A5076805339- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer therapeutics and mechanisms
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Connexins and lens biology
- Bioactive Compounds and Antitumor Agents
- Hearing, Cochlea, Tinnitus, Genetics
- Microbial Natural Products and Biosynthesis
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Marine Sponges and Natural Products
- Metal complexes synthesis and properties
- Natural product bioactivities and synthesis
- Chemical synthesis and alkaloids
- Fullerene Chemistry and Applications
- Chemical Synthesis and Analysis
- Catalytic Alkyne Reactions
- Organic Chemistry Cycloaddition Reactions
- Neuroscience of respiration and sleep
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and bioactivity of alkaloids
- Oxidative Organic Chemistry Reactions
- Chemical Reaction Mechanisms
- Graphene research and applications
N.D. Zelinsky Institute of Organic Chemistry
2021-2025
Endocrinology Research Center
2024-2025
Ministry of Health of the Russian Federation
2024
Institute of Catalysis and Petrochemistry
2016-2022
Russian Academy of Sciences
2011-2021
Photochemistry Center
2016-2021
Academy of Sciences of the Republic of Bashkortostan
2016-2020
Bashkir State Medical University
2015-2019
Institute of Biochemistry and Genetics of Ufa Scientific Centre
2002-2019
Institute of Petroleum Chemistry
2019
Early detection of aggressive pituitary neuroendocrine tumors (PitNETs) remains challenging due to the absence reliable markers that can predict disease progression. Aggressive are typically identified through long-term observation. Tumor immune microenvironment (TIME) is crucial for understanding PitNETs' heterogeneity and identifying potential predictors tumor aggressiveness. In this study, we analyzed profile micro- macroenvironment in two somatotropinomas (aggressive non-aggressive)...
An original, effective approach to the synthesis of natural and synthetic 5Z,9Z-dienoic acids in high yields (61–67%) with selectivity (>98%) was developed. The is based on use new intermolecular catalytic cross cyclomagnesiation terminal aliphatic oxygenated 1,2-dienes upon treatment Grignard reagents presence Cp2TiCl2 catalyst. High activity (5Z,9Z)-5,9-eicosadienoic acid as a human topoisomerase I inhibitor at concentrations above 0.1 μM elucidated.
Detailed study on the mechanisms of cytotoxic action various classes ionic liquids including first illustrative guide for designing ILs with targeted biological activity.
Abstract Characterization of the tumor immune microenvironment (TIME) pituitary neuroendocrine tumors (PitNETs) is crucial for understanding behavior different types PitNETs and identification possible causes their aggressiveness, rapid growth, resistance to therapy. High‐dimensional flow cytometry (FC) a promising technology studying TIME but poses unique technical challenges, especially when applied solid tissues PitNETs, in particular. This paper evaluates potential FC analyzing by...
Abstract This study addresses the reactivity of cyclic azaperoxide derivatives containing an appropriate nucleophilic function under action 1,3,5‐triaryl‐1,3,5‐triazinanes with elimination leaving groups. Criteria for predicting chemoselectivity reaction and structure products are formulated. The ring transformation 10‐aryl‐7,8,12,13‐tetraoxa‐10‐azaspiro[5.7]tridecanes 16‐aryl‐6,7,13,14,18,19‐hexaoxa‐16‐azadispiro[4.2.4 8 .7 5 ]nonadecanes catalyzed by lanthanide compounds, giving...
Triterpene acids, namely, 20,29-dihydrobetulinic acid (BA), ursolic (UA) and oleanolic (OA) were converted into C-28-amino-functionalized triterpenoids 4–7, 8a, 15, 18 20. These compounds served as precursors for the synthesis of novel guanidine-functionalized triterpene derivatives 9b–12b, 15c, 18c 20c. The influence guanidine group on antitumor properties was investigated. cytotoxicity tested five human tumor cell lines (Jurkat, K562, U937, HEK, Hela), compared with tests normal...
A new, effective catalytic system based on Co(acac)2 has been developed for [6 + 2] cycloaddition of terminal alkynes to 1,3,5,7-cyclooctatetraene give substituted bicyclo[4.2.2]deca-2,4,7,9-tetraenes in high yields (68-85%). The electrophilic activation double bonds the bicyclic products with m-CPBA is an efficient method synthesis bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols, which form key structural moieties numerous natural biologically active compounds. structures obtained compounds were...
In silico predictive software allows assessing the effect of amino acid substitutions on structure or function a protein without conducting functional studies. The accuracy in pathogenicity prediction tools has not been previously assessed for variants associated with autosomal recessive deafness 1A (DFNB1A). Here, we identify most accurate clinical significance predictions missense GJB2 (Cx26), GJB6 (Cx30), and GJB3 (Cx31) connexin genes DFNB1A. To evaluate selected (SIFT, FATHMM,...
An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-, 1,5-pentane-, 1,7-heptane-, 1,8-octane- and 1,10-decanediamines) catalyzed Sm(NO3)3/γ-Al2O3. Using flow cytometry, it shown first time that synthesized dimeric azatriperoxides are apoptosis inducers...
The synthesis of new N,N'-mononuclear bi-ligand Pd(ii) and tri-ligand Pt(ii)complexes bearing sulfanyl(phenyl, benzyl, cyclohexyl, 4-hydroxyphenyl)3,5-dimethyl-1H-pyrazole ligands has been carried out. obtained compounds were studied for apoptosis-inducing activity effect on the cell cycle Jurkat, K562, U937 neoplastic cultures conditionally normal human embryonic kidney HEK293 cells. cells showed highest sensitivity to platinum palladium complexes in comparison with cisplatin. cytotoxic...
Pathogenic variants in the GJB2 gene, encoding connexin 26, are known to be a major cause of hearing impairment (HI). More than 300 allelic have been identified gene. Spectrum and frequencies gene vary significantly among different ethnic groups worldwide. Until now, spectrum frequency pathogenic exon 1, 2 flanking intronic regions not described thoroughly Sakha Republic (Yakutia), which is located subarctic region Russia. The complete sequencing non-coding coding was performed 393 patients...
The first Z-stereoselective method for the synthesis of natural marine alkynol lembehyne C, containing a 1Z,5Z,9Z-triene moiety, in 41% yield was developed using new Ti-catalyzed cross-coupling oxygenated and aliphatic 1,2-dienes as key step. It found time that C exhibits moderate cytotoxicity against Jurkat, K562, U937, HL60 cancer cells also efficiently induces apoptosis Jurkat cells, with cell death mechanism being activated by mitochondrial pathway. inhibition cycle follows mitotic...