some ACT partner drug Plasmodium falciparum multidrug protein 1 (pfmdr1) gene. purpose study was assess susceptibility P. populations from Thiès, Senegal by ex assay...
Abstract Dengue virus is a major and rapidly growing public health concern in tropic subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue outbreak to date, covering several regions. However, little known about genetic diversity of (DENV) Senegal. Here we report complete viral genomes from 17 previously undetected DENV cases city Thiès. total identified 19 cohort 198 individuals with fever collected October November 2018. We detected 3 co-circulating...
Ventricular fibrillation (VF) is a complete desynchronization of ventricular fibers due to multiple reentry wavelets. The aim our study was determine the frequency as well risk factors for occurrence VF after aortic decompression intraoperatively in cardiac surgery. This prospective observational study, conducted over period 06 months at CHU de Fann center. All patients scheduled surgery under extracorporeal circulation were included. Exclusion criteria with incomplete preoperative and/or...
ABSTRACT West Africa serves as a critical region for the co‐circulation of mosquito‐borne flaviviruses, which often precipitate sporadic outbreaks. This study investigated seropositivity to dengue virus serotypes 1–4 (DENV‐1–4), Zika (ZIKV), yellow fever (YFV), and Nile (WNV) in three regions Senegal: Sindia, Thies, Kedougou. We retrospectively analyzed 470 serum samples flavivirus immunoglobulin G (IgG) using DENV‐2 envelope (E) ELISA. Our findings revealed an overall seroprevalence 37.23%....
Background Rapid Diagnostic Tests (RDTs) remain the frontline tool for malaria diagnosis, but their performance in detecting low-density infections is variable and poorly characterized at population level. Objective This study aimed to evaluate diagnostic of HRP2-based RDTs by integrating high-throughput bead-based HRP2 quantification into school-based surveys. Methods A cross-sectional was conducted three Senegalese districts (Diourbel, Tambacounda, Kédougou), enrolling 3,748 school-aged...
To describe and compare the changes in renal function between HIV-1 infected adult patients receiving antiretroviral therapy (ART) with without tenofovir (TDF). The population consisted of 40 starting a TDF-containing regimen 388 not containing TDF, followed during 42 months. estimated glomerular filtration rate (eGFR) was calculated using Cockroft–Gault MDRD equations modeled separately for first 12 months subsequent period. Between baseline months, eGFR decreased significantly TDF (-10.40...