A5070421630- Gut microbiota and health
- Inflammatory Bowel Disease
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Ginseng Biological Effects and Applications
- Gastrointestinal motility and disorders
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Tryptophan and brain disorders
- Food Security and Health in Diverse Populations
- Liver Diseases and Immunity
- Diverticular Disease and Complications
- Nutritional Studies and Diet
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Neuroendocrine regulation and behavior
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Dietary Effects on Health
- Nutrition, Genetics, and Disease
- Infant Nutrition and Health
University Medical Center Groningen
2016-2024
University of Groningen
2016-2024
Takeda (United States)
2021
Dr Falk Pharma (Germany)
2021
The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the bacteria. However, drug-microbe interactions are still understudied clinical context, where polypharmacy comorbidities co-occur. Here, we report relations between commonly used microbiome. We performed metagenomics sequencing of faecal samples from a population cohort two gastrointestinal disease cohorts. Differences users non-users were...
Differences in gut microbiota composition and function were observed between patients with inflammatory bowel disease or irritable syndrome.
Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory of the intestine, comprising Crohn’s and ulcerative colitis. By characterising metabolites in faeces, combined with faecal metagenomics, host genetics clinical characteristics, we aimed to unravel metabolic alterations IBD. Design We measured 1684 different 8 short-chain branched-chain fatty acids stool samples 424 patients IBD 255 non-IBD controls. Regression analyses were used compare concentrations...
Several gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in process, forming complex interaction with host immune system, hormones, medication and other environmental factors. Here we performed sex-specific analyses of fecal microbiota composition 1135 individuals from population-based cohort. overall females males was significantly different (p = 0.001), showing...
The gut microbiome is an ecosystem that involves complex interactions. Currently, our knowledge about the role of in health and disease relies mainly on differential microbial abundance, little known interactions context human disease. Here, we construct compare co-abundance networks using 2,379 metagenomes from four cohorts: inflammatory bowel (IBD) cohort, obese cohort two population-based cohorts. We find strengths 38.6% species co-abundances 64.3% pathway vary significantly between...
Inflammatory bowel disease (IBD) is a chronic complex of the gastrointestinal tract. Patients with IBD can experience wide range symptoms, but pathophysiological mechanisms that cause these individual differences in clinical presentation remain largely unknown. In consequence, currently classified into subtypes using characteristics. If we are to develop more targeted treatment approach, molecular need be discovered used as new drug targets. To achieve this, multiple layers data generated...
Organ transplantation is a life-saving treatment for patients with end-stage disease, but survival rates after vary considerably. There now increasing evidence that the gut microbiome linked to of undergoing hematopoietic cell transplant, yet little known about role in solid organ transplantation. We analyzed 1370 fecal samples from 415 liver and 672 renal transplant recipients using shotgun metagenomic sequencing assess microbial taxonomy, metabolic pathways, antibiotic resistance genes,...
The gut microbiome is involved in the bi-directional relationship of – brain axis. As most studies this are small and do not account for use psychotropic drugs (PTDs), we explored relations with several internalizing disorders, while adjusting PTDs other relevant medications, 7,656 Lifelines participants from Northern Netherlands (5,522 controls 491 at least one disorder). Disorders included dysthymia, major depressive disorder (MDD), any (AnyDep: dysthymia or MDD), generalized anxiety (GAD)...
Objective Both the gut microbiome and host genetics are known to play significant roles in pathogenesis of IBD. However, interaction between these two factors its implications aetiology IBD remain underexplored. Here, we report on influence Design To evaluate impact microbiota patients with IBD, combined whole exome sequencing genome shotgun 1464 faecal samples from 525 939 population-based controls. We followed a four-step analysis: (1) exome-wide microbial quantitative trait loci (mbQTL)...
