A5003635603- Forensic and Genetic Research
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Pacific and Southeast Asian Studies
- Mitochondrial Function and Pathology
- Forensic Anthropology and Bioarchaeology Studies
- Identification and Quantification in Food
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
- Malaria Research and Control
- Asian Studies and History
- Machine Learning in Bioinformatics
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Global Maritime and Colonial Histories
- Epigenetics and DNA Methylation
- Pleistocene-Era Hominins and Archaeology
- Genetic Associations and Epidemiology
- Race, Genetics, and Society
- Diet and metabolism studies
- Gut microbiota and health
- Birth, Development, and Health
- Genetic Mapping and Diversity in Plants and Animals
- Hemoglobinopathies and Related Disorders
- Adipose Tissue and Metabolism
Institute of Nanotechnology
2024
Eijkman Institute for Molecular Biology
2014-2023
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2015-2022
University of Indonesia
1997-2021
National Research and Innovation Agency
2021
The University of Sydney
2017-2021
Atma Jaya Catholic University of Indonesia
2019
Ministry of Research, Technology and Higher Education
2018
Islamic University of Indonesia
2017
Monash University
1988-1993
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across continent remains enigmatic. Here we report a large-scale survey autosomal from broad sample Asian human populations. Our results show that ancestry is strongly correlated with affiliations as well geography. Most populations relatedness within ethnic/linguistic groups, despite prevalent gene flow among More than 90% East (EA) haplotypes could be found in either Southeast...
Abstract The underrepresentation of non-Europeans in human genetic studies so far has limited the diversity individuals genomic datasets and led to reduced medical relevance for a large proportion world’s population. Population-specific reference genome as well genome-wide association diverse populations are needed address this issue. Here we describe pilot phase GenomeAsia 100K Project. This includes whole-genome sequencing dataset from 1,739 219 population groups 64 countries across Asia....
The early history of island Southeast Asia is often characterized as the story two major population dispersals: initial Paleolithic colonization Sahul approximately 45 ka ago and much later Neolithic expansion Austronesian-speaking farmers 4 ago. Here, in largest survey Indonesian Y chromosomes to date, we present evidence for multiple genetic strata that likely arose through a series distinct migratory processes. We genotype an extensive battery chromosome markers, including 85...
Significance The origins of the Malagasy raise questions about ancient connections between continents; moreover, because ancestors are fundamental to society, is also a heated topic around country, with numerous proposed hypotheses. This study provides comprehensive view genomic diversity (including maternal lineages, paternal and genome-wide data) based on sampling 257 villages across Madagascar. observed spatial patterns lead scenario recent sex-biased admixture Bantu Austronesian island....
Indonesia, an island nation as large continental Europe, hosts a sizeable proportion of global human diversity, yet remains surprisingly undercharacterized genetically. Here, we substantially expand on existing studies by reporting genome-scale data for nearly 500 individuals from 25 populations in Island Southeast Asia, New Guinea, and Oceania, notably including previously unsampled islands across the Indonesian archipelago. We use high-resolution analyses haplotype diversity to reveal fine...
Primaquine is the only widely used drug that prevents Plasmodium vivax malaria relapses, but adherence to standard 14-day regimen poor. We aimed assess efficacy of a shorter course (7 days) primaquine for radical cure malaria.We did randomised, double-blind, placebo-controlled, non-inferiority trial in eight health-care clinics (two each Afghanistan, Ethiopia, Indonesia, and Vietnam). Patients (aged ≥6 months) with normal glucose-6-phosphate dehydrogenase (G6PD) presenting uncomplicated were...
Linguistic, cultural and genetic characteristics of the Malagasy suggest that both Africans Island Southeast Asians were involved in colonization Madagascar. Populations from Indonesian archipelago played an especially important role because linguistic evidence suggests language branches Barito family southern Borneo, Indonesia, with closest spoken today by Ma'anyan. To test for a link between these linguistically related populations, we studied Ma'anyan other ethnic groups (including sea...
Malagasy genetic diversity results from an exceptional protoglobalization process that took place over a thousand years ago across the Indian Ocean. Previous efforts to locate Asian origin of highlighted Borneo broadly as potential source, but so far no firm source populations were identified. Here, we have generated genome-wide data two Southeast populations, Banjar and Ngaju, together with published Ocean region. We find strong support for ancestry among Banjar. This group emerged...
The settlement of Madagascar is one the most unusual, and least understood, episodes in human prehistory. was last landmasses to be reached by people, despite island's location just off east coast Africa, evidence from genetics, language culture all attests that it settled jointly Africans, more surprisingly, Indonesians. Nevertheless, extremely little known about process itself. Here, we report broad geographical screening Malagasy Indonesian genetic variation, which infer a statistically...
