A5083001505- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Dementia and Cognitive Impairment Research
- Glaucoma and retinal disorders
- Antioxidant Activity and Oxidative Stress
- Parkinson's Disease Mechanisms and Treatments
- Retinal and Optic Conditions
- Neurobiology of Language and Bilingualism
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Nutrition and Health in Aging
- Aging, Elder Care, and Social Issues
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebral Venous Sinus Thrombosis
- Neurological diseases and metabolism
- Health, Medicine and Society
- Migraine and Headache Studies
- Blood Pressure and Hypertension Studies
- Retinoids in leukemia and cellular processes
- Chronic Disease Management Strategies
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Nutritional Studies and Diet
Inserm
2015-2024
Bordeaux Population Health
2015-2024
Université de Bordeaux
2015-2024
Centre Jean Bernard
2021-2023
Nationwide Children's Hospital
2022
Centre Hospitalier Régional Universitaire de Brest
2022
Hôpital Pellegrin
2009-2015
Centre Hospitalier Universitaire de Bordeaux
2013
Sorbonne Université
2012
Institut des Maladies Neurodégénératives
2012
Abstract Objective Whereas cognitive deficits are known to be detectable long before the typical symptoms of Alzheimer's disease (AD) evident, previous studies have failed determine when functioning actually begins decline dementia. Utilizing follow‐up PAQUID study, we examined emergence first clinical over a 14‐year period dementia phase AD. Methods This study relies on case–control sample selected from cohort. Of 3,777 initial subjects cohort, 350 experienced development AD during 14 years...
OBJECTIVES: To determine whether adding cognitive impairment to frailty improves its predictive validity for adverse health outcomes. DESIGN: Four‐year longitudinal study. SETTING: The French Three‐City Study. PARTICIPANTS: Six thousand thirty community‐dwelling persons aged 65 95. MEASUREMENTS: Frailty was defined as having at least three of the following criteria: weight loss, weakness, exhaustion, slowness, and low physical activity. Subjects meeting one or two criteria were prefrail...
Background. To better understand the contribution of frailty to health-related outcomes in elderly persons, it seems valuable explore data from cohort studies across world an attempt establish a comprehensive definition. The purpose this report is show characteristics and observe its prognosis large sample French community-dwelling persons.
A better knowledge of long-term trajectories cognitive decline is a central feature the study process leading to Alzheimer's dementia. Several factors may mitigate such decline, among which education, major risk factor for disease. The aim our work was compare pattern and duration clinical before dementia in individuals with low high education within PAQUID cohort involving 20 years follow-up. sample comprises 442 participants incident disease (27.2% were male)—171 (mean age = 86.2 years;...
Abstract Motivation Diseases that progress slowly are often studied by observing cohorts at different stages of disease for short periods time. The Alzheimer's Disease Neuroimaging Initiative (ADNI) follows elders with various degrees cognitive impairment, from normal to impaired. study includes a rich panel novel tests, biomarkers, and brain images collected every 6 months as long years. relative timing the observations respect pathology is unknown. We propose general semiparametric model...
Background Lipid metabolism and particularly high-density lipoprotein (HDL) may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported associations AMD with plasma HDL other lipids, which confounded by recently HDL-related genes. We explored association lipid levels lipid-lowering medication use, taking into account most genes associated AMD. Methods The Alienor study is a population-based on eye diseases performed...
<h3>Objective:</h3> To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific functions. <h3>Methods:</h3> Participants were 4,323 women 2,764 men aged 65 over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being worst quintile distribution difference baseline score either 2- or 4-year follow-up, was assessed by Mini-Mental State Examination (MMSE, global function), Isaacs Set Test (IST,...
Abstract. Purpose: To describe dry eye disease in French elderly subjects. Methods: The Alienor Study is a population‐based study on age‐related 963 residents of Bordeaux (France), aged 73 years or more. Self‐reported and use artificial tears were documented through face‐to‐face interview. Dry symptoms assessed using the Ocular Surface Disease Index (OSDI) questionnaire tear film stability by break‐up time measurements (TBUT). Definite was defined as self‐reported eye, confirmed and/or OSDI...
