A5087294774- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Medical Imaging Techniques and Applications
- Neurological Disorders and Treatments
- Neurobiology of Language and Bilingualism
- Aging and Gerontology Research
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Technology Use by Older Adults
- Nicotinic Acetylcholine Receptors Study
- Health, Environment, Cognitive Aging
- Cancer-related cognitive impairment studies
- Computational Drug Discovery Methods
- Olfactory and Sensory Function Studies
- Older Adults Driving Studies
- Hearing Loss and Rehabilitation
- Cerebrovascular and genetic disorders
- Health disparities and outcomes
- Cerebrovascular and Carotid Artery Diseases
- Language Development and Disorders
- Tryptophan and brain disorders
Karolinska University Hospital
2014-2024
Karolinska Institutet
2015-2024
Stockholm University
2014-2024
Centro de Investigación Biomédica en Red
2020
Hospital de Sant Pau
2020
Biomedical Research Networking Center on Neurodegenerative Diseases
2020
Biomedical Research Institute
2020
Universitat Autònoma de Barcelona
2020
Wellcome Centre for Human Neuroimaging
2020
King's College London
2020
Beta amyloid is one of the major histopathological hallmarks Alzheimer's disease. We recently reported in vivo imaging 16 Alzheimer patients, using PET ligand N-methyl[11C]2-(4'-methylaminophenyl)-6-hydroxy-benzothiazole (PIB). In present study we rescanned these patients after 2.0 +/- 0.5 years and have described interval change deposition regional cerebral metabolic rate for glucose (rCMRGlc) at follow-up. Sixteen with disease were re-examined by means PET, PIB...
Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD) brain tissue. It is therefore of great interest to develop a PET tracer for visualizing astrocytes vivo, enabling the study regional distribution both and Aβ. A multitracer investigation was conducted patients mild cognitive impairment (MCI), AD, healthy controls using <sup>11</sup>C-deuterium-L-deprenyl (<sup>11</sup>C-DED) measure monoamine oxidase B located astrocytes. Along <sup>11</sup>C-DED...
See Schott and Fox (doi: 10.1093/brain/awv405 ) for a scientific commentary on this article. Alzheimer's disease is multifactorial dementia disorder characterized by early amyloid-β, tau deposition, glial activation neurodegeneration, where the interrelationships between different pathophysiological events are not yet well characterized. In study, longitudinal multitracer positron emission tomography imaging of individuals with autosomal dominant or sporadic was used to quantify changes in...
Background and Purpose— To provide further insight into the MRI assessment of age-related white matter changes (ARWMCs) with visual rating scales, 3 raters different levels experience tested interrater agreement comparability widely used scales in a cross-sectional follow-up setting. Furthermore, correlation between ratings quantitative volumetric measurement was assessed. Methods— Three from sites using established (Manolio, Fazekas Schmidt, Scheltens) evaluated 74 baseline scans 5 European...
The objective of this study was to assess whether reduced glucose metabolism (rCMRGlu) and cognitive functioning could predict development Alzheimer's disease (AD) in subjects with mild impairment (MCI). Twenty MCI patients underwent baseline follow-up investigations rCMRGlu, as measured by PET, function neuropsychological test assessments. Subjects were clinically followed up an average interval 36.5 months. Two groups obtained after the second clinical assessment. Nine diagnosed AD...
Recent research has identified a transitional state between the cognitive changes of normal aging and Alzheimer's disease (AD), known as mild impairment (MCI). MCI patients experience memory loss to greater extent than one would expect for age, yet they do not meet currently accepted criteria clinically probable AD. An issue under investigation is whether represents preclinical stages AD or distinct static aetiology. In an attempt address this issue, present investigations are adopting...
In this study the best combination of quantitative electroencephalographic variables (qEEG) for discrimination groups with mild to moderate Alzheimer''s disease (AD), cognitive impairment and healthy subjects was defined related neuropsychological performance. The population included 18 patients probable AD, 19 objective memory disturbances, 17 subjective complaints who did not have clinical evidence disturbance, 16 controls. AD had significantly increased theta decreased alpha relative...
Positron emission tomography was used to study regional cerebral blood flow (H2(15)O method) in groups of young and older adults during implicit explicit retrieval, following a procedure devised by Squire et al. (1992). At study, subjects were exposed four lists words. Following list presentation, presented with three-letter word stems under conditions: (1) silent viewing, (2) completion that could not form words from the list, instruction provide first came mind (baseline), (3) stems, half...
<b><i>Objective:</i></b> To examine patterns of brain activation during verbal episodic retrieval in normal elderly subjects and patients an early phase AD. <b><i>Background:</i></b> It is established that 1) a profound memory impairment cardinal symptom AD; 2) some the earliest changes this disease occur regions critical to memory, such as hippocampus neighboring regions. Yet, it remains largely unknown whether deficit seen AD paralleled by concomitant alterations activity actual task...
