A5049336307- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
- HER2/EGFR in Cancer Research
- Bacterial Infections and Vaccines
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Protein purification and stability
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Advanced Drug Delivery Systems
- Advanced Biosensing Techniques and Applications
- Pancreatic function and diabetes
- Respiratory viral infections research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Nanoparticle-Based Drug Delivery
- Biosimilars and Bioanalytical Methods
- vaccines and immunoinformatics approaches
Shahid Beheshti University of Medical Sciences
2016-2025
Pasteur Institute of Iran
2011-2012
Biotechnology Research Center
2011
Tehran University of Medical Sciences
2006-2011
Abstract Exosomes are required for the regenerative effects of human cardiosphere‐derived cells (CDCs). Studies show that they mimic cardioprotective benefits CDCs in rodents and porcine myocardial infarction (MI) models. Hypoxic preconditioning stem increases exosomes MI models by enhancing angiogenesis. Several exosomal microRNAs (miRNAs) up‐regulate response to hypoxia play a role pro‐angiogenic effects. In this study, we have demonstrated secreted under hypoxic conditions (1% O 2 days)...
ABSTRACT Breast cancer is the most common diagnosed cancer, and second cause of death among women, worldwide. HER2 overexpression occurred in approximately 15% to 20% breast cancers. Invasive biopsy method has been used for detection overexpression. HER2‐targeted imaging via an appropriate radionuclide a promising sensitive accurate identification + primary metastatic lesions. 99m Tc‐anti‐HER2 scFv can specifically target malignancies be diagnosis type metastasis as well treatment cancer. We...
Background: Cervical cancer, the third most prevalent cause of cancer in women worldwide, is associated with HPVs. The critical role E7 protein HPV-related malignancies has designated it as a strong contender for generating vaccines against HPV. Materials & methods: In this study, we developed novel live vaccine using recombinant Leishmania tarentolae expressing E7-green fluorescent (GFP) fusion protection mice HPV-associated tumors. order to transfect L. E7-GFP construct, pLEXSY-neo2 system...
In past decades, alginate-based multilayer microcapsules have been given important attention in various pharmaceutical investigations. Alginate-poly l lysine-alginate (APA) is studied the most. Due to similarity between structure of polyethyleneimine (PEI) and poly-L-lysine (PLL) also lower price PEI than PLL, this study was conducted compare efficacy linear (LPEI) branch (BPEI) forms with PLL as covering layers fabrication microcapsules. The were fabricated using electrostatic bead...
Immunotherapy is one of the treatment strategies for breast cancer, most common cancer in women worldwide. In this approach, patient's immune system stimulated to attack microscopic tumors and control metastasis. Here, we used interferon γ-induced protein 10 (IP-10), which induces strengthens antitumor immunity, as an immunotherapeutic agent. We employed Leishmania tarentolae, a nonpathogenic lizard parasite that lacks ability persist mammalian macrophages, was live delivery carrying It has...
To control cervical cancer, efficient vaccination against human papillomavirus (HPV) is highly required. Despite the advantages and safety of protein vaccines, additional strategies to enhance their immunogenicity are needed. E7 a transforming which represents perfect target antigen for vaccines or immunotherapies. Heat shock proteins (HSPs) facilitate cellular immune responses antigenic peptides bound them. Regarding previous studies, with purified HSP/antigen complexes efficiently elicit...