A5080050550- HIV/AIDS Research and Interventions
- Family Caregiving in Mental Illness
- Mental Health Treatment and Access
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Dementia and Cognitive Impairment Research
- Force Microscopy Techniques and Applications
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- Maternal Mental Health During Pregnancy and Postpartum
- Carbon Nanotubes in Composites
- Mechanical and Optical Resonators
- Functional Brain Connectivity Studies
- HIV/AIDS Impact and Responses
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Diet and metabolism studies
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Advanced materials and composites
- Neurobiology of Language and Bilingualism
- Alzheimer's disease research and treatments
- Metal and Thin Film Mechanics
- Near-Field Optical Microscopy
Bordeaux Population Health
2017-2025
Université de Bordeaux
2015-2025
Inserm
2017-2025
Institut de Recherche pour le Développement
2022-2025
Oxford University Press (United Kingdom)
2024
Weatherford College
2020
Centre National de la Recherche Scientifique
1988-2017
Institut de Neurosciences Cognitives et Intégratives d’Aquitaine
2011-2017
École Pratique des Hautes Études
2011-2015
CEA LITEN
2015
Large unselected studies on representative samples of HIV-infected patients with a whole battery neuropsychological tests and cerebral MRI scan are required to assess the frequency neurocognitive impairment (NCI), determinants mild disorders (MNDs), or HIV-associated dementia (HAD) relationship between NCI findings.Investigation 400 consecutively enrolled HIV-1-infected adults from ANRS CO3 Aquitaine Cohort, using standardized chosen achieve consistency Frascati's criteria. Half had allowing...
The Mediterranean diet (MeDi) has been related to a lower risk of Alzheimer's disease; yet, the underlying mechanisms are unknown. We hypothesized that protection against neurodegeneration would translate into higher gray matter volumes, whereas specific association with preserved white microstructure suggest alternative (e.g., vascular pathways).We included 146 participants from Bordeaux Three-City study nondemented when they completed dietary questionnaire and who underwent 3-T magnetic...
Abstract Background Structural alterations of a large network characterize Alzheimer's disease (AD), but the time course these changes remains unclear. The dynamic was examined in AD preclinical phase using data from 10‐year follow‐up population‐based cohort (Bordeaux‐3City). Methods Participants received neuropsychological assessments every 2 years and two identical magnetic resonance imaging (MRI) exams at baseline 4 later. Twenty‐five incident cases were compared with 319 subjects who...
Group Interpersonal Therapy (IPT), an evidence-based treatment of depression recommended by the WHO mhGAP Intervention Guide, was implemented through a task-shifting approach in Senegal, as for depressed people living with HIV (PLWH). Since description resources used and implementation costs incurred is necessary to inform policymakers better, this study aimed estimate associated its implementation. were analyzed using "ingredients-based costing approach" from provider's perspective. We...
Abstract Finding very early biomarkers of Alzheimer's Disease (AD) to aid in individual prognosis is major interest accelerate the development new therapies. Among potential biomarkers, neurodegeneration measurements from MRI are considered as good candidates but have so far not been effective at stages pathology. Our objective investigate efficiency a MR‐based hippocampal grading score detect incident dementia cognitively intact patients. This based on pattern recognition strategy,...
Abstract Introduction Integration of services to screen and manage mental health substance use disorders ( MSD s) into HIV care settings has been identified as a promising strategy improve treatment outcomes among people living with / AIDS PLWHA ) in low‐ middle‐income countries LMIC s). Data on the extent which sites s are limited. The objective this study was assess practices for screening at clinics participating International epidemiology Databases Evaluate (Ie DEA consortium. Methods We...
Abstract Introduction “Treat All” – the treatment of all people with HIV , irrespective disease stage or CD 4 cell count represents a paradigm shift in care that has potential to end AIDS as public health threat. With accelerating implementation Treat All sub‐Saharan Africa ( SSA ), there is need for focused agenda and research identify inform strategies promoting timely uptake treatment, retention care, sustained viral suppression addressing bottlenecks impeding implementation. Methods The...
Abstract Depression is highly prevalent in people living with HIV (PLWH) and has negative consequences for daily life care. We evaluated the first time acceptability, feasibility benefits of group interpersonal therapy (IPT), combined a task-shifting approach, to treat depression PLWH Senegal. received IPT following World Health Organization protocol. Acceptability criteria were defined from literature data. The PHQ-9, WHODAS, 12-item-stigma scale used, pre- post-treatment, including 3-month...
Abstract Introduction Common mental disorders (CMDs) are highly prevalent among people with HIV. Integrating healthcare into HIV care may improve health and treatment outcomes. We describe the reported availability of screening for depression, anxiety post‐traumatic stress disorder (PTSD) at global centres participating in International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium 2020 changes sites low‐ or middle‐income countries (LMICs) between 2016/2017 2020. Methods In...
