A5038509881- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Health, Environment, Cognitive Aging
- Genetic Neurodegenerative Diseases
- Prostate Cancer Treatment and Research
- Frailty in Older Adults
- Neurological and metabolic disorders
- Neural dynamics and brain function
University Hospital of Geneva
2016-2025
University of Geneva
2016-2025
Centre d'Imagerie BioMedicale
2022-2025
École Polytechnique Fédérale de Lausanne
2025
Geneva College
2012-2024
University of Trento
2024
Forschungszentrum Jülich
2010-2024
University Hospital Cologne
2024
University of Cologne
2008-2024
University of Brescia
2008-2024
Primary progressive aphasia (PPA) is characterized by isolated decline in language functions. Semantic dementia and nonfluent are accepted PPA variants. A "logopenic" variant (LPA) has also been proposed, but its cognitive anatomic profile less defined. The aim of this study was to establish the features LPA.Six previously unreported LPA cases underwent extensive neuropsychological evaluation an experimental phonological loop functions, including auditory visual span tasks with digits,...
Diagnostic accuracy in FDG-PET imaging highly depends on the operating procedures. In this clinical study dementia, we compared diagnostic at a single-subject level of a) Clinical Scenarios, b) Standard FDG Images and c) Statistical Parametrical (SPM) Maps generated via new optimized SPM procedure. We evaluated added value FDG-PET, either or Maps, to Scenarios. 88 patients with neurodegenerative diseases (Alzheimer's Disease—AD, Frontotemporal Lobar Degeneration—FTLD, Dementia Lewy...
Abstract Purpose This joint practice guideline or procedure standard was developed collaboratively by the European Association of Nuclear Medicine (EANM) and Society Molecular Imaging (SNMMI). The goal this is to assist nuclear medicine practitioners in recommending, performing, interpreting, reporting results dopaminergic imaging parkinsonian syndromes. Methods Currently investigations can assess both presynaptic postsynaptic function synapses. To date EANM SNMMI have published procedural...
The present procedural guidelines summarize the current views of EANM Neuro-Imaging Committee (NIC). purpose these is to assist nuclear medicine practitioners in making recommendations, performing, interpreting, and reporting results [18F]FDG-PET imaging brain. aim help achieve a high-quality standard [18F]FDG brain further increase diagnostic impact this technique neurological, neurosurgical, psychiatric practice. document replaces former version that have been published 2009. These new...
The key Alzheimer's disease (AD) biomarkers are traditionally measured with techniques/exams that either expensive (amyloid-positron emission tomography (PET) and tau-PET), invasive (cerebrospinal fluid Aβ42 p-tau181), or poorly specific (atrophy on MRI hypometabolism fluorodeoxyglucose-PET). Recently developed plasma could significantly enhance the efficiency of diagnostic pathway in memory clinics improve patient care. This study aimed to: (1) confirm correlations between traditional AD...
Abstract Background and objective Phosphorylated tau ( p -tau) 217 has recently received attention because it seems more reliable than other -tau variants for identifying Alzheimer’s disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma CSF -tau217 with -tau181 -tau231 in a memory clinic cohort. Methods The study included 114 participants (CU = 33; MCI 67; Dementia 14). were correlated versus continuous measures amyloid (A) (T)-PET. phospho-epitopes assessed...
Previous reports have shown that higher education is associated with more severe brain pathology in patients Alzheimer disease (AD), suggesting these individuals a functional reserve provided by education, which masks the clinical expression of degree neurodegeneration. It unknown if similar mechanism exists amnestic mild cognitive impairment (aMCI). The aim this study was to assess impact and occupation on glucose metabolism (rCMRglc) measured FDG-PET aMCI very large sample subjects...
Amyloid PET tracers have been developed for in vivo detection of brain fibrillar amyloid deposition Alzheimer's disease (AD). To serve as an early biomarker AD the need to be analysed multicentre clinical studies.In this study 238 [(11)C]Pittsburgh compound-B (PIB) datasets from five different European centres were pooled. Of these datasets, 18 excluded, leaving [(11)C]PIB 97 patients with clinically diagnosed (mean age 69 ± 8 years), 72 mild cognitive impairment (MCI; mean 67.5 years) and...
A progressive loss of dopamine neurons in the substantia nigra (SN) is considered main feature idiopathic Parkinson's disease (PD). Recent neuropathological evidence however suggests that axons nigrostriatal dopaminergic system are earliest target α-synuclein accumulation PD, thus principal site for vulnerability. Whether this applies to vivo and also mesolimbic has not been investigated yet. We used [11C]FeCIT PET measure presynaptic transporter (DAT) activity both systems, 36 early PD...
<h3>BACKGROUND AND PURPOSE:</h3> Brain MR imaging is routinely performed in the work-up of suspected PD, yet its role essentially limited to exclusion other pathologies. We a pattern-recognition analysis based on DTI data detect subjects with PD at individual level. <h3>MATERIALS METHODS:</h3> included 40 consecutive patients Parkinsonism suggestive who had 3T, brain <sup>123</sup>I ioflupane SPECT (DaTSCAN), and extensive neurologic testing including follow-up (17 PD: age range, 67.8 ± 6.7...
Abstract Cognitive reserve (CR) and brain (BR) are protective factors against age‐associated cognitive decline neurodegenerative disorders. Very limited evidence exists about gender effects on aging the effect of CR modulation in healthy Alzheimer's Dementia (AD). We investigated differences metabolic activity resting‐state network connectivity, as measured by 18 F‐FDG‐PET, AD, also considering education occupation. The clinical imaging data were retrieved from large datasets elderly...
Our purpose was to assess the performance of full-dose (FD) PET image synthesis in both and sinogram space from low-dose (LD) images sinograms without sacrificing diagnostic quality using deep learning techniques. Methods: Clinical brain PET/CT studies 140 patients were retrospectively used for LD-to-FD conversion. Five percent events randomly selected FD list-mode data simulate a realistic LD acquisition. A modified 3-dimensional U-Net model implemented predict projection (PSS) (PIS) their...