Julius S. Ngwa
A5043442650- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Obesity, Physical Activity, Diet
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Statistical Methods and Inference
- Biochemical Analysis and Sensing Techniques
- Long-Term Effects of COVID-19
- Cardiovascular Health and Risk Factors
- Statistical Methods and Bayesian Inference
- Birth, Development, and Health
- Nutritional Studies and Diet
- Statistical Methods in Clinical Trials
- Adipose Tissue and Metabolism
- Respiratory Support and Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Regulation of Appetite and Obesity
- Dementia and Cognitive Impairment Research
- COVID-19 Clinical Research Studies
- Bioinformatics and Genomic Networks
- Ethics in Clinical Research
- Magnesium in Health and Disease
- Congenital Heart Disease Studies
- Genetics and Physical Performance
Children's National
2024-2025
George Washington University
2024
Howard University
2015-2023
Howard University Hospital
2016-2022
Johns Hopkins University
2017-2022
Boston University
2012-2021
Ollscoil na Gaillimhe – University of Galway
2021
University of California, San Diego
2017
Center for Systems Biology
2011
Framingham Heart Study
2011
FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest potential roles of regulating food intake. The interactive relation among variants, dietary intake and body mass index (BMI) complex results from previous often small-scale humans are highly inconsistent. We performed large-scale analyses based on data 177 330 adults (154 439 Whites, 5776 African Americans 17 115 Asians) 40 to examine: (i) association between FTO-rs9939609 variant (or...
Anorexia nervosa (AN) occurs nine times more often in females than males. Although environmental factors likely play a role, the reasons for this imbalanced sex ratio remain unresolved. AN displays high genetic correlations with anthropometric and metabolic traits. Given differences body composition, we investigated possible underpinnings of female propensity AN. We conducted sex‐specific GWAS healthy medication‐free subsample UK Biobank ( n = 155,961), identifying 77 genome‐wide significant...
Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies of these traits. Totally, 32 body mass index (BMI)- and 14 waist-hip ratio (WHR)-associated single nucleotide polymorphisms were genotyped, genetic risk scores (GRS) calculated in 18 cohorts European ancestry (n = 68 317). Diet was based on self-reported intakes...
Abstract Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific correlations amongst body fat %, mass, fat-free physical activity, glycemic traits and 17 (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, education years are negatively genetically correlated with % whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia,...
Typical survival studies follow individuals to an event and measure explanatory variables for that event, sometimes repeatedly over the course of up. The Cox regression model has been used widely in analyses time diagnosis or death from disease. associations between outcome dependent measures may be biased unless they are modeled appropriately. In this paper we explore Time Dependent Regression Model (TDCM), which quantifies effect repeated covariates analysis data. This is commonly...