A5063010036- Tuberculosis Research and Epidemiology
- Protein Tyrosine Phosphatases
- RNA Interference and Gene Delivery
- Lysosomal Storage Disorders Research
- Research on Leishmaniasis Studies
- Diabetes and associated disorders
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Metabolism, Diabetes, and Cancer
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Cancer, Hypoxia, and Metabolism
- Immunodeficiency and Autoimmune Disorders
- Advanced biosensing and bioanalysis techniques
- Diet, Metabolism, and Disease
- Diagnosis and treatment of tuberculosis
- Trypanosoma species research and implications
Tarbiat Modares University
2013-2024
Tabriz University of Medical Sciences
2021
Pasteur Institute of Iran
2002-2017
Tehran University of Medical Sciences
2016
GTx (United States)
2015
Ilam University
2010
Medical University of Ilam
2010
University of Tehran
1998-2007
Republican Scientific and Practical Centre of Pulmonology and Tuberculosis
2006
Abstract Background: Protein tyrosine phosphatase 1B (PTPN1) dephosphorylates insulin receptors and attenuates signaling. Polymorphisms in the coding sequence of PTPN1 have been variably associated with type 2 diabetes (T2D). We hypothesized that variations within promoter might contribute to development T2D related metabolic traits. Methods: screened 2.0 kb 174 patients 412 controls using PCR denaturing HPLC. Association analysis was performed between traits single-nucleotide polymorphism...
Insulin resistance is the central defect in type 2 diabetes and obesity. During development of insulin a lipid accumulation accompanied by increased PTP-1B expression muscle. The aim this study was to examine effects knockdown on signaling presence or absence palmitate C2C12 skeletal muscle cells. A stable cell line established using short hairpin RNA (shRNA) protein PTP1B. Analysis phosphorylation levels IRS-1 Akt were detected western blot. glucose uptake also measured harboring shRNA...
DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid delivery critical to make progress in vaccination. Using human papillomavirus type 16 E7 as model antigen, this study evaluated the effect peptide-polymer hybrid including PEI600-Tat conjugate novel gene system on potency antigen-specific immunity mice model. At ratio 10:50 PEI-Tat/E7DNA (w/w), responses were significantly enhanced compared with E7DNA construct induced Th1...
Recent findings have demonstrated the suitability of interferon-gamma-induced protein 10 (IP-10) or CXCL-10 as an immunotherapy tool in treatment leishmaniasis. This chemokine can overcome Leishmania (L.) infection through inducing nitric oxide (NO) production for parasite elimination. study was undertaken to investigate therapeutic effects recombinant tarentolae expressing and expression vector encoding (pcDNA-CXCL-10-EGFP) a model BALB/c mice susceptible by major. The outcome intervention...
Abstract Clin Chem Lab Med 2007;45:477–82.
Type I diabetes is an immunologically-mediated devastation of insulin producing cells (IPCs) in the pancreatic islet. Stem that produce β-cells are a new promising tool. Adult stem such as mesenchymal (MSCs) self renewing multi potent showing capabilities to differentiate into ectodermal, mesodermal and endodermal tissues. Pancreatic duodenal homeobox factor 1 (PDX1) master regulator gene required for embryonic development pancreas crucial normal islets activities adults.We induced...