A5029522250- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Mental Health Research Topics
- Gastroesophageal reflux and treatments
- Pathogenesis and Treatment of Hiccups
- Advanced Chemical Sensor Technologies
- Therapeutic Uses of Natural Elements
- Eosinophilic Esophagitis
- Olfactory and Sensory Function Studies
- Congenital gastrointestinal and neural anomalies
- Health, psychology, and well-being
- Nutritional Studies and Diet
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunodeficiency and Autoimmune Disorders
- Head and Neck Cancer Studies
- Acute Lymphoblastic Leukemia research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Intestinal and Peritoneal Adhesions
- Iron Metabolism and Disorders
University Medical Center
2017-2025
Maastricht University
2016-2025
Maastricht University Medical Centre
2013-2025
Phoenix Contact (United States)
2024
Imperial College London
2022
TiFN
2014-2017
GTx (United States)
2017
Food & Nutrition
2017
Grünenthal Group (Germany)
2015
Geneeskundige en Gezondheidsdienst
2015
“Normal” for the gut microbiota For benefit of future clinical studies, it is critical to establish what constitutes a “normal” microbiome, if exists at all. Through fecal samples and questionnaires, Falony et al. Zhernakova targeted general populations in Belgium Netherlands, respectively. Gut composition correlated with range factors including diet, use medication, red blood cell counts, chromogranin A, stool consistency. The data give some hints possible biomarkers normal communities....
<h3>Background and aims</h3> Proton pump inhibitors (PPIs) are among the top 10 most widely used drugs in world. PPI use has been associated with an increased risk of enteric infections, notably <i>Clostridium difficile.</i> The gut microbiome plays important role by resisting or promoting colonisation pathogens. In this study, we investigated influence on microbiome. <h3>Methods</h3> composition 1815 individuals, spanning three cohorts, was assessed tag sequencing 16S rRNA gene. difference...
The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the bacteria. However, drug-microbe interactions are still understudied clinical context, where polypharmacy comorbidities co-occur. Here, we report relations between commonly used microbiome. We performed metagenomics sequencing of faecal samples from a population cohort two gastrointestinal disease cohorts. Differences users non-users were...
Differences in gut microbiota composition and function were observed between patients with inflammatory bowel disease or irritable syndrome.
There is a critical need for population-based prospective cohort studies because they follow individuals before the onset of disease, allowing that can identify biomarkers and disease-modifying effects, thereby contributing to systems epidemiology.This paper describes design baseline characteristics an intensively examined subpopulation LifeLines in Netherlands. In this unique subcohort, DEEP, we included 1539 participants aged 18 years older.We collected additional blood (n = 1387), exhaled...
ABSTRACT Hypermobility spectrum disorders (HSD) and hypermobility Ehlers–Danlos syndrome (hEDS) are frequently associated with gastrointestinal symptoms, although the underlying mechanisms remain unclear. This study aimed to compare antroduodenal motility in patients without HSD/hEDS. We included 239 (50 HSD/hEDS 189 non‐HSD/hEDS) symptoms undergoing manometry (ADM). The prevalence of dysmotility was not different between both groups, but enteric less common group (13% vs. 34%, p = 0.006)....
Intestinal permeability has been studied in small groups of IBS patients with contrasting findings.To assess intestinal at different sites the GI tract subtypes well-characterised and healthy controls (HC), to potential confounding factors.IBS HC underwent a multi-sugar test site-specific permeability. Sucrose excretion lactulose/rhamnose ratio 0-5 h urine indicated gastroduodenal permeability, respectively. Sucralose/erythritol 0-24 5-24 whole gut colonic Linear regression analysis was used...
To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS), several modalities of biological and clinical data must be combined. We aimed to identify profiles fecal microbiota metabolites associated with IBS delineate specific phenotypes that represent potential pathophysiological mechanisms. Fecal were measured using proton nuclear magnetic resonance (1H-NMR) spectroscopy gut microbiome shotgun metagenomic sequencing (MGS) a combined dataset 142 patients...
Background & AimsIrritable bowel syndrome (IBS) is associated with substantial costs to society. Extensive data on direct (health care consumption) and indirect (health-related productivity loss) are lacking. Hence, we examined the socioeconomic of IBS assessed which patient characteristics higher costs.MethodsCross-sectional from 3 Rome-defined Dutch cohorts (n = 419) were collected. Bootstrapped mean evaluated per using validated questionnaires (ie, medical cost questionnaire...
