A5086018071- Neurogenesis and neuroplasticity mechanisms
- Nanoparticle-Based Drug Delivery
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- S100 Proteins and Annexins
- Stress Responses and Cortisol
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- Spinal Cord Injury Research
- Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Cancer Research and Treatments
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Pluripotent Stem Cells Research
- Alzheimer's disease research and treatments
- Characterization and Applications of Magnetic Nanoparticles
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
Federal Medical Research Centre for Psychiatry and Narcology
2016-2025
Ministry of Health of the Russian Federation
2016-2025
Pirogov Russian National Research Medical University
2016-2025
Endocrinology Research Center
2024-2025
University of the Free State
2024
Moscow Research and Clinical Center for Neuropsychiatry
2005-2023
Institute of Biomedical Chemistry
2023
National University of Science and Technology
2022
Institute of Higher Nervous Activity and Neurophysiology
2017
Lomonosov Moscow State University
2017
It has been suggested to use surfactant micelles as microcontainers for increasing the efficiency of neuroleptic targeting from blood flow into brain. The action haloperidol, intraperitoneally injected mice in micellar solution non-ionic block copolymer (pluronic P-85) water, increased several-fold if compared with that observed haloperidol aqueous solution. Incorporation brain-specific antibodies haloperidol-containing resulted additional drastic increase (more than by 2 orders magnitude)...
Implantation of reporter-labeled tumor cells in an immunocompetent host involves a risk their immune elimination. We have studied this effect mouse model breast cancer after the orthotopic implantation mammary gland adenocarcinoma 4T1 genetically labelled with luciferase (Luc). Mice were implanted and two derivative Luc-expressing clones 4T1luc2 4T1luc2D6 exhibiting equal vitro growth rates. In vivo, daughter clone exhibited nearly same, 4T1luc2D6, lower rate than parental cells. The...
Aggression, hyperactivity, impulsivity, helplessness and anhedonia are all signs of depressive-like disorders in humans often reported to be present animal models depression induced by stress or inflammatory challenges. However, chronic mild (CMS) clinically silent inflammation, during the recovery period after an infection, for example, coincident, but comparison behavioural molecular changes that underpin CMS vs a challenge impact combined is largely unexplored. Here, we examined whether...
Abstract Toxicological research of novel nanomaterials is a major developmental step their clinical approval. Since iron oxide magnetic nanoparticles have great potential in cancer treatment and diagnostics, the investigation toxic properties very topical. In this paper we synthesized bovine serum albumin‐coated with different sizes polyethylene glycol derivative. To prove high biocompatibility obtained number vitro toxicological tests on human fibroblasts U251 glioblastoma cells was...
High-quality, 25 nm octahedral-shaped Fe
Abstract Background Colorectal cancer (CRC) is a major burden, and prognosis determined by many demographic clinicopathologic factors. The present study aimed to construct prognostic nomogram for colorectal patients with distant metastasis. Methods metastasis diagnosed between 2010 2016 were selected from the Surveillance, Epidemiology, End Results database. Cox proportional hazards regression was used identify independent A constructed predict survival, validation performed. total of 7099...
The effectiveness of tumor therapy, especially immunotherapy and oncolytic virotherapy, critically depends on the activity host immune cells. However, various local systemic mechanisms immunosuppression operate in cancer patients. Tumor-associated involves deregulation many components immunity, including a decrease number T lymphocytes (lymphopenia), an increase levels or ratios circulating tumor-infiltrating immunosuppressive subsets [e.g., macrophages, microglia, myeloid-derived suppressor...
The middle cerebral artery occlusion (MCAO) model in rats closely imitates ischemic stroke and is widely used. Existing instrumental methods provide a certain level of MCAO guidance, but monitoring the MCA-occluding intraluminal filament position possible complications can be improved. goal this study was to develop MRI-based method simultaneous control position, blood flow intracranial vessels, hemorrhagic complications. Rats were subjected either MRI-guided (group 1, n = 51) or without MRI...
Liposomes are the most extensively used nanocarriers in cancer therapy. Despite advantages these vehicles provide over free drugs, there still limitations with regards to efficiency of liposomes delivery tumors and off-target accumulation. A better understanding nanodrugs extravasation mechanisms different tumor types normal vessels is needed improve their antitumor activity. We intravital microscopy track for fluorescent behavior xenograft models (murine breast 4T1 melanoma B16, human...
Despite significant advances in our knowledge regarding the genetics and molecular biology of gliomas over past two decades hundreds clinical trials, no effective therapeutic approach has been identified for adult patients with newly diagnosed glioblastoma, overall survival remains dismal. Great hopes are now placed on combination immunotherapy. In immunotherapeutics generally tested after standard therapy (radiation, temozolomide, steroid dexamethasone) or concurrently temozolomide and/or...