A5058045726- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Liver physiology and pathology
- Ovarian function and disorders
- Wound Healing and Treatments
- Pluripotent Stem Cells Research
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Glutathione Transferases and Polymorphisms
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Knee injuries and reconstruction techniques
- Sperm and Testicular Function
- 3D Printing in Biomedical Research
- Corneal Surgery and Treatments
- MicroRNA in disease regulation
- Biomarkers in Disease Mechanisms
- Nerve injury and regeneration
- Wnt/β-catenin signaling in development and cancer
Academic Center for Education, Culture and Research
2015-2024
Biotechnology Research Center
2013-2024
Shahid Beheshti University
2023
Research Institute for Geo-Hydrological Protection
2020
Guilan University of Medical Sciences
2012-2013
Tarbiat Modares University
2005-2012
University of Guilan
2012
Abstract Background Cell-free Mesenchymal stromal cells (MSCs) have been considered due to their capacity modulate the immune system and suppress cytokine storms caused by SARS-CoV-2. This prospective randomized double-blind placebo-controlled clinical trial aimed assess safety efficacy of secretome derived from allogeneic menstrual blood (MenSCs) as a treatment in patients with severe COVID-19 . Methods Patients were (1:1) either MenSC-derived or control group. Subjects received five...
Abstract Background: There is significant interest in using nanofibers tissue engineering from stem cells. The transdifferentiation of mesenchymal cells into the hepatic lineage a nanofibrous structure has not been reported. In this study, three dimensional scaffold introduced for differentiation human bone marrow derived (hBMSCs) hepatocytes. Methods: A composed Poly (ε‐caprolactone), collagen and polyethersulfone was fabricated by electrospinning technique. After characterization isolated...
Retrograde flow of menstrual blood cells during menstruation is considered as the dominant theory for development endometriosis. Moreover, current evidence suggests that endometrial-derived stem are key players in pathogenesis In particular, endometrial stromal have been suggested to be involved this disease. Here, we aimed use blood, a novel source cells, investigate whether from endometriosis (E-MenSCs) and non-endometriosis (NE-MenSCs) women differed regarding their morphology, CD marker...
In recent decades, stem cell therapy has been introduced as a novel therapeutic approach for patients suffering from bone disorders. Recently, menstrual blood identified an easily accessible and recycled source. However, the osteogenic differentiation capacity of blood-derived cells (MenSCs) compared with other adult remained unsolved. The aim this study was to investigate MenSCs marrow-derived mesenchymal (BMSCs) in presence human platelet releasate (HPR). Our results showed that were...
Abstract Although natural killer (NK) cells play a crucial role in the maintenance of successful pregnancy, their cytotoxic activity should be tightly controlled. We hypothesized that endometrial mesenchymal stromal/stem (eMSCs) could potentially attenuate functional features NK cells. Herein, we assessed immunomodulatory effects menstrual blood-derived (MenSCs), as surrogate for eMSCs, on function. Our results showed MenSCs induced proliferation However, IFN-γ/IL-1β pretreated significantly...
Menstrual blood has been introduced as an easily accessible and refreshing stem cell source with no ethical consideration. Although recent works have shown that menstrual cells (MenSCs) possess multi lineage differentiation capacity, their efficiency of hepatic in comparison to other resources not addressed so far. The aim this study was investigate capacity MenSCs compared bone marrow-derived (BMSCs) under protocols developed by different concentrations hepatocyte growth factor (HGF)...
In recent years, the advantages of menstrual blood-derived stem cells (MenSCs), such as minimal ethical considerations, easy access and high proliferative ability, have inspired scientists to investigate potential MenSCs in cell therapy different diseases. order characterize potency these for future liver diseases, we examined differentiate into hepatocytes, using protocols. First, immunophenotyping properties osteoblasts, adipocytes chondrocytes were evaluated. Thereafter, differentiation...
Abstract Aim: Menstrual blood stromal stem cells (MBSCs) have been demonstrated to exhibit cell properties such as the capability for self‐renewal and multipotency, allowing multilineage differentiation. In addition, this type has various immunomodulatory effects. study, we examined potential effect of MBSCs on proliferation peripheral mononuclear (PBMCs) in allogeneic mixed lymphocyte reaction (MLR). Materials Methods: was collected from healthy donors after menstrual flow initiated its...
Introduction The recent identification of menstrual blood-derived stem cells (MenSCs) as a unique population has created enormous promise for tissue engineering. In this study, after characterization MenSCs in comparison with bone marrow-derived (BMSCs), the potential seeded into electrospun, biodegradable, nanofibrous scaffolds order to engineer cartilage was evaluated. Methods and BMSCs were isolated by discontinuous density gradient centrifugation plastic adherence. After compared BMSCs,...
Abstract Objectives To characterize potency of menstrual blood‐derived stem cells (MenSCs) for future cell therapies, we examined differentiation potential MenSCs into adipocytes. Materials and methods Differentiation in comparison to bone marrow ( BMSC s) was assessed conventional culture medium. adipocytes improved using different combinations growth factors hormones. Results First, demonstrated that preserve their appearance karyotypic stability during passages. Although these express...
In this study characterization of endothelial cells differentiated from human bone marrow mesenchymal stem (hBMCs) was investigated in relation to their capillary network formation potential. Differentiation performed presence vascular growth factor (VEGF) and insulin like factor-1 (IGF-1). A panel cellular molecular markers used for the cells. The were strongly positive von Willebrand (vWF) receptor 2 (VEGFR2) when measured at protein mRNA levels. Development found be associated with...
Abstract Menstrual blood is easily accessible, renewable, and inexpensive source of stem cells that have been interested for cell therapy neurodegenerative diseases. In this study, we showed conversion menstrual (MenSCs) into clonogenic neurosphere‐ like (NSCs), which can be differentiated glial‐like cells. Moreover, differentiation potential MenSCs glial lineage was compared with bone marrow (BMSCs). Differentiation individual converted NSCs derived from or BMSCs investigated using...