Abstract Background Shared decision-making (SDM) is a collaborative process between patients and healthcare professionals (HCPs) that essential to align treatment choices with patient values. The increasing variety of options for Crohn’s Disease (CD) challenges the assessment communication risks benefits both HCPs. Patient decision aids (PDAs) have been shown be effective in enhancing patient-centered care across various contexts. This study aims identify informational needs HCPs develop an...
Abstract Background Climate change is a major public health threat, with healthcare systems contributing 4-5% of global greenhouse gas (GHG) emissions. Inflammatory Bowel Disease (IBD), chronic and increasingly prevalent condition, demands extensive resources, making for this patient population notable contributor to carbon dioxide (CO2) other GHG Remote care offers an opportunity by reducing transport-related emissions through fewer outpatient visits. In study we aimed assess the footprint...
Abstract Background The Rome criteria for irritable bowel syndrome ( IBS ) have been revised and are expected to apply only the subset of III subjects with abdominal pain as predominant symptom, occurring at least once a week. aim this study was determine percentage that fulfills IV evaluate differences between ‐positive IV‐negative subjects. Methods Four hundred four completed 14‐day end‐of‐day symptom diary, Gastrointestinal Symptom Rating Scale GSRS ), Hospital Anxiety Depression Scale,...
The aim of this study was to investigate the effects three Lactobacillus plantarum strains on in-vivo small intestinal barrier function and gut mucosal gene transcription in human subjects. were selected for their differential TLR signalling tight junction protein rearrangement, which may lead beneficial a stressed mucosa. Ten healthy volunteers participated four different intervention periods: 7-day oral intake either L. WCFS1, CIP104448, TIFN101 or placebo, proceeded by 4 weeks wash-out...
Alterations in serotonin (5-HT) metabolism have been postulated to play a role the pathogenesis of irritable bowel syndrome (IBS). However, previous reports regarding 5-HT IBS are contradicting.To compare platelet poor plasma (PPP) and 5-hydroxyindole acetic acid (5-HIAA) levels their ratio large cohort patients healthy controls (HC), including IBS-subgroup analysis.Irritable HC were evaluated for fasting PPP 5-HIAA levels. Furthermore, GI-symptom diary, GSRS, quality life, anxiety...
Abstract Animal studies have shown that intestinal barrier function is compromised with aging. We aimed to assess the effects of aging on in humans vivo and ex . In this cross-sectional study, healthy subjects irritable bowel syndrome (IBS) older (65–75 years) young adult age (18–40 were compared. gastrointestinal site-specific permeability was assessed by a multi-sugar test, taking into account potential confounders. Sigmoid biopsies collected from subgroups adults elderly for Ussing...
Abstract Background Self‐rating scales are frequently used to screen for anxiety and depression in patients with irritable bowel syndrome (IBS). Different cutoff values recommended literature, guidelines have suggested the use of other screening instruments over time. The aim this study was assess correlation between most commonly psychological IBS compare custom scores these instruments. Methods Irritable ( n = 192) completed several questionnaires including Hospital Anxiety Depression...
Clinicians face difficulty in when and what order to position biologics Janus kinase inhibitors patients with anti-tumor necrosis factor-alpha (TNF) refractory ulcerative colitis (UC). We aimed compare the effectiveness safety of vedolizumab tofacitinib anti-TNF-exposed UC our prospective nationwide Initiative on Crohn Colitis Registry.Patients who failed anti-TNF treatment initiated or were identified Registry Netherlands. selected both clinical as well biochemical endoscopic disease...
Irritable bowel syndrome (IBS) is a heterogenous disorder with visceral hypersensitivity as important hallmark. It not known whether IBS patients have different epidemiological and clinical characteristics compared without hypersensitivity. Aim of our study was to compare in detail large group hyper- vs normosensitive respect characteristics.IBS (Rome III criteria) been recruited for large-scale cohort study. All from this who underwent rectal barostat procedure were included allocated based...
Disappearance of macroscopic mucosal inflammation predicts long-term outcome in Crohn's disease (CD). It can be assessed by ileocolonoscopy, which is, however, an invasive and expensive procedure. Disease activity indices do not correlate well with endoscopic noninvasive markers have a low sensitivity subgroups patients. Volatile organic compounds (VOCs) breath are increasing interest as markers. The aim this study was to investigate whether VOCs accurately differentiate between active CD...
Abstract Background Retrospective questionnaires are frequently used for symptom assessment in irritable bowel syndrome ( IBS ) patients, but influenced by recall bias and circumstantial psychological factors. These limitations may be overcome random, repeated, momentary during the day, using electronic Experience Sampling Methodology ESM ). Therefore, we compared to retrospective paper patients. Methods Twenty‐six patients (Rome III) were included, of which 16 diagnosed with panic disorder...