Abstract The Austronesian expansion, one of the last major human migrations, influenced regions as distant tropical Asia, Remote Oceania and Madagascar, off east coast Africa. identity Asian groups that settled Madagascar is particularly mysterious. While language connects to Ma’anyan southern Borneo, haploid genetic data are more ambiguous. Here, we screened genome-wide diversity in 211 individuals from surrounding Borneo. Surprisingly, characterized by a distinct, high frequency genomic...
The genetics of human short stature Flores Island in Indonesia has a long history hominin occupation, including by the extinct Homo floresiensis and more recent settlement modern humans. Furthermore, an extant population pygmy humans, H. exhibited diminutive adult size relative to other hominins. Tucci et al. examined genetic variation among 32 individuals, 10 sequenced genomes, from pygmies living close cave where remains were discovered. These individuals exhibit signatures polygenic...
The Bajo, the world's largest remaining sea nomad group, are scattered across hundreds of recently settled communities in Island Southeast Asia, along coasts Indonesia, Malaysia and Philippines. With a significant role historical trading, Bajo lived until as nomads, spending their entire lives on houseboats while moving long distances to fish trade. Along routes they traveled, intermarried with local land-based groups, leading 'maritime creolization', process whereby retained culture, but...
The Austronesian dispersal across the Indonesian Ocean to Madagascar and Comoros has been well documented, but in an unexplained anomaly, few no traces have found of expansion East Africa or Arabian Peninsula. To revisit this peculiarity, we surveyed Western Indian rim populations identify potential genetic ancestry. We generated full mitochondrial DNA genomes genome-wide genotyping data for these individuals compared them with Banjar, source population westward dispersal. find strong...
Numerous studies indicate strong associations between languages and genes among human populations at the global scale, but all broader scale genetic linguistic patterns must arise from processes originating community level. We examine variation in a contact zone on eastern Indonesian island of Sumba, where Neolithic Austronesian farming communities settled began interacting with aboriginal foraging societies ≈3,500 years ago. Phylogenetic reconstruction based 200-word Swadesh list sampled 29...
STATEMENT: In naming population groups, we think a chief aim is to use terms that the group members themselves, or find familiar and comfortable. The used in this manuscript describe populations are as historically correct possible chosen so not offend any group. Two of authors (DCP REvdR) belong Coloured population, with one (REvdR) having contributed extensively current literature on history people South Africa served Vice-President African Institute Race Relations. According 2001 census...
Languages are transmitted through channels created by kinship systems. Given sufficient time, these can change the genetic and linguistic structure of populations. In traditional societies eastern Indonesia, finely resolved cophylogenies languages genes reveal persistent movements between stable speech communities facilitated rules. When multiple present in a region postmarital residence rules encourage sustained directional movement communities, then should be channeled along uniparental...
ABSTRACT Radical cure of Plasmodium vivax infection applies blood schizontocidal therapy against the acute attack and hypnozoitocidal later relapse. Chloroquine primaquine have been used for 60 years in this manner. Resistance to chloroquine by parasite now requires partnering other schizontocides with primaquine. However, safety efficacy relapse when combined drugs not demonstrated. This randomized, open-label, relapse-controlled trial estimated administered quinine or...
<h3>Importance</h3> Latent hepatic<i>Plasmodium vivax</i>hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. <h3>Objective</h3> To examine the association of impaired<i>CYP2D6</i>genotypes CYP2D6 metabolic phenotypes with failure directly observed high-dose treatment for<i>P vivax</i>malaria relapse. <h3>Design, Setting,...
Timor, an eastern Indonesian island linking mainland Asia with Australia and the Pacific world, had a complex history, including its role as contact zone between two language families (Austronesian Trans-New Guinean), well preserving elements of rich Austronesian cultural heritage, such matrilocal marriage practices. Using array biparental (autosomal X-chromosome single-nucleotide polymorphisms) uniparental markers (Y chromosome mitochondrial DNA), we reconstruct broad genetic profile...
The Indian Ocean has long been a hub of interacting human populations. Following land- and sea-based routes, trade drove cultural contacts between far-distant ethnic groups in Asia, India, the Middle East Africa, creating one world's first proto-globalized environments. However, extent to which population mixing was mediated by is poorly understood. Reconstructing admixture times from genomic data 3,006 individuals 187 regional populations reveals close association bouts migration volumes...
Eastern Indonesia possesses more linguistic diversity than any other region in Southeast Asia, with both Austronesian (AN) languages that are of East Asian origin, as well non-Austronesian (NAN) likely Melanesian origin. Here, we investigated the genetic history human populations from seven eastern Indonesian islands, including AN and NAN speakers, relationship between genes, by means nonrecombining Y-chromosomal (NRY) mitochondrial DNA (mtDNA) analysis. We found gene pool consists...