A5080131843- Genetic Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Hearing, Cochlea, Tinnitus, Genetics
- Connexins and lens biology
- Forensic and Genetic Research
- Neurological disorders and treatments
- Genetic diversity and population structure
- Asthma and respiratory diseases
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Botulinum Toxin and Related Neurological Disorders
- Yersinia bacterium, plague, ectoparasites research
- Mast cells and histamine
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Nicotinic Acetylcholine Receptors Study
- Nutrition, Genetics, and Disease
- Metabolism and Genetic Disorders
- Helicobacter pylori-related gastroenterology studies
- Genetic Associations and Epidemiology
- Fungal and yeast genetics research
- Studies on Chitinases and Chitosanases
- Forensic Anthropology and Bioarchaeology Studies
Russian Academy of Sciences
2008-2024
Institute of Biochemistry and Genetics of Ufa Scientific Centre
2012-2024
Ufa Institute of Chemistry
2019-2024
St Petersburg University
2024
University of Science and Technology
2024
Korea University of Science and Technology
2024
Ufa University of Science and Technology
2024
Bashkir State University
2013-2023
Academy of Medical Sciences
2009
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, date the Y-chromosomal most recent common ancestor (MRCA) Africa at 254 (95% CI 192–307) kya and detect cluster major founder haplogroups narrow time interval 47–52 kya,...
The Turkic peoples represent a diverse collection of ethnic groups defined by the languages. These have dispersed across vast area, including Siberia, Northwest China, Central Asia, East Europe, Caucasus, Anatolia, Middle East, and Afghanistan. origin early dispersal history is disputed, with candidates for their ancient homeland ranging from Transcaspian steppe to Manchuria in Northeast Asia. Previous genetic studies not identified clear-cut unifying signal peoples, which lends support...
Evidence continues to accrue implicating mitochondrial dysfunction in the etiology of a number neurodegenerative diseases. For example, Parkinson's disease (PD) can be induced by toxins, and nuclear DNA (nDNA) loci linked PD have been associated with dysfunction. Although conclusions about role (mtDNA) variants vary, we argue here that this is attributable novel genetics mtDNA fact clinically relevant variation encompasses ancient adaptive polymorphisms, recent deleterious mutations, somatic...
The history of human populations occupying the plains and mountain ridges separating Europe from Asia has been eventful, as these natural obstacles were crossed westward by multiple waves Turkic Uralic-speaking migrants well eastward Europeans. Unfortunately, material records this region are not dense enough to reconstruct details population history. These considerations stimulate growing interest obtain a genetic picture demographic migrations admixture in Northern Eurasia. We genotyped...
The mutations in theGJB2(Сх26) gene make the biggest contribution to hereditary hearing loss. spectrum and prevalence of theGJB2gene are specific populations different ethnic origins. For severalGJB2 mutations, their origin from appropriate ancestral founder chromosome was shown, approximate estimations "age" obtained, presumable regions outlined. This work presents results carrier frequencies' analysis major (for European countries) mutation c.35delG (GJB2gene) among 2,308 healthy...
Hereditary spastic paraplegias represent a group of hereditary neurodegenerative disorders predominantly affecting corticospinal tracts which manifest with prominent spasticity and reduced power in the muscles lower limbs. According to clinical signs are divided into uncomplicated (classic) complicated forms, according nature inheritance – autosomal dominant, recessive X-linked. Mechanisms development depend on form could be associated misfolding proteins endoplasmatic reticulum,...
Amyotrophic lateral sclerosis (ALS) is a sporadic disease in most of the cases; 10-15% cases genetic forms are recorded. A form ALS associated with mutation
Introduction. The geographical feature of the Volga-Ural region is its location on border Europe and Asia, which, together with proximity to Caspian steppes, Ciscaucasia Siberia, facilitated as formation many migration trade routes connecting these regions in different historical periods, which turn affected ethnogenesis peoples region. Genetic features underlying inheritance human pigmentation are subject active study by molecular population geneticists. Goals. work aims distribution...
Asthma is a common complex disease with susceptibility defined through an interplay of genetic and environmental factors. Responsiveness to asthma treatment varies between individuals largely determined by variability. The polygenic score (PGS) approach enables individual risk respective response drug therapy. PGS models could help predict the using 26 SNPs pathway genes involved in metabolism glucocorticosteroids (GCS), beta-2-agonists, antihistamines, antileukotriene drugs associated...