A5105876049- Hepatitis C virus research
- Forensic and Genetic Research
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Hemoglobinopathies and Related Disorders
- Hepatitis B Virus Studies
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Evolutionary Psychology and Human Behavior
- Genetic diversity and population structure
- Demographic Trends and Gender Preferences
- PARP inhibition in cancer therapy
- Malaria Research and Control
- Insurance, Mortality, Demography, Risk Management
- Global Maternal and Child Health
- Systemic Lupus Erythematosus Research
- Yersinia bacterium, plague, ectoparasites research
- Mycobacterium research and diagnosis
- Genetic Associations and Epidemiology
- Linguistic Studies and Language Acquisition
- RNA modifications and cancer
- Historical Geopolitical and Social Dynamics
- Gene expression and cancer classification
- Cell death mechanisms and regulation
- Names, Identity, and Discrimination Research
Istituto di Genetica Molecolare
2003-2020
National Research Council
2011-2020
National Academies of Sciences, Engineering, and Medicine
2012-2019
Massachusetts General Hospital
2012
Broad Institute
2012
University of Maryland, Baltimore
2012
Czech Academy of Sciences, Institute of Molecular Genetics
2012
University of Pavia
1990-2011
Institutt for Grafiske Medier
2011
Istituto Superiore di Sanità
2011
Occult HBV infection is characterized by the persistence of DNA in liver individuals negative for surface antigen (HBsAg). may exist hepatocytes as a free genome, although factors responsible very low viral replication and gene expression usually observed this peculiar kind are mostly unknown. Aims study were to investigate whether genomic variability might account HBsAg negativity inhibition occult carriers, verify vitro capability strains. We studied isolates from 17 patients, 13 with 4...
Invasive species represent a global concern for their rapid spread and the possibility of infectious disease transmission. This is case invader Aedes albopictus, Asian tiger mosquito. vector medically important arboviruses, notably chikungunya (CHIKV), dengue (DENV) Zika (ZIKV). The reconstruction complex colonization pattern this mosquito has great potential mitigating its and, consequently, risks.Classical population genetics analyses Approximate Bayesian Computation (ABC) approaches were...
Sequence heterogeneity of hepatitis C virus (HCV) is unevenly distributed along the genome, and maximal variation confined to a short sequence HCV second envelope glycoprotein (E2), designated hypervariable region 1 (HVR1), whose biological function still undefined. We prospectively studied serological responses synthetic oligopeptides derived from HVR1 sequences patients with acute chronic infection obtained at baseline after defined follow-up period. Extensive cross-reactivity for...
DNA ligase I-deficient 46BR.1G1 cells show a delay in the maturation of replicative intermediates resulting accumulation single- and double-stranded breaks. As consequence ataxia telangiectasia mutated protein kinase (ATM) is constitutively phosphorylated at basal level. Here, we use as model system to study cell response chronic replication-dependent damage. Starting from proteomic approach, demonstrate that phosphorylation level factors controlling constitutive alternative splicing...
Hepatitis C virus (HCV) infection is a dynamic process during which molecular variants are continously selected as the result of adaptation to host. Understanding nature HCV genetic variation central current theories pathogenesis and immune response. We prospectively studied hypervariable region 1 (HVR1) in E2 gene 36 hepatitis patients, including 10 asymptomatic carriers, followed up for 2 years. Sequence changes single consecutive serum samples were assessed correlated with clinical...
Summary Surname distributions were studied in order to reconstruct human migration patterns. Zones of sharp change surname frequencies ‐ presumably barriers gene flow detected by the statistical technique wombling (Barbujani et al. 1989), using data from consanguineous marriages (1910‐64) collected 280 Italian dioceses which we grouped into 80 provinces. The 28 observed boundaries compared with physical (geographical) and cultural (linguistic) barriers, 57 alleles same territorial...