Abstract Background and Aims Crohn’s disease [CD] is a chronic inflammatory disorder of the gastrointestinal tract characterised by alternating periods exacerbation remission. We hypothesised that changes in gut microbiome are associated with CD exacerbations, therefore aimed to correlate multiple features activity. Methods Faecal data generated using whole-genome metagenomic shotgun sequencing 196 patients were obtained from 1000IBD cohort [one sample per patient]. Patient activity status...
Despite treatment advancements, cardiovascular disease remains a leading cause of death worldwide. Identifying new targets is crucial for enhancing preventive and therapeutic strategies. The gut microbiome has been associated with coronary artery (CAD), however our understanding specific changes during CAD development limited. We aimed to investigate in participants without clinically manifest different risk levels patients ST-elevation myocardial infarction (STEMI).
Abstract Background Inflammatory bowel diseases (IBDs) pose a significant challenge due to their diverse, often debilitating, and unpredictable clinical manifestations. The absence of prognostic tools anticipate the future complications that require therapy intensification presents substantial burden patient private life health. We aimed explore whether gut microbiome is potential biomarker for in cohort 90 IBD patients. Methods conducted whole-genome metagenomics sequencing on fecal samples...
Emerging evidence suggests the gut microbiome's potential in predicting response to biologic treatments patients with inflammatory bowel disease (IBD). In this prospective study, we aimed predict treatment vedolizumab and ustekinumab, integrating clinical data, microbiome profiles based on metagenomic sequencing, untargeted fecal metabolomics. We identify predictive biomarkers attempted replicate microbiome-based signals from previous studies. found that utility of metabolites for was...
Abstract Background and Aims The human gastrointestinal tract harbours distinct microbial communities essential for health. Little is known about small intestinal communities, despite the intestine playing a fundamental role in nutrient absorption host-microbe immune homeostasis. We aimed to explore composition metabolic potential, context of inflammatory bowel disease [IBD]. Methods Metagenomes derived from faecal samples extensive phenotypes were collected 57 individuals with an ileostomy...
Abstract The gut microbiome is associated with diverse diseases, but the universal signature of an (un)healthy remains elusive and there a need to understand how genetics, exposome, lifestyle diet shape in health disease. To fill this gap, we profiled bacterial composition, function, antibiotic resistance virulence factors microbiomes 8,208 Dutch individuals from three-generational cohort comprising 2,756 families. We then correlated 241 host environmental factors, including physical mental...
Abstract Introduction The complexity of Inflammatory Bowel Diseases (IBD) presents challenges for the management these diseases. Predicting treatment outcomes remains difficult, leading to suboptimal and high costs. Emerging evidence suggests potential gut microbiome in predicting response biologic treatments. In this prospective study we aimed predict vedolizumab ustekinumab 79 IBD patients by integrating clinical data, profiles fecal metabolites validating findings a replication cohort 47...
Currently, 200 genetic risk loci have been identified for inflammatory bowel disease (IBD). Although these findings significantly advanced our insight into IBD biology, there has little progress in translating this knowledge toward clinical practice, like more cost-efficient drug development. Our aim was to use identify drugs that warrant further investigation treatment.We hypothesized proteins encoded by candidate genes are potential targets because information can increase successful...
Background Gene-microbiome interactions are important in aetiology and pathogenesis of inflammatory bowel disease, a chronic disorder the gastrointestinal tract consisting Crohn's disease ulcerative colitis. Scarce studies on gene-microbiome show very little overlap their results. Therefore, it is utmost importance that repeated. We aimed to replicate association between SLC39A8 [Thr]391 risk allele gut microbiome composition patients with healthy controls. Methods collected faecal samples,...
Inflammatory bowel disease (IBD) and irritable syndrome (IBS) show a large overlap in clinical presentation, which presents diagnostic challenges. As consequence, invasive burdensome endoscopies are often used to distinguish between IBD IBS. Here, we aimed develop noninvasive fecal test that can IBS reduce the number of endoscopies.We shotgun metagenomic sequencing analyze composition function gut microbiota 169 patients, 447 patients 1044 population controls measured Calprotectin (FCal),...