A5020518832- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Organic Light-Emitting Diodes Research
- Animal Behavior and Reproduction
- Organic Electronics and Photovoltaics
- Health, Environment, Cognitive Aging
- Genetic diversity and population structure
- Birth, Development, and Health
- Diet and metabolism studies
- Plant and animal studies
- Lanthanide and Transition Metal Complexes
- Gene expression and cancer classification
- Luminescence and Fluorescent Materials
- Conducting polymers and applications
- Wildlife Ecology and Conservation
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- Maternal and fetal healthcare
Institute of Science and Technology Austria
2020-2025
LabCorp (United States)
2024
PhotoBiotics (United Kingdom)
2024
Calderdale Royal Hospital
2023
University of Siena
2021
SIB Swiss Institute of Bioinformatics
2018-2020
University of Lausanne
2017-2020
The University of Queensland
2014-2020
Louisiana State University
2016
Colorado State University
2016
Jian Yang and colleagues propose a method that integrates summary data from GWAS eQTL studies to identify genes whose expression levels are associated with complex traits because of pleiotropy. They apply the five human prioritize 126 for future functional studies. Genome-wide association (GWAS) have identified thousands genetic variants traits. However, or DNA elements through which these exert their effects on often unknown. We (called SMR) summary-level quantitative trait locus (eQTL)...
Abstract Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the cause or consequence of disease, associations result confounding. We develop apply a method (called GSMR) that performs multi-SNP Mendelian randomization analysis using summary-level data from genome-wide association studies to test causal BMI, waist-to-hip ratio, cholesterols, blood pressures, height, years schooling (EduYears)...
Abstract The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other process large genotype high coverage sequencing datasets. It notably exhibits sub-linear running times with sample size, provides highly accurate haplotypes allows integrating external phasing information such as reference panels...
Genomic prediction has the potential to contribute precision medicine. However, date, utility of such predictors is limited due low accuracy for most traits. Here theory and simulation study are used demonstrate that widespread pleiotropy among phenotypes can be utilised improve genomic risk prediction. We show how a genetic predictor created as weighted index combines published genome-wide association (GWAS) summary statistics across many different apply this framework predict schizophrenia...
Abstract Background Epigenetic clocks can track both chronological age (cAge) and biological (bAge). The latter is typically defined by physiological biomarkers risk of adverse health outcomes, including all-cause mortality. As cohort sample sizes increase, estimates cAge bAge become more precise. Here, we aim to develop accurate epigenetic predictors bAge, whilst improving our understanding their epigenomic architecture. Methods First, perform large-scale ( N = 18,413) epigenome-wide...
Iridium complexes with fluorene-modified phenylpyridine ligands are resistant to crystallization and can be used in the fabrication of single layer light emitting diodes.
Significance Combining high-throughput molecular genetic data with extensive phenotyping enables the direct study of natural selection in humans. We see firsthand how and at what rates contemporary human populations are evolving. Here we demonstrate that variants associated several traits, including age first birth females body-mass index males, also reproductive success. In addition, for individuals either extreme phenotypic range have reduced fitness—the hallmark stabilizing selection....
Genome-wide association studies (GWAS) have identified thousands of loci that are robustly associated with complex diseases. The use linear mixed model (LMM) methodology for GWAS is becoming more prevalent due to its ability control population structure and cryptic relatedness increase power. odds ratio (OR) a common measure the disease an exposure (
Clutch size and egg mass are life history traits that have been extensively studied in wild bird populations, as theory predicts a negative trade-off between them, either at the phenotypic or genetic level. Here, we analyse genomic architecture of these heritable great tit (Parus major) population, using three marker-based approaches - chromosome partitioning, quantitative trait locus (QTL) mapping genome-wide association study (GWAS). The variance explained by each scales with predicted...
The genetics of human short stature Flores Island in Indonesia has a long history hominin occupation, including by the extinct Homo floresiensis and more recent settlement modern humans. Furthermore, an extant population pygmy humans, H. exhibited diminutive adult size relative to other hominins. Tucci et al. examined genetic variation among 32 individuals, 10 sequenced genomes, from pygmies living close cave where remains were discovered. These individuals exhibit signatures polygenic...
There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess allele frequencies trait-associated SNPs African, Eastern Asian, and European populations for ten using data large sample size (up ~405,000). show associated with height ([Formula: see text]), waist-to-hip ratio schizophrenia text]) significantly more differentiated than matched "control"...
Abstract Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated close relatives, SNP-heritability 0.39 0.01) conventionally-unrelated males. detect 624 near-independent genome-wide loci, contributing 0.25 0.01), which 26 X-chromosome loci explain 11.6%. Autosomal genetic variance enriched for...
Abstract Alcohol consumption is an important risk factor for multiple diseases. It typically assessed via self-report, which open to measurement error through recall bias. Instead, molecular data such as blood-based DNA methylation (DNAm) could be used derive a more objective measure of alcohol by incorporating information from cytosine-phosphate-guanine (CpG) sites known linked the trait. Here, we explore epigenetic architecture self-reported weekly units in Generation Scotland study. We...
The complex tris[1(N-ethylcarbazolyl)(3′,5′-hexyloxybenzoyl)methane](phenanthroline)europium 1 incorporates a phenanthroline ligand for electron transport and carbazole fragment in the diketonate hole transport; furthermore, six hexyloxy groups prevent crystallization allow formation of transparent clear films directly from solution; photoluminescence is nearly monochromatic, characteristic europium ion proceeds with an efficiency 50(3)%; light emitting diodes(LEDs) were fabricated using...