Lorenzo Cavagna
A5014762324- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Skin Diseases and Diabetes
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Gout, Hyperuricemia, Uric Acid
- Sarcoidosis and Beryllium Toxicity Research
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Monoclonal and Polyclonal Antibodies Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical Imaging and Pathology Studies
- Urticaria and Related Conditions
- Pulmonary Hypertension Research and Treatments
- Dermatological and Skeletal Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Long-Term Effects of COVID-19
- Genetic Neurodegenerative Diseases
- Autoimmune Bullous Skin Diseases
Policlinico San Matteo Fondazione
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
University of Pavia
2016-2025
Center for Rheumatology
2016-2024
Universidad de Cantabria
2018-2024
Universitat Autònoma de Barcelona
2024
Universitätsklinikum Erlangen
2023
NIHR Leeds Musculoskeletal Biomedical Research Unit
2021-2023
University of Zurich
2023
ERN GUARD-Heart
2022
<h3>Objective</h3> To assess the epidemiology of gout and hyperuricaemia in Italian general population during years 2005–2009. <h3>Methods</h3> Using primary care database (Health Search/CSD Longitudinal Patient Database), prevalence, incidence recurrence rates and/or (serum urate level >360 mmol/l (6 mg/dl)) outpatients aged ≥18 2005–2009 were estimated. Rates together with 95% CI measured overall stratified by age, gender calendar year. The characteristics patients newly diagnosed...
Antisynthetase syndrome (ASSD) is a rare clinical condition that characterized by the occurrence of classic triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether presence ARS might affect presentation, evolution, outcome ASSD. In this study, we retrospectively recorded time onset, characteristics, clustering triad findings, survival...
Anti Jo-1 antibodies are the main markers of antisynthetase syndrome (ASSD), an autoimmune disease clinically characterized by occurrence arthritis, myositis, and interstitial lung (ILD). These manifestations usually co-occur (for practical purpose complete forms) in same patient, but cases with only 1 or 2 these findings incomplete have been described. In forms, ex novo further is possible, although frequencies timing not still defined. The aim this international, multicenter, retrospective...
Objective To determine which clinical, laboratory, and imaging features most accurately distinguished gout from non‐gout. Methods We performed a cross‐sectional study of consecutive rheumatology clinic patients with ≥1 swollen joint or subcutaneous tophus. Gout was defined by synovial fluid tophus aspirate microscopy certified examiners in all patients. The sample randomly divided into model development (two‐thirds) test (one‐third). Univariate multivariate association between clinical...
Objective To examine the performance of ultrasound (US) for diagnosis gout using presence monosodium urate monohydrate (MSU) crystals as gold standard. Methods We analyzed data from Study Updated Gout Classification Criteria (SUGAR), a large, multicenter observational cross‐sectional study consecutive subjects with at least 1 swollen joint who conceivably may have gout. All underwent arthrocentesis; cases were confirmed MSU crystals. Rheumatologists or radiologists blinded regard to results...
Neutrophil extracellular traps (NET) expose modified antigens for autoantibodies in vasculitis. Little is known about levels and removal pathways of NET systemic lupus erythematosus (SLE), especially nephritis (LN). We determined circulating defined large subsets patients with incident SLE (iSLE), some whom had new-onset nephritis.Serum (ELISA), DNase1/DNase1L3 DNase activity (functional assay) were 216 iSLE [103 LN (iLN)], 50 other primary glomerulonephritis, healthy controls. Ex vivo...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly reached pandemic proportions. Given that the main target of SARS-CoV-2 are lungs leading to severe pneumonia with hyperactivation inflammatory cascade, we conducted a prospective study assess alveolar status in patients moderate COVID-19.Diagnostic bronchoalveolar lavage (BAL) was performed 33 adult infection by real-time PCR on nasopharyngeal swab admitted Intensive care unit (ICU) (n = 28) and Intermediate Medicine Ward...
Objective To perform external validation of a provisional definition disease flare in patients with gout. Methods Five hundred nine gout were enrolled cross‐sectional study during routine clinical care visit at 17 international sites. Data collected to classify as experiencing or not flare, according definition. A local expert rheumatologist performed the final independent adjudication status. Sensitivity, specificity, predictive values, and receiver operating characteristic ( ROC ) curves...
Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy manage pandemic. Although none of currently approved vaccines are live-attenuated, several reports disease flares, waning protection, acute-onset syndromes emerged as short-term adverse events after...
Abstract Introduction/Aims In this study we investigated COVID‐19 vaccination–related adverse events (ADEs) 7 days postvaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune disorders (SAIDs). Methods Seven‐day vaccine ADEs were collected an international patient self‐reported e‐survey. Descriptive statistics obtained multivariable regression was performed. Results Ten thousand nine hundred respondents analyzed (1227 IIM cases, 4640 SAID 5033...
To develop and evaluate the performance of multicriteria decision analysis (MCDA)-driven candidate classification criteria for antisynthetase syndrome (ASSD). A list variables associated with ASSD was developed using a systematic literature review then refined into an key domains by myositis interstitial lung disease (ILD) experts. This used to create preferences surveys in which experts were presented pairwise comparisons clinical vignettes asked select case that more likely represent ASSD....
Abstract Objectives To comprehensively compare the disease burden among patients with RA, PsA and AS using Patient-Reported Outcome Measurement Information System (PROMIS) scores to identify distinct patient clusters based on comorbidity profiles PROMIS outcomes. Methods Data from global COVID-19 Vaccination in Autoimmune Diseases (COVAD) 2 e-survey were analysed. Patients or undergoing treatment DMARDs included. (global physical health, mental fatigue 4a function short form 10a),...
To describe the longterm effectiveness and safety of cyclosporine (CYC) in patients with anti-Jo1-positive antisynthetase syndrome corticosteroid-refractory interstitial lung disease (ILD).All anti-Jo1 referred to our division between June 1991 February 2010 were retrospectively evaluated for ILD. ILD was assessed using pulmonary function tests (PFT) and/or high-resolution computed tomography (HRCT). Kazerooni score used evaluate HRCT extent Prednisone first-line treatment all cases (1...
In the last decades a large amount of evidence linked rheumatoid arthritis (RA) to atherosclerosis. fact, RA patients have an increased risk cardiovascular events that is not fully explained by other classic factors. and atherosclerosis may share several common pathomechanisms inflammation undoubtedly plays primary role. The proinflammatory cytokines such as tumor necrosis factor alpha interleukin-6, involved in pathogenesis RA, are also independently predictive subsequent disease (CVD)....
Background The use of nephrotoxic drugs can further worsening renal function in chronic kidney disease (CKD) patients. It is therefore imperative to explore prescribing practices that negatively affect CKD Aim To analyze the patients a general population Southern Italy during years 2006–2011. Methods practice “Arianna” database contains data from 158,510 persons, registered with 123 practitioners (GPs) Caserta. were identified searching: CKD-related ICD-9 CM codes among causes...