A5038942338- Prostate Cancer Treatment and Research
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Functional Brain Connectivity Studies
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Amyotrophic Lateral Sclerosis Research
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Bone health and treatments
University of Genoa
2016-2025
Ospedale Policlinico San Martino
2016-2025
Ospedale Sacro Cuore Don Calabria
2025
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2024
Université de Limoges
2022
Inserm
2022
Institut de Recherche pour le Développement
2022
Azienda Sanitaria Unità Locale di Reggio Emilia
2022
University of Bologna
2022
TH Bingen University of Applied Sciences
2022
BACKGROUND: The extent of myocardial bone tracer uptake with technetium pyrophosphate, hydroxymethylene diphosphonate, and 3,3-diphosphono-1,2-propanodicarboxylate in transthyretin amyloid cardiomyopathy (ATTR-CM) might reflect cardiac burden be associated outcome. METHODS: Consecutive patients ATTR-CM who underwent diagnostic scintigraphy acquisition whole-body planar single-photon emission computed tomography (SPECT) images from the National Amyloidosis Centre 4 Italian centers were...
Decades of steady improvements in life expectancy Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes risk factors and cause-specific death rates different European countries related those during pandemic. used data methods Global Burden Diseases, Injuries, Risk Factors Study 2021 compare at birth, causes death, population exposure 16 Economic Area (Austria, Belgium, Denmark, Finland, France, Germany,...
This is an international multicentre study aimed at evaluating the combined value of dopaminergic neuroimaging and clinical features in predicting future phenoconversion idiopathic REM sleep behaviour (iRBD) subjects to overt synucleinopathy. Nine centres sent 123I-FP-CIT-SPECT data 344 iRBD patients 256 controls for centralized analysis. images were semiquantified using DaTQUANTTM, obtaining putamen caudate specific non-displaceable binding ratios (SBRs). The following variables also...
Metastasis-directed therapy (MDT) has been tested in clinical trials as a treatment option for oligorecurrent prostate cancer (PCa). However, there is an ongoing debate regarding the impact of using different imaging techniques interchangeably defining lesions and guiding MDT within trials. <b>Methods:</b> We retrospectively identified PCa patients who had 5 or fewer nodal, bone, visceral metastases detected by choline prostate-specific membrane antigen (PSMA) PET/CT underwent stereotactic...
Abstract Purpose We hypothesised that applying radiomics to [ 18 F]PSMA-1007 PET/CT images could help distinguish Unspecific Bone Uptakes (UBUs) from bone metastases in prostate cancer (PCa) patients. compared the performance of radiomic features human visual interpretation. Materials and methods retrospectively analysed 102 hormone-sensitive PCa patients who underwent exhibited at least one focal uptake with known clinical follow-up (reference standard). Using matRadiomics, we extracted PET...
Several studies have highlighted the role of vascular (18)F-NaF uptake as a marker ongoing calcium deposition. However, accumulation is often inconsistent with localization arterial plaque. Calcification activity and thus might prevail in earlier plaque stages. To test this hypothesis, we evaluated 3 different densities, using density calcification progression. We also tested whether attenuation-weighted image reconstruction affects stages.Sixty-four oncologic patients (14 men 50 women; mean...
The present translational study aimed to verify whether serial 18F-FDG PET/CT predicts doxorubicin cardiotoxicity. Methods: Fifteen athymic mice were treated intravenously with saline (n = 5) or 5 7.5 mg of per kilogram each) and underwent dynamic small-animal PET beforehand afterward estimate left ventricular (LV) metabolic rate glucose (MRGlu). Thereafter, we retrospectively identified 69 patients who had been successfully a regimen doxorubicin, bleomycin, vinblastine, dacarbazine for...
The purpose of this study is to develop and validate a 3D deep learning model that predicts the final clinical diagnosis Alzheimer's disease (AD), dementia with Lewy bodies (DLB), mild cognitive impairment due (MCI-AD), cognitively normal (CN) using fluorine 18 fluorodeoxyglucose PET (18F-FDG PET) compare model's performance multiple expert nuclear medicine physicians' readers.Retrospective 18F-FDG scans for AD, MCI-AD, CN were collected from neuroimaging initiative (556 patients 2005 2020),...
We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [18F]-FDG PET, including a dedicated acquisition at our institution between May and December 2020 following their recovery SARS-Cov2 Fourteen these presented hyposmia (smell diskettes olfaction test was used). A voxel-wise analysis (using Statistical Parametric Mapping software version 8 (SPM8)) performed identify regions...
In the last years, theranostics has expanded therapeutic options available for prostate cancer patients. this review, we explore dynamic field and its potential to revolutionize precision medicine cancer. We delve into foundational principles, clinical applications, emerging opportunities, emphasizing synergy between radioligand therapy other systemic treatments. Additionally, address ongoing challenges, including optimizing patient selection, assessing treatment responses, determining role...
Unspecific bone uptake (UBU) related to [
Doxorubicin (DOX)-based chemotherapy for Hodgkin lymphoma (HL) yields excellent disease-free survival, but poses a substantial risk of subsequent left ventricular (LV) dysfunction and heart failure, typically with delayed onset. At the cellular level, this cardiotoxicity includes deranged cardiac glucose metabolism. By reviewing hospital records from January 2008 through December 2016, we selected HL patients meeting following criteria: ≥ 18 year-old; first-line DOX-containing chemotherapy;...
To identify brain regions whose metabolic impairment contributes to dementia with Lewy bodies (DLB) clinical core features expression and assess the influence of severity global cognitive on DLB hypometabolic pattern.Brain fluorodeoxyglucose positron emission tomography information were available in 171 patients belonging imaging repository European Consortium. Principal component analysis was applied relevant local data variance. A linear regression model generate core-feature-specific...