A5043873380- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Neuroendocrine Tumor Research Advances
- Nitric Oxide and Endothelin Effects
- Growth Hormone and Insulin-like Growth Factors
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Urticaria and Related Conditions
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Celiac Disease Research and Management
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
University of Genoa
2016-2021
Ospedale Policlinico San Martino
2016-2021
Martin University
2021
Neutrophil extracellular traps (NET) expose modified antigens for autoantibodies in vasculitis. Little is known about levels and removal pathways of NET systemic lupus erythematosus (SLE), especially nephritis (LN). We determined circulating defined large subsets patients with incident SLE (iSLE), some whom had new-onset nephritis.Serum (ELISA), DNase1/DNase1L3 DNase activity (functional assay) were 216 iSLE [103 LN (iLN)], 50 other primary glomerulonephritis, healthy controls. Ex vivo...
Anti-parietal cell antibodies (APCA) are a serologic marker of autoimmune gastritis. Their prevalence in healthy individuals is not well defined.We evaluated APCA 515 blood-donors by rat/primate tissue indirect immunofluorescence (IIF), enzyme-linked immunosorbent assay (ELISA), and immunoblot.Fifty-three (10.3%) subjects were positive for at least one method: 18 only ELISA, 10 rodent IIF, primate IIF; ELISA IIF. Two both IIF methods, three triple positive. positivity was confirmed...
Human leucocyte antigen-G (HLA-G) is a nonclassical class I major histocompatibility complex (MHC) molecule characterized by immunoregulatory and tolerogenic functions. Membrane-bound HLA-G expressed on the surface of different cell populations in both physiological pathological conditions. Systemic sclerosis (SSc) multisystem autoimmune disease widespread tissue fibrosis, vascular lesions immunological alterations. lupus erythematosus prototypic systemic affecting virtually any organ...
Background: The use of thyrotropin and free thyroid hormone assays to evaluate function is widespread, but in some situations the results are inconsistent with patient's status. Summary: A 35-year-old woman a known diagnosis chronic autoimmune thyroiditis was referred authors' clinic at week 26 her second pregnancy. patient clinically euthyroid. Consistent this, serum (TSH) normal (0.79 mIU/L), she had elevated hormones—free triiodothyronine (fT3) thyroxine (fT4)—as determined by one-step...
Circulating autoantibodies of IgG2 isotype predominate in Systemic Lupus Erythematosus (SLE) and concur to the development renal lesions characteristic Nephritis (LN). Anti-dsDNA anti-histones IgG2, together with anti-podocyte proteins (i.e., α-enolase) are major serum glomeruli LN patients. The mechanisms underlying autoantibody formation switching SLE unknown. A issue is how DNA/histones externalized from cell nucleus, driving autoimmune response. Neutrophil Extracellular Traps (NETs) have...
Since the novel coronavirus disease 2019 (COVID-19) has been declared a pandemic, possibility of recurrence after recovery become debated issue. We report case an 84-years-old male patient who was admitted to our hospital for dyspnea and fever. Lab clinical workout showed that he had COVID-19. After full symptoms double negative nasopharyngeal swab severe acute respiratory syndrome-related 2 (SARS-CoV-2) by realtime polymerase chain reaction assay, discharged from hospital. One month later,...