Trudy Voortman
A5006966796- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Birth, Development, and Health
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Diet, Metabolism, and Disease
- Health, Environment, Cognitive Aging
- Nutrition, Genetics, and Disease
- Vitamin D Research Studies
- Agriculture Sustainability and Environmental Impact
- Consumer Attitudes and Food Labeling
- Physical Activity and Health
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Bone health and osteoporosis research
- Frailty in Older Adults
- Fatty Acid Research and Health
- Alcohol Consumption and Health Effects
- Child Nutrition and Water Access
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Child Nutrition and Feeding Issues
- Biochemical Analysis and Sensing Techniques
Erasmus MC
2016-2025
Erasmus University Rotterdam
2016-2025
Stanford University
2024-2025
Protein Metrics (United States)
2025
University Hospital and Clinics
2024-2025
Wageningen University & Research
2011-2024
Rotterdam University of Applied Sciences
2017-2023
Zhejiang University
2021
Shanghai Institute of Nutrition and Health
2021
University of Chinese Academy of Sciences
2021
BackgroundLow-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous disease.MethodsWe did a combined analysis of three large-scale sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, the UK Biobank). We characterised...
The Rotterdam Study is an ongoing prospective cohort study that started in 1990 the city of Rotterdam, Netherlands. aims to unravel etiology, preclinical course, natural history and potential targets for intervention chronic diseases mid-life late-life. focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being...
Abstract High blood cholesterol is typically considered a feature of wealthy western countries 1,2 . However, dietary and behavioural determinants are changing rapidly throughout the world 3 using lipid-lowering medications at varying rates. These changes can have distinct effects on levels high-density lipoprotein (HDL) non-HDL cholesterol, which different human health 4,5 trends HDL over time not been previously reported in global analysis. Here we pooled 1,127 population-based studies...
Abstract Novel prognostic inflammatory markers of cancer survival and cardiovascular disease are; the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) systemic immune-inflammation index (SII). As normal values for these are unknown, our objective was to obtain reference in general population. We obtained data from a population-based prospective cohort study individuals aged 45 years over between 2002 2014. Absolute blood counts were used calculate NLR, PLR SII. All indices...
<h3>Importance</h3> Previous studies have indicated that gut microbiome may be associated with development of type 2 diabetes. However, these are limited by small sample size and insufficient for confounding. Furthermore, which specific taxa play a role in the diabetes remains unclear. <h3>Objective</h3> To examine associations composition insulin resistance large population-based setting controlling various sociodemographic lifestyle factors. <h3>Design, Setting, Participants</h3> This...
Abstract Vegan or vegetarian diets have been suggested to reduce type 2 diabetes (T2D) risk. However, not much is known on whether variation in the degree of having a plant-based versus animal-based diet may be beneficial for prevention T2D. We aimed investigate level adherence high foods and low associated with insulin resistance, prediabetes, Our analysis included 6798 participants (62.7 ± 7.8 years) from Rotterdam Study (RS), prospective population-based cohort Netherlands. Dietary intake...
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive accumulation deleterious exposures across lifespan. DNA methylation (DNAm) has been proposed as biomarker aging that conserves memory endogenous and exogenous stress during life.We examined association education level, an indicator SEP, lifestyle-related variables with four biomarkers age-dependent DNAm dysregulation: total number...
Importance Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of combination sarcopenia (sarcopenic [SO]) its association mortality still limited. Objective To investigate SO their all-cause mortality. Design, Setting, Participants This large-scale, cohort study assessed participants from Rotterdam Study March 1, 2009, to June 2014. Associations were studied using Kaplan-Meier curves, Cox...
Abstract We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals European ancestries. identified 21 unique, approximately independent lead SNPs. Fourteen SNPs are uniquely associated with one macronutrient at significance ( P < 5 × 10 −8 ), while five reach suggestive 1 −5 ) for least other macronutrient. While phenotypes genetically correlated, each phenotype carries a partially...
DNA methylation is a key epigenetic mechanism that suggested to be associated with blood lipid levels. We aimed identify CpG sites at which levels are of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), and total in 725 participants the Rotterdam Study, population-based cohort study. Subsequently, we sought replication non-overlapping set 760 participants. Genome-wide were measured whole using Illumina Methylation 450 array. Associations between beta values...
The aim of the study was to investigate relationship between serum 25(OH)D levels and axial length (AL) myopia in 6-year-old children. A total 2666 children aged 6 years participating birth-cohort Generation R underwent a stepwise eye examination. First, presenting visual acuity (VA) AL were performed. Second, automated cycloplegic refraction measured if LogMAR VA > 0.1. Serum 25-hydroxyvitamin D [25(OH)D] determined from blood using liquid chromatography/tandem mass spectrometry. Vitamin...
Intake of individual antioxidants has been related to a lower risk type 2 diabetes. However, the overall diet may contain many with additive or synergistic effects. Therefore, we aimed determine associations between total dietary antioxidant capacity and diabetes, prediabetes insulin resistance. We estimated for 5796 participants Rotterdam Study using ferric reducing ability plasma (FRAP) score. Of these participants, 4957 had normoglycaemia 839 at baseline. used covariate-adjusted...
Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies of these traits. Totally, 32 body mass index (BMI)- and 14 waist-hip ratio (WHR)-associated single nucleotide polymorphisms were genotyped, genetic risk scores (GRS) calculated in 18 cohorts European ancestry (n = 68 317). Diet was based on self-reported intakes...