The relationship between quantitative measurements of brain white-matter hyperintensity (WMH), assessed by magnetic resonance imaging and neuropsychological functions, was explored in demented patients healthy aged individuals with without WMH 12 regions. prevalence significantly higher vascular dementia compared Alzheimer's disease, especially posterior periventricular Results showed no difference any measurement adults WMH. were more impaired tests visuoconstruction, attention,...
Amyloid PET tracers have been developed for in vivo detection of brain fibrillar amyloid deposition Alzheimer's disease (AD). To serve as an early biomarker AD the need to be analysed multicentre clinical studies.In this study 238 [(11)C]Pittsburgh compound-B (PIB) datasets from five different European centres were pooled. Of these datasets, 18 excluded, leaving [(11)C]PIB 97 patients with clinically diagnosed (mean age 69 ± 8 years), 72 mild cognitive impairment (MCI; mean 67.5 years) and...
<h3>Objective:</h3> To investigate the particular pathology of Arctic <i>APP</i> (<i>APP</i>arc) early-onset familial Alzheimer disease (eoFAD) mutation for first time in vivo with PET comparison other eoFAD mutations and sporadic (sAD). <h3>Methods:</h3> We examined 2 <i>APP</i>arc carriers together 5 noncarrier siblings cross-sectionally <sup>11</sup>C-labeled Pittsburgh compound B (PiB) <sup>18</sup>F-fluorodeoxyglucose (FDG) PET, as well MRI, CSF biomarkers, neuropsychological tests....
<i>Background/Aims:</i> Degeneration of cholinergic neurons in the basal forebrain correlates with cognitive decline patients Alzheimer’s disease (AD). Targeted delivery exogenous nerve growth factor (NGF) has emerged as a potential AD therapy due to its regenerative effects on animal models. Here we report results first-in-man study encapsulated cell (EC) biodelivery NGF primary objective explore safety and tolerability. <i>Methods:</i> This was an open-label,...
The accumulation of β-amyloid in the brain is an early event Alzheimer's disease. This study presents first patient with disease who underwent positron emission tomography imaging amyloid tracer, Pittsburgh Compound B to visualize fibrillar brain. Here we relate clinical progression, and functional molecular neuropathological alterations at autopsy gain new insight into relationship between accumulation, inflammatory processes cholinergic neurotransmitter system studies...
Abstract Studying autosomal dominant Alzheimer’s disease (ADAD), caused by gene mutations yielding nearly complete penetrance and a distinct age of symptom onset, allows investigation presymptomatic pathological processes that can identify therapeutic window for disease-modifying therapies. Astrocyte activation may occur in (AD) because reactive astrocytes surround β-amyloid (Aβ) plaques autopsy brain tissue. Positron emission tomography was performed to investigate fibrillar Aβ,...
Abstract Background Targeted delivery of nerve growth factor (NGF) has emerged as a potential therapy for Alzheimer’s disease (AD) due to its regenerative effects on basal forebrain cholinergic neurons. This hypothesis been tested in patients with AD using encapsulated cell biodelivery NGF (NGF-ECB) first-in-human study. We report our results from third-dose cohort receiving second-generation NGF-ECB implants improved secretion. Methods Four mild moderate were recruited participate an...
The aim of this study was to explore the cerebral distribution tau-specific PET tracer [18F]THK5317 (also known as (S)-[18F]THK5117) retention in different stages Alzheimer's disease; and any associations with markers hypometabolism amyloid-beta deposition. Thirty-three individuals were enrolled, including nine patients disease dementia, thirteen mild cognitive impairment (MCI), two non-Alzheimer's healthy controls (five young four elderly). In a multi-tracer design [18F]THK5317, [11C]...
The development of tau-specific positron emission tomography (PET) tracers allows imaging in vivo the regional load tau pathology Alzheimer's disease (AD) and other tauopathies. Eighteen patients with baseline investigations enroled a 17-month follow-up study, including 16 AD (10 had mild cognitive impairment positive amyloid PET scan, that is, prodromal AD, six dementia) two corticobasal syndrome. All underwent scans [18F]THK5317 (tau deposition) [18F]FDG (glucose metabolism) at follow-up,...
The present study examined whether cognitive variables measured at baseline could predict incident cases of Alzheimer's disease (AD) after a 3-year follow-up period. Twenty-six AD adults and 179 very old (M = 83.5 years) without dementia participated in population-based study. Cognitive performance was indexed by the Mini-Mental State Examination (MMSE) multiple indices memory visuospatial verbal performance. A logistic regression analysis that controlled for age, gender, education indicated...
<b><i><i>Objective:</i></i></b> To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD. <b><i>Methods:</i></b> Eleven mild AD received for 12 months. Cholinesterase (ChE) activities CSF plasma were assessed colorimetrically. Immunoblot analysis was used to evaluate AChE isoforms. Neuropsychiatric tests performed throughout study. <b><i>Results:</i></b> At months, mean dose 8.6 mg/d specific ChE lower...