A5010115736- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Parasitic infections in humans and animals
- Liver physiology and pathology
- Liver Disease and Transplantation
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects and Toxicity Studies
- Helicobacter pylori-related gastroenterology studies
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Phytochemistry and Bioactivity Studies
- Hormonal Regulation and Hypertension
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- FOXO transcription factor regulation
- Cardiovascular Disease and Adiposity
- Steroid Chemistry and Biochemistry
- Parasitic Infections and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cholesterol and Lipid Metabolism
Institute of Cytology and Genetics
2016-2025
Siberian Branch of the Russian Academy of Sciences
2011-2025
Russian Academy of Sciences
2002-2025
Novosibirsk State University
2015-2025
Institute of Molecular Biology and Biophysics
2002-2025
Federal Research Center of Fundamental and Translational Medicine
2023
Background Opisthorchis felineus , viverrini and Clonorchis sinensis are epidemiologically significant food-borne trematodes endemic to diverse climatic areas. O . C both recognized be 1A group of biological carcinogens human, whereas is not. The mechanisms carcinogenesis by the liver flukes studied fragmentarily, role host parasite microbiome an unexplored aspect. Methodology/Principal findings Specific pathogen free Mesocricetus auratus hamsters were infected with microbiota adult worms,...
The liver fluke Opisthorchis felineus is a member of the triad epidemiologically relevant species trematode family Opisthorchiidae, and causative agent opisthorchiasis felinea over an extensive range that spans regions Eurasia. International Agency for Research on Cancer classifies infection with flukes viverrini Clonorchis sinensis as group 1 agents major risk factor cholangiocarcinoma. However, carcinogenic potential O. less clear. Here, we present findings support inclusion in Group list...
BackgroundA group of helminth infections, caused by liver flukes the trematode family Opisthorchiidae, were recently focus discussions at a meeting where scientists from Russia, Southeast Asia, Europe, and United States came together in Tomsk city Western Siberia (Russia) to form OPIsthorchiasis Consortium (TOPIC).This initiative starts platform raise awareness, strengthen integrated control, conduct research on neglected infectious disease that afflicts populations not only tropical regions...
The three epidemiologically important Opisthorchiidae liver flukes Opisthorchis felineus, O. viverrini, and Clonorchis sinensis, are believed to harbour similar potencies provoke hepatobiliary diseases in their definitive hosts, although populations have substantially different ecogeographical aspects including habitat, preferred population structure. Lack of felineus genomic data is an obstacle the development comparative molecular biological approaches necessary obtain new knowledge about...
The basic metabolic cytochrome P450 (CYP) system is essential for biotransformation of sterols and xenobiotics including drugs, synthesis degradation signaling molecules in all living organisms. Most eukaryotes free-living flatworms have numerous paralogues the CYP gene encoding heme monooxygenases with specific substrate range. Notably, by contrast, parasitic only one gene. role this enzyme physiology biochemistry helminths not known. flukes tapeworms are etiologic agents major neglected...
Opisthorchis felineus is the etiological agent of opisthorchiasis in humans. O. cytochrome P450 (OfCYP450) an important enzyme parasite xenobiotic metabolism. To identify potential anti-opisthorchid compound, we conducted a structure-based virtual screening natural compounds from ZINC database (n = 1,65,869) against OfCYP450. The ligands were screened OfCYP450 four sequential docking modes that resulted 361 having better score. These evaluated for Lipinski and ADMET prediction, 10 found to...
Opisthorchiasis caused by food-borne trematode Opisthorchis felineus is a substantial public health problem, with 17 million persons infected worldwide. This chronic disease associated hepatobiliary inflammation, cholangiocyte dysplasia, cholangiofibrosis, intraepithelial neoplasia, and even cholangiocarcinoma among chronically individuals. To provide first insights into the mechanism which O. infection causes precancerous liver lesions, we investigated level of oxidative stress (lipid...
Inclusion complexes of albendazole (ABZ) with the polysaccharide arabinogalactan from larch wood Larix sibirica and gmelinii were synthesized using a solid-state mechanochemical technology. We investigated physicochemical properties in solid state aqueous solutions as well their anthelmintic activity against Trichinella spiralis, Hymenolepis nаna, Fasciola hepatica, Opisthorchis felineus, mixed nematodoses sheep. Formation was demonstrated by means intrinsic solubility NMR relaxation method....
Infection with the fish-borne liver fluke Opisthorchis felineus, which is transmitted through consumption of raw or undercooked fish, results in serious damage humans. Currently, limited clinical and experimental data reveal kidney co-occurring chronic opisthorchiasis. We conducted a retrospective analysis autopsy samples over five-year period (n = 84). The aim study was to assess pathomorphological changes kidneys evaluate whether there an association between IgA nephropathy infection....
The food-borne trematode Opisthorchis felineus colonizes bile ducts of the liver fish-eating mammals including humans. Among chronically infected individuals, this opisthorchiasis involves hepatobiliary problems, chronic inflammation, periductal fibrosis, biliary intraepithelial neoplasia, and even cholangiocarcinoma. Despite numerous studies at pathomorphological level, systemic response cellular pathogenesis these disorders are not well studied. To conduct in-depth research to gain...
Currently, molecular parasitologists are searching for new agents against trematodiases. Redox metabolism is important parasites as far long-lived adult inside a mammalian host exposed to redox challenges. Antioxidants have been poorly studied anthelmintic agents, in particular the foodborne trematodes. Study of vitro activity nonenzymatic natural and synthetic antioxidants various chemical structures was performed using standard motility mortality assays juvenile Opisthorchis felineus...