A5103172573- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Silk-based biomaterials and applications
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Corneal Surgery and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Hematopoietic Stem Cell Transplantation
- Periodontal Regeneration and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Nerve injury and regeneration
- Reproductive Biology and Fertility
- Extracellular vesicles in disease
Tarbiat Modares University
2015-2024
University of Tehran
2010-2024
Shahid Beheshti University of Medical Sciences
2017-2024
Qazvin Islamic Azad University
2024
Urmia University of Medical Sciences
2021
Urmia University
2021
Stem Cell Technology Research Center
2011-2020
University of Cincinnati Medical Center
2019
Shahid Sadoughi University of Medical Sciences and Health Services
2007-2018
Tehran University of Medical Sciences
2015
Abstract Exosomes derived from adipose tissue‐derived mesenchymal stem cells (AD‐MSCs) have immunomodulatory effects of T‐cell inflammatory response and reduction clinical symptoms on streptozotocin‐induced the type‐1 diabetes mellitus (T1DM). Beside control group untreated T1DM mice, a mice was treated with intraperitoneal injections characterized exosomes autologous AD‐MSCs. Body weight blood glucose levels were measured during procedure. Histopathology immunohistochemistry used for...
A combination of calcium phosphates with nanofibrous scaffolds holds promising potential for bone tissue engineering applications. In this study, nanohydroxyapatite (n-HA) was coated on the plasma-treated surface electrospun poly(l-lactide) (PLLA) nanofibers and capacity fabricated formation investigated in vitro using human cord blood derived unrestricted somatic stem cells (USSC) under osteogenic induction vivo after subcutaneous implantation. PLLA n-HA-coated (n-HA/PLLA) exhibited a...
Abstract Application of biomaterials in combination with stem cells is a novel tissue engineering approach to regenerate cartilage. The objective this study was investigate the potential poly(vinyl alcohol)/polycaprolactone (PVA/PCL) nanofiber scaffolds seeded rabbit bone marrow‐mesenchymal cell (BM‐MSC) for cartilage vitro and vivo . We tested biocompatibility mechanical properties nanofibrous using scanning electron microscope, MTT assay, tensile measurements. capacity MSC chondrogenic...
The novel strategies of skin regenerative treatment are aimed at the development biologically responsive scaffolds capable delivering multiple bioactive agents and cells to target tissues. In this study, nanofibers poly(lactic-co-glycolic acid) (PLGA) gelatin were electrospun effect parameters viz polymer concentration, acid flow rate voltage on morphology fibers investigated. PLGA encapsulating epidermal growth factor also prepared through emulsion electrospinning. core–sheath structure was...
Exosomes are natural nanovesicles with unique characteristics, such as long circulating half-life, the intrinsic ability to target tissues, biocompatibility, and minimal or no inherent systemic toxicity. Mesenchymal stem cells produce large amounts of exosomes regenerative properties more stability in human plasma. TUBO breast cancer cell lines overexpress rat HER2/neu protein.Targeted were isolated from transduced bone marrow mesenchymal cells. Doxorubicin was encapsulated into by...
Nanoparticles based on non-pathogenic viruses have opened up a novel sector in nanotechnology. Viral nanoparticles plant clear advantages over any synthetic as they are biocompatible and biodegradable self-assembled can be produced inexpensively large scale. From several such under-development platforms, only few been characterized the target-specific drugs into cells. Potato virus X is presented carrier of chemotherapeutic drug Herceptin that currently used targeted therapy (HER2+) breast...
Abstract Background: There is significant interest in using nanofibers tissue engineering from stem cells. The transdifferentiation of mesenchymal cells into the hepatic lineage a nanofibrous structure has not been reported. In this study, three dimensional scaffold introduced for differentiation human bone marrow derived (hBMSCs) hepatocytes. Methods: A composed Poly (ε‐caprolactone), collagen and polyethersulfone was fabricated by electrospinning technique. After characterization isolated...
A combination of bioceramics and polymeric nanofibers holds promising potential for bone tissue engineering applications. In the present study, hydroxyapatite (HA), bioactive glass (BG), tricalcium phosphate (TCP) particles were coated on surface electrospun poly(l-lactic acid) (PLLA) nanofibers, capacity PLLA, BG–PLLA, HA–PLLA, HA–BG–PLLA, TCP–PLLA scaffolds regeneration was investigated in rat critical-size defects using digital mammography, multislice spiral-computed tomography (MSCT)...
Electrospinning of composite polymer solutions provides fantastic potential to prepare novel nanofibers for use in a variety applications. The addition graphene (G) and oxide (GO) nanosheets bioactive polymers was found enhance their conductivity biocompatibility. Composite conductive polyaniline (PANI) polyacrylonitrile (PAN) with G GO were prepared by an electrospinning process. fabricated membranes investigated physical chemical examinations including scanning electron microscopy (SEM),...
The graphene‐based nanocomposites are considered as great candidates for enhancing electrical and mechanical properties of nonconductive scaffolds in cardiac tissue engineering. In this study, reduced graphene oxide‐silver (rGO‐Ag) (1 2 wt%) were synthesized incorporated into polyurethane (PU) nanofibers via electrospinning technique. Next, the human progenitor cells (hCPCs) seed on these vitro studies. rGO‐Ag studied by X‐ray diffraction (XRD), Raman spectroscopy, transmission electron...