Harold Snieder
A5027571680- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Heart Rate Variability and Autonomic Control
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Blood Pressure and Hypertension Studies
- Cognitive Abilities and Testing
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Obesity, Physical Activity, Diet
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Health, Environment, Cognitive Aging
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Glaucoma and retinal disorders
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Childhood Cancer Survivors' Quality of Life
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
University of Bristol
2024
Bristol Regional Medical Center
2024
Massachusetts General Hospital
2024
University of Cambridge
2000-2024
Johns Hopkins University
2022
Berkeley Public Health Division
2022
University of California, Berkeley
2022
Prevention Institute
2008-2021
Objective Twin concordance data for rheumatoid arthritis (RA) on their own provide only limited insight into the relative genetic and environmental contribution to disease. We applied quantitative methods assess heritability of RA examine evidence differences in according sex, age, clinical disease characteristics. Methods Data were analyzed from 2 previously published nationwide studies twins with conducted Finland United Kingdom. Heritability was assessed by variance components analysis....
The Estonian Biobank cohort is a volunteer-based sample of the resident adult population (aged ≥18 years). current number participants—close to 52000-—represents large proportion, 5%, population, making it ideally suited population-based studies. General practitioners (GPs) and medical personnel in special recruitment offices have recruited participants throughout country. At baseline, GPs performed standardized health examination participants, who also donated blood samples for DNA, white...
The classic twin study is sometimes described as "the perfect natural experiment" for the investigation of aetiology complex disease, but assumptions design need to be empirically tested if their results are considered unbiased and representative singleton populations. In this comparisons disease prevalence lifestyle characteristics have been made between participants in St Thomas' Hospital UK adult registry, largest volunteer register diseases ageing, a parallel population-based women. only...
Hypertension is a heritable and major contributor to the global burden of disease. The sum rare common genetic variants robustly identified so far explain only 1%–2% population variation in BP hypertension. This suggests existence more undiscovered variants. We conducted genome-wide association study 1,621 hypertensive cases 1,699 controls follow-up validation analyses 19,845 16,541 using an extreme case-control design. locus on chromosome 16 5′ region Uromodulin (UMOD; rs13333226, combined...
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Objectives In order to investigate the applicability of routine 10s electrocardiogram (ECG) recordings for time-domain heart rate variability (HRV) calculation we explored what extent these (ultra-)short capture “actual” HRV. Methods The standard deviation normal-to-normal intervals (SDNN) and root mean square successive differences (RMSSD) were measured in 3,387 adults. SDNN RMSSD assessed from (ultra)short 10s(3x), 30s, 120s compared 240s–300s (gold standard) measurements. Pearson’s...
LifeLines is a large prospective population-based three generation cohort study in the north of Netherlands. Different recruitment strategies were adopted: an index population via general practitioners, subsequent inclusion their family members, and online self-registration. Our aim was to investigate representativeness adult at baseline evaluate differences according strategy.Demographic characteristics population, recruited between 2006-2013, compared with total Netherlands as registered...
It is known that genetic variants can affect gene expression, but it not yet completely clear through what mechanisms variation mediate this expression. We therefore compared the cis-effect of single nucleotide polymorphisms (SNPs) on expression between blood samples from 1,240 human subjects and four primary non-blood tissues (liver, subcutaneous, visceral adipose tissue skeletal muscle) 85 subjects. characterized different for 2,072 probes show tissue-dependent regulation tissues: average...
The purposes of this study were to assess the long-term effect adverse childhood experiences (ACEs) on blood pressure (BP) trajectories from young adulthood and examine whether relation is explained by socioeconomic status (SES) or risk behaviors that are associated with ACEs.Systolic diastolic BPs measured up 16 times (13 average) over a 23-year period in 213 African Americans 181 European 5 38 years age. Retrospective data traumatic before 18 age collected, including abuse, neglect,...