Worldwide, degenerative eye diseases (age-related maculopathy (ARM), cataract, glaucoma) are the main causes of visual impairment and blindness, which contribute to disability in elderly. Mainly three types nutritional factors investigated for their potential protection against ageing: antioxidants; lutein zeaxanthin (carotenoids accumulate specifically eye); omega 3 polyunsaturated fatty acids. Few epidemiological studies have been conducted this field, particularly Europe.
To study the relationship between board game playing and risk of subsequent dementia in Paquid cohort.A prospective population-based study.In Bordeaux area South Western France.3675 non-demented participants at baseline.The during 20 years follow-up.Among 3675 baseline, 32.2% reported regular playing. Eight-hundred forty developed follow-up. The was 15% lower players than non-players (HR=0.85, 95% CI 0.74 to 0.99; p=0.04) after adjustment on age, gender, education other confounders....
While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association more controversial with age-related macular degeneration (AMD). We report the associations of lifetime ambient UVR cataract extraction and AMD.The Alienor Study population-based study 963 residents Bordeaux (France), aged 73 years or more. Lifetime was estimated from residential history Eurosun satellite-based estimations ground UVR. It divided in three groups (lower quartile, intermediate...
Multiple system atrophy (MSA) is a rare neurodegenerative disease, with limited understanding of disease progression and prognostic factors. We leveraged the data large prospective cohort MSA to study both clinical survival assess their determinants. All consecutive patients seen at French Reference Centre for since 2007 were included in an annual follow-up including Unified Rating Scale (UMSARS). used joint models evaluate risk death, mean trajectory each UMSARS subscale determine potential...
The effect of marine omega-3 PUFAs on risk stroke remains unclear.
Previous studies have suggested a lower risk for age-related maculopathy (ARM) in subjects with high dietary intake of long-chain omega-3 polyunsaturated fatty acids (PUFA). The authors report the associations ARM past intakes French elderly subjects.The Alienor Study is population-based epidemiologic study on nutrition and eye diseases performed residents Bordeaux 73 years age older. Six hundred sixty-six (1289 eyes) complete data were included analyses. was classified from retinal...
The differential diagnosis of optic disc edema at the acute phase can be challenging. OCT angiography (OCTA) is a new technology allowing visualization peripapillary vascular network and capillaries. alterations glaucoma chronic non-arteritic anterior ischemic neuropathy (NAION) were reported. However, no OCTA studies on from various causes. aim this project was to use demonstrate changes nerve head types phase. In retrospective study, patients with (NAION), papillitis or papilledema...
Purpose.: To explore the association of AMD with long-term average blood pressure (BP) parameters, including pulse (PP). Methods.: The ALIENOR study is a population-based on age-related eye diseases in 963 residents Bordeaux, France, aged 73 years or older. was graded from nonmydriatic color retinal photographs, three exclusive stages: no (1015 eyes), large soft distinct drusen and/or indistinct reticular pigmentary abnormalities (early AMD, 276 and late (66 eyes). BP parameters were...
ABSTRACT Background: Whereas the State-Trait Anxiety Inventory (STAI-Y) is probably most widely used self-reported measure of anxiety, lack current norms among elderly people appears to be problematic in both a clinical and research context. The objective present study was provide normative data for STAI-Y trait scale from large cohort identify main sociodemographic health-related determinants anxiety. Methods: completed by 7,538 community-dwelling participants aged 65 years over “Three...
To assess the associations of complement factor H (CFH) Y402H polymorphism and smoking with specific features early AMD (type, location, area).The ALIENOR study is a population-based age-related eye diseases in 963 residents Bordeaux (France), aged 73 years or more. were graded from nonmydriatic color retinal photographs. CFH was genotyped by using DNA extracted blood. Statistical analyses included 796 subjects complete data.CFH CC genotype strongly associated late neovascular (OR, 6.0; 95%...
<h3>Objective:</h3> Neuroleptics and neuroleptic-like drugs are known to induce parkinsonism, which may reveal underlying Parkinson disease (PD) in some cases. We assessed the long-term risk of developing PD after past exposure these drugs, a 15-year prospective population-based elderly cohort study. <h3>Methods:</h3> used Cox proportional hazards model assess relation between neuroleptics incident PD. All cases parkinsonism were identified by standardized procedure validated committee...