Human T-cell lymphotropic virus (HTLV) type II has spread among intravenous drug users (IDUs), many of whom are coinfected with HIV-1. We have investigated the rate HTLV-II infection in 3574 Italian IDUs screened for HIV-1, HTLV-I, and from 1986 to present. proviral load was determined by a real-time polymerase chain reaction specifically designed tax amplification. The frequency 6.7% HIV-1-positive subjects 1.1% HIV-1-negative (P < 0.0001). For examination AIDS progression, group 437...
COMT (Catechol-O methyltransferase) gene is one of the key players in synaptic plasticity and learning memory mechanisms. A single nucleotide polymorphism (rs4680; G to A) coding region causes Val158Met aminoacid substitution th
Long non-coding RNAs are recognized as an important class of regulatory molecules involved in a variety biological functions. However, the mechanisms long genes expression still poorly understood. The characterization genomic features is crucial to get insight into their function. In this study, we exploited recent annotations by GENCODE characterize and splicing comparison with protein-coding ones, both human mouse. Our analysis highlighted differences between two classes terms gene...
SummaryUsing data from the 1961 Italian census, study of fertility in Sardinia when malaria was endemic shows differential between women living areas with differing degrees malaria. Cultural factors measured by women's level education are negatively correlated fertility, just as 'urban' character area which lived has a lowering effect on rate. The hypothesis mortality according to social class, affecting lower-class and particular more prolific among them, seems be supported analysed through...
Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently MI through genome-wide association studies were
We analyze the geographic location of 77,451 different Italian surnames (17,579,891 individuals) obtained from lists telephone subscribers year 1993.By using a specific neural network analysis (Self-Organizing Maps, SOMs), we automatically identify origin 49,117 surnames. To validate methodology, compare results to study, previously conducted, on same database, with accurate supervised methods. By comparing results, find an overlap 97%, meaning that SOMs methodology is highly reliable and...
In the past few years, role of long noncoding RNAs (lncRNAs) in tumor development and progression has been disclosed although their mechanisms action remain to be elucidated. An important contribution comprehension lncRNAs biology cancer could obtained through integrated analysis multiple expression datasets. However, growing availability public datasets requires new data mining techniques integrate describe relationship among data. this perspective, we explored powerness Association Rule...
The influenza A virus (IAV) NS1 protein is one of the major regulators pathogenicity, being able to suppress innate immune response and host synthesis. In this study we identified human micro RNA hsa-miR-1307-3p as a novel potent suppressor expression replication. Transcriptomic analysis indicates that also negatively regulates apoptosis promotes cell proliferation. addition, mutation in gene A(H1N1)pdm09 strains circulating Italy 2010-11 season, which enabled escape inhibition, conferring...
The protein profiles of bronchoalveolar lavage fluid (BALf) patients belonging to three selected subsets Polymyositis/Dermatomyositis (PM/DM) have been compared by using a combination 2-DE and MALDI-TOF/MS or LC-MS/MS. Our study examined the hypothesis that there were distinct differences in expression related phenotype. From among 323+/-51 spots may represent most highly expressed proteins BALf these patients, 24 unique isolated identified. In particular, 9 present PM/DM only; 12 exclusive...
The role of natural selection in maintaining the thalassemia polymorphism is examined a southern Italy district, past affected by malaria endemia. Haldane's hypothesis that heterozygotes enjoy more protection than normal homozygotes against risk infection, seems to be confirmed this indirect study at population level. higher number children born women who lived highly endemic villages, where highest proportion occurs, supports woman fertility contributes maintenance. joint effects acquired...
Multiple Sclerosis (MS) is a chronic disease of the central nervous system, etiology which, although not completely known, involves inflammation and autoimmunity. In present study we aimed at identifying molecular markers apoptosis, cellular stress DNA damage in isolated peripheral blood mononuclear cells (PBMCs) MS patients. The analysis was carried on 19 relapsing-remitting untreated patients 13 healthy individuals. We investigated emergency-driven synthesis poly(ADP-ribose) (PAR),...