A5014524595- Mitochondrial Function and Pathology
- Multiple Sclerosis Research Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Forensic and Genetic Research
- RNA Interference and Gene Delivery
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Protein purification and stability
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Animal Genetics and Reproduction
- Cytokine Signaling Pathways and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- T-cell and B-cell Immunology
- Hearing, Cochlea, Tinnitus, Genetics
- Systemic Sclerosis and Related Diseases
- Pluripotent Stem Cells Research
- Liver Diseases and Immunity
National Institute of Genetic Engineering and Biotechnology
2015-2024
NourDanesh Institute of Higher Education
2018-2023
Danesh-e-Tandorosti Iranian Institute of Higher Health
2018-2023
Universitatea Națională de Știință și Tehnologie Politehnica București
2021
Royan Institute
2012-2020
Academic Center for Education, Culture and Research
2012-2020
Tehran University of Medical Sciences
2006-2018
Islamic Azad University, Science and Research Branch
2018
University of Science and Culture
2013-2014
Tarbiat Modares University
2004-2014
Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization male lineages in Middle East southwestern Asia. At present, Iranian population is characterized by an extraordinary mix different ethnic groups speaking a variety Indo-Iranian, Semitic Turkic languages. Despite these features, only few studies have investigated multiethnic components gene pool. In this survey 938 DNAs belonging...
Can whole-exome sequencing (WES) of patients with multiple morphological abnormalities the sperm flagella (MMAF) identify causal mutations in new genes or previously identified dynein axonemal heavy chain 1 (DNAH1) gene? WES for six families men affected by MMAF syndrome allowed identification DNAH1 four distributed two out but no candidate were identified. Mutations DNAH1, an inner arm gene, have been shown to be responsible male infertility due a characteristic form asthenozoospermia...
Electrospun nanofibrous constructs based on nanoparticles and biopolymers have recently been used in tissue engineering because of their similarity to the extracellular matrix nature. In this study, electrospun chitosan-carbon quantum dot-titanium dioxide-graphene oxide (CS-CQD-TiO2-GO) mats were synthesized for use as wound dressings by electrospinning method. To increase biodegradation rate water resistance, fabricated cross-linked. SEM images showed a uniform coherent structure...
Hearing loss is the most frequent sensorineural disorder affecting 1 in 1000 newborns. In more than half of these babies, hearing inherited. Hereditary a very heterogeneous trait with about 100 gene localizations and 44 identifications for non‐syndromic loss. Transmembrane channel‐like ( TMC1 ) has been identified as disease‐causing autosomal dominant recessive at DFNA36 DFNB7/11 loci, respectively. To date, 2 18 mutations have reported cause 34 families. this report, we describe linkage to...
Objectives: Alzheimer's disease (AD) is one of the most common forms neurodegenerative diseases. Despite vast ongoing researches focusing on area, little known about novel treatments. In this study, we aimed to survey effects Capparis spinosa (C. spinosa) extract amyloid-beta peptide (Aβ)-injected rat.Methods: For purpose, hydroalcoholic extracts caper leaf and fruit were prepared. Total phenolic content, DPPH, FRAP assay accomplished determine antioxidant activity C. spinosa. HPLC analysis...
The Taguchi method is a statistical approach to overcome the limitation of factorial and fractional experiments by simplifying standardizing design. objective this study was optimize fabrication gelatin nanoparticles applying design method. Gelatin have been extensively studied in our previous works as an appropriate carrier for drug delivery, since they are biodegradable, non-toxic, not usually contaminated with pyrogens possess relatively low antigenicity. L16 orthogonal array robust...
Abstract The biotechnology industry has recently been demanding second generation of nanoparticle bioproducts such as viruses, plasmids, virus‐like particles and drug‐delivery assemblies (20–300 nm). possibility preparing uniform nanoparticles consisting proteins gelatin followed by covalent linkage avidin was investigated. Gelatin were prepared two‐step desolvation. As a colloidal system, the essential parameters in fabrication optimized Taguchi design method. However, for characterizing...
Abstract Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups present-day populations of Europe. While most subclades are older than 30 thousand years, comparatively recent coalescence time extant variation U7 (~16–19 years ago) suggests its current distribution consequence more dispersal events, despite wide geographical range across...
Human-induced pluripotent stem cells (hiPSCs) can potentially serve as an invaluable source for cell replacement therapy and allow the creation of patient- disease-specific without controversial use embryos avoids any immunological incompatibility. The generation insulin-producing pancreatic β-cells from in vitro provides unprecedented personal drug discovery transplantation diabetes. A new five-step protocol was introduced this study, effectively induced hiPSCs to differentiate into...
Development of stem cell-based therapies for the treatment type 1 diabetes would provide a renewable supply human β-cells. Human embryonic cells (ESCs) are considered to be one cell populations with sufficient proliferative capacity achieve this goal. Currently, differentiation protocols directing ESCs toward pancreatic fate employ variety expensive cytokines and inhibitors. With known significance microRNAs in islet development, we present novel cost-effective strategy which miR-375...