A5114376633- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Archaeology and ancient environmental studies
- Yersinia bacterium, plague, ectoparasites research
- Pleistocene-Era Hominins and Archaeology
- Fungal and yeast genetics research
- Fermentation and Sensory Analysis
- Identification and Quantification in Food
- Environmental DNA in Biodiversity Studies
- Race, Genetics, and Society
- Microbial Metabolic Engineering and Bioproduction
- Horticultural and Viticultural Research
- Pacific and Southeast Asian Studies
- Genomics and Rare Diseases
- Yeasts and Rust Fungi Studies
- Evolution and Genetic Dynamics
- Image Processing and 3D Reconstruction
- Biofuel production and bioconversion
- Mitochondrial Function and Pathology
- Ancient and Medieval Archaeology Studies
- Tuberculosis Research and Epidemiology
- Genetic Associations and Epidemiology
- Retinal and Optic Conditions
University of Minho
2016-2025
Critical Software (Portugal)
2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2024
Hospital de São João
2020
IPO Porto
2006-2019
Universidade do Porto
2006-2019
University of Leeds
2006-2016
Washington Center
2015
University of Washington
2015
Genomics of the Iberian Peninsula Ancient DNA studies have begun to help us understand genetic history and movements people across globe. Focusing on Peninsula, Olalde et al. report genome-wide data from 271 ancient individuals Iberia (see Perspective by Vander Linden). The findings provide a comprehensive time transect region. Linguistics analysis archaeological human remains dating about 7000 years ago present elucidate impact prehistoric historic migrations Europe North Africa. Science ,...
It has been argued recently that the initial dispersal of anatomically modern humans from Africa to southern Asia occurred before volcanic “supereruption” Mount Toba volcano (Sumatra) at ∼74,000 y present (B.P.)—possibly as early 120,000 B.P. We show here this “pre-Toba” model is in serious conflict with both most recent genetic evidence and archaeological South Asian sites. an alternative based on a combination analyses Africa. These data support coastally oriented eastern ∼60–50 thousand...
Although fossil remains show that anatomically modern humans dispersed out of Africa into the Near East ∼100 to 130 ka, genetic evidence from extant populations has suggested non-Africans descend primarily a single successful later migration. Within human mitochondrial DNA (mtDNA) tree, haplogroup L3 encompasses not only many sub-Saharan Africans but also all ancient non-African lineages, and its age therefore provides an upper bound for dispersal Africa. An analysis 369 complete African...
Archaeological and genetic evidence concerning the time mode of wild horse ( Equus ferus ) domestication is still debated. High levels diversity in mtDNA have been detected when analyzing control region; recurrent mutations, however, tend to blur structure phylogenetic tree. Here, we brought phylogeny highest level molecular resolution by 83 mitochondrial genomes from modern horses across Asia, Europe, Middle East, Americas. Our data reveal 18 major haplogroups (A–R) with radiation times...
Modern humans have been living in Island Southeast Asia (ISEA) for at least 50,000 years.Largely because of the influence linguistic studies, however, which a shallow time depth, attention archaeologists and geneticists has usually focused on last 6,000 years-in particular, proposed Neolithic dispersal from China Taiwan.Here we use complete mitochondrial DNA (mtDNA) genome sequencing to spotlight some earlier processes that clearly had major role demographic history region but hitherto...
Studying the genetic history of Orang Asli Peninsular Malaysia can provide crucial clues to peopling Southeast Asia as a whole. We have analyzed mitochondrial DNA (mtDNAs) control-region and coding-region markers in 447 mtDNAs from region, including 260 Asli, representative each traditional groupings, Semang, Senoi, Aboriginal Malays, allowing us test hypotheses about their origins. All groups undergone high levels drift, but phylogeographic traces nevertheless remain ancestry maternal...
The geographic origin and time of dispersal Austroasiatic (AA) speakers, presently settled in south southeast Asia, remains disputed. Two rival hypotheses, both assuming a demic component to the language dispersal, have been proposed. first these places speakers Asia with later during Neolithic, whereas second hypothesis advocates pre-Neolithic origins this family from Asia. To test two alternative models, study combines analysis uniparentally inherited markers 610,000 common single...
There are two very different interpretations of the prehistory Island Southeast Asia (ISEA), with genetic evidence invoked in support both. The "out-of-Taiwan" model proposes a major Late Holocene expansion Neolithic Austronesian speakers from Taiwan. An alternative, proposing that Glacial/postglacial sea-level rises triggered largely autochthonous dispersals, accounts for some otherwise enigmatic patterns, but fails to explain language dispersal. Combining mitochondrial DNA (mtDNA),...
The emergence of more refined chronologies for climate change and archaeology in prehistoric Africa, the evolution human mitochondrial DNA (mtDNA), now make it feasible to test sophisticated models early modern dispersals suggested by mtDNA distributions. Here we have generated 42 novel whole-mtDNA genomes belonging haplogroup L0, most divergent clade maternal line descent, analysed them alongside growing database African lineages L0's sister clade, L1'6. We propose that last common ancestor...
Abstract There has been a long-standing debate concerning the extent to which spread of Neolithic ceramics and Malay-Polynesian languages in Island Southeast Asia (ISEA) were coupled an agriculturally driven demic dispersal out Taiwan 4000 years ago (4 ka). We previously addressed this question using founder analysis mitochondrial DNA (mtDNA) control-region sequences identify major lineage clusters most likely have dispersed from into ISEA, proposing that had relatively minor impact on...
Abstract Africa was the birth-place of Homo sapiens and has earliest evidence for symbolic behaviour complex technologies. The best-attested early flowering these distinctive features in a glacial refuge zone on southern coast 100–70 ka, with fewer indications eastern until after 70 ka. Yet it Africa, not south, that witnessed first major demographic expansion, ~70–60 which led to peopling rest world. One possible explanation is important cultural traits were transmitted from south east at...
The Austronesian dispersal across the Indonesian Ocean to Madagascar and Comoros has been well documented, but in an unexplained anomaly, few no traces have found of expansion East Africa or Arabian Peninsula. To revisit this peculiarity, we surveyed Western Indian rim populations identify potential genetic ancestry. We generated full mitochondrial DNA genomes genome-wide genotyping data for these individuals compared them with Banjar, source population westward dispersal. find strong...
Abstract The origins of Ashkenazi Jews remain highly controversial. Like Judaism, mitochondrial DNA is passed along the maternal line. Its variation in Ashkenazim distinctive, with four major and numerous minor founders. However, due to their rarity general population, these founders have been difficult trace a source. Here we show that all founders, ~40% mtDNA variation, ancestry prehistoric Europe, rather than Near East or Caucasus. Furthermore, most remaining share similar deep European...
Genome-wide studies of African populations have the potential to reveal powerful insights into evolution our species, as these diverse been exposed intense selective pressures imposed by infectious diseases, diet, and environmental factors. Within Africa, Sahel Belt extensively overlaps geographical center several endemic infections such malaria, trypanosomiasis, meningitis, hemorrhagic fevers. We screened 2.5 million single nucleotide polymorphisms in 161 individuals from 13 Sahelian...
India is a patchwork of tribal and non-tribal populations that speak many different languages from various language families. Indo-European, spoken across northern central India, also in Pakistan Bangladesh, has been frequently connected to the so-called "Indo-Aryan invasions" Central Asia ~3.5 ka establishment caste system, but extent immigration at this time remains extremely controversial. South on other hand, dominated by Dravidian languages. displays high level endogamy due its strict...