A5040958418- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Machine Learning in Bioinformatics
- Trace Elements in Health
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Genetic diversity and population structure
- Hemoglobinopathies and Related Disorders
- Cell Image Analysis Techniques
- Environmental and Industrial Safety
- Natural Language Processing Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Arctic and Russian Policy Studies
- Genomics and Chromatin Dynamics
- Nutrition, Genetics, and Disease
- Iron Metabolism and Disorders
- Process Optimization and Integration
- Renal and related cancers
- Genomics and Rare Diseases
- Yersinia bacterium, plague, ectoparasites research
- Forensic and Genetic Research
Kharkiv State University of Food Technology and Trade
2019
Russian Academy of Sciences
2009-2017
Federal Center Research Fundamentals of Biotechnology
2017
Pranalytica (United States)
2016
Bioengineering Center
2009-2010
Abstract Recent advancements in genomics, propelled by artificial intelligence, have unlocked unprecedented capabilities interpreting genomic sequences, mitigating the need for exhaustive experimental analysis of complex, intertwined molecular processes inherent DNA function. A significant challenge, however, resides accurately decoding which inherently involves comprehending rich contextual information dispersed across thousands nucleotides. To address this need, we introduce GENA language...
Recent advancements in genomics, propelled by artificial intelligence, have unlocked unprecedented capabilities interpreting genomic sequences, mitigating the need for exhaustive experimental analysis of complex, intertwined molecular processes inherent DNA function. A significant challenge, however, resides accurately decoding which inherently involves comprehending rich contextual information dispersed across thousands nucleotides. To address this need, we introduce GENA-LM, a suite...
The history of human populations occupying the plains and mountain ridges separating Europe from Asia has been eventful, as these natural obstacles were crossed westward by multiple waves Turkic Uralic-speaking migrants well eastward Europeans. Unfortunately, material records this region are not dense enough to reconstruct details population history. These considerations stimulate growing interest obtain a genetic picture demographic migrations admixture in Northern Eurasia. We genotyped...
The three epidemiologically important Opisthorchiidae liver flukes Opisthorchis felineus, O. viverrini, and Clonorchis sinensis, are believed to harbour similar potencies provoke hepatobiliary diseases in their definitive hosts, although populations have substantially different ecogeographical aspects including habitat, preferred population structure. Lack of felineus genomic data is an obstacle the development comparative molecular biological approaches necessary obtain new knowledge about...
Mammalian forms of the transcription repressor, Kaiso, can reportedly bind methylated DNA and non-methylated CTGCNA motifs. Here we compare DNA-binding properties Kaiso from frog, fish chicken demonstrate that only methyl-CpG-binding function is evolutionarily conserved. We present several independent experimental lines evidence phenotypic abnormalities associated with xKaiso-depleted Xenopus laevis embryos are putative CTGCNA-dependent xKaiso. Our analysis suggests xKaiso does not play a...
Comorbidity or a combination of several diseases in the same individual is common and widely investigated phenomenon. However, genetic background for non-random disease combinations not fully understood. Modern technologies approaches to genomic data analysis enable investigation profile patients burdened with (polypathia, conglomerates) its comparison profiles single diseases. An association study featuring three groups various cardiovascular disorders control group relatively healthy...
Abstract An increasing number of studies emphasize the role non-coding variants in development hereditary diseases. However, interpretation such clinical genetic testing still remains a critical challenge due to poor knowledge their pathogenicity mechanisms. It was previously shown that 5′-untranslated regions (5′UTRs) can lead diseases disruption upstream open reading frames (uORFs). Here, we performed manual annotation translation initiation sites (TISs) human disease-associated genes from...
Abstract Interpretation of noncoding genomic variants is one the most important challenges in human genetics. Machine learning methods have emerged recently as a powerful tool to solve this problem. State-of-the-art approaches allow prediction transcriptional and epigenetic effects caused by mutations. However, these require specific experimental data for training cannot generalize across cell types where required features were not experimentally measured. We show here that available...
At present, the new technologies of DNA sequencing are rapidly developing allowing quick and efficient characterisation organisms at level genome structure. In this study, whole a human (Russian man) was performed using two currently present on market - Sequencing by Oligonucleotide Ligation Detection (SOLiD™) (Applied Biosystems) molecular clusters fluorescently labeled precursors (Illumina). The total number generated data resulted in 108.3 billion base pairs (60.2 from Illumina technology...
We report a family case of type II early-onset Alzheimer's disease (AD) inherited over three generations. None the patients in had mutations genes believed to be major risk factors for AD, such as APP, presenilin 1 or 2. Targeted exome sequencing 249 that were previously reported associated with AD revealed rare mutation hemochromatosis (HFE) gene known hemochromotosis. Compared previous studies, we show HFE can possess transferrin-, APOE- and APP-normal patients.
<ns4:p>Concerns of traditional prenatal aneuploidy testing methods, such as low accuracy noninvasive and health risks associated with invasive procedures, were overcome the introduction novel methods based on genetics (NIPT). These rapidly adopted into clinical practice in many countries after a series successful trials various independent submethods.</ns4:p><ns4:p> Here we present results own NIPT trial carried out Moscow, Russia. 1012 samples subjected to method aimed at measuring...
At present, the new technologies of DNA sequencing are rapidly developing allowing quick and efficient characterisation organisms at level genome structure. In this study, whole a human (Russian man) was performed using two currently present on market - Sequencing by Oligonucleotide Ligation Detection (SOLiDTM) (Applied Biosystems) molecular clusters fluorescently labeled precursors (Illumina). The total number generated data resulted in 108.3 billion base pairs (60.2 from Illumina...
A somatic cell genome was recently resequenced for a patient with renal cancer. The data were submitted to the NCBI Sequence Read Archive under accession number SRA012240. Here, we have performed SNP calling and compared it several published genomes. We found 2, 921, 724 SNPs, including 1, 472, 679 newly described ones. Among them, 63, 462 SNPs been mapped Y chromosome and, based on 18 markers, has ascribed R1a1a haplogroup predominant in Russian males. mitochondrial determined as U5a, which...
Abstract Interpretation of non-coding genomic variants is one the most important challenges in human genetics. Machine learning methods have emerged recently as a powerful tool to solve this problem. State-of-the-art approaches allow prediction transcriptional and epigenetic effects caused by mutations. However, these require specific experimental data for training can not generalize across cell types where required features were experimentally measured. We show here that available...
The need to find solutions problems on the efficient use of energy resources has been substantiated, under conditions for meeting requirements environmental sustainability production in process executing such technological operations as vaporization and rectification. We have identified prospects searching applying induced processes, which are characterized by high efficiency environmentally friendly.The kinetics temperature investigated effect from heat transfer components internal...