Abstract Transition to dolutegravir among 21 167 individuals experienced in antiretroviral therapy West Africa showed heterogeneous timelines and patterns. Initially reported sex disparities tended catch up over time with persisting disparities, according contributing HIV clinics. Key factors facilitating switch were male sex, age <50 years, viral suppression, regimens not based on protease inhibitors.
Introduction: Medical studies are unique in that they both theoretical and practical. The main objective was to evaluate the psychological experience quality of night-time sleep medical science students during their clinical placements. Methodology: We conducted a cross-sectional, descriptive, analytic study 7th-year at El Hadj Ibrahima Niasse University. It took place from November 11, 2023, March 21, 2024. Data were collected using questionnaire based on Google Forms. Results: A total 108...
Sexual and reproductive health issues in adolescents living with HIV (ALHIV) have been left behind care programs. ALHIV are at risk of unintended pregnancy which jeopardizes their socio-economic future, outcomes exposes newborn to transmission. A better understanding these events is needed. We studied the 18-month incidence, explored experiences among female enrolled OPTIMISE-AO cohort, nested prospective paediatric IeDEA cohort Côte d'Ivoire Burkina Faso. conducted a mixed-method study...
The prevalence of both type 2 diabetes mellitus (T2DM) and obesity is increasing among people living with HIV (PLHIV) in sub-Saharan Africa. We examined the perceptions management these two conditions PLHIV healthcare workers Côte D'Ivoire. From June to August 2022, we conducted semi-structured face-to-face interviews diagnosed T2DM and/or obesity, as well workers, one major clinics Abidjan, Cote d'Ivoire. explored topics such experiences, acceptability diagnosis PLHIV. Among professional...
<title>Abstract</title> <bold>Background. </bold>Despite the many vulnerabilities faced by female sex workers (FSWs), few studies have investigated mental health in this population, especially West Africa. This study aimed to determine frequency of psychological distress and identify associated factors among FSWs included a sexual reproductive cohort Côte d’Ivoire. <bold>Methods. </bold>The ANRS 12381 PRINCESSE project (2019-2023) was single-arm interventional ≥18 years San Pedro, d’Ivoire,...
Objectives: This study was conducted in order to determine whether food insecurity is associated with poor mental health outcomes among PLHIV Togo and Côte d’Ivoire, West Africa. Design: Cross-sectional participants enrolled the International epidemiological Databases Evaluate AIDS Africa cohort. Methods: The Household Food Insecurity Access Scale used measure insecurity. PHQ-9, GAD-7, PCL-5, AUDIT-C instruments were assess depressive symptoms, anxiety symptoms of post-traumatic stress...
The cerebral substratum of age-related cognitive decline was evaluated in an elderly-cohort followed for 12 years (n=306).Participants, free dementia, received neuropsychological assessments every two and MRI exam at baseline four later.Cognitive on broadly used tests to detect dementia: the Free Cued Selective Reminding Test (FCSRT), a verbal episodic memory task, Isaacs Set (IST), semantic fluency task.Using voxel-based approach, relationship between with 1/ grey matter volumes 2/ volume...
Structural gray matter characteristics of anxiety remain unclear. The aim this study was to assess the influence current depressive symptoms and history depression on trait anxiety.Structural magnetic resonance imaging (MRI) data from 393 individuals aged 65 years or older were used. Regions interest (ROIs) included amygdala, anterior cingulate cortex (ACC), insula, orbitofrontal (OFC), temporal cortex. Trait measured by State-Trait Anxiety Inventory (STAI). Depression using DSM-IV criteria...
Abstract Background Depression is one of the most common psychiatric disorders in people living with HIV (PLHIV). has a negative impact on both mental and physical health mainly associated suboptimal treatment outcomes. To encourage successful aging achievement 3 × 90 objectives older PLHIV, psychological domain must not be neglected. In this context as data are scarce West Africa, study aimed to evaluate prevalence factors severe depressive symptoms PLHIV region world. Methods Data from...
This study investigates relationship between regional cerebral volumes and performances over time of a categorical fluency task, in sample older adults (n = 316). Using voxel-wise technique, the local grey matter volume Isaacs Set Test (IST) scores at its early (first 15 sec) late (last phase production was analyzed with linear regression model adjusting for age, sex, educational level, ApoEɛ4 allele, handedness Grey Matter atrophy. Lower IST were associated smaller bilateral inferior...
Depression is highly prevalent in people living with HIV (PLWH) but remains under treated Sub-Saharan Africa. In this context, we conducted the first study of Group Interpersonal Therapy (IPT) to treat depression PLWH Senegal. We assessed perceptions and experiences patients group facilitators, as well barriers implementation. This was at Fann National University Hospital Center Dakar, urban capital Qualitative data were collected during implementation phase (February June 2020 then from...