A5038918680- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Spinal Dysraphism and Malformations
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cognitive Functions and Memory
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Cerebrospinal fluid and hydrocephalus
- Cancer-related cognitive impairment studies
- Sleep and related disorders
- Sleep and Wakefulness Research
- Nutritional Studies and Diet
- Frailty in Older Adults
- Neurological Disease Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Nutrition and Health in Aging
- Congenital Anomalies and Fetal Surgery
- Hormonal Regulation and Hypertension
- Health, psychology, and well-being
- Health and Well-being Studies
- Aging and Gerontology Research
- Schizophrenia research and treatment
Karolinska University Hospital
2008-2025
Karolinska Institutet
2016-2025
University of Gothenburg
2023
Amyloidosis Foundation
2023
Inflammation Research Foundation
2022
University of Eastern Finland
2022
Imperial College London
2022
Växjö Kommun
2014
Lund University
1971
Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits mild disease dementia. LipiDiDiet investigated effects on cognition and related measures prodromal Here, we report 24-month results trial.LipiDiDiet was a randomised, controlled, double-blind, parallel-group, multicentre trial (11 sites Finland, Germany, Netherlands, Sweden), with optional 12-month double-blind extensions. The enrolled individuals...
Abstract Background Combining multimodal lifestyle interventions and disease-modifying drugs (novel or repurposed) could provide novel precision approaches to prevent cognitive impairment. Metformin is a promising candidate in view of the well-established link between type 2 diabetes (T2D) Alzheimer’s Disease emerging evidence its potential neuro-protective effects (e.g. vascular, metabolic, anti-senescence). MET-FINGER aims test FINGER 2.0 intervention, combining an updated multidomain...
Abstract Background Amyloid and tau aggregates are considered to cause neurodegeneration consequently cognitive decline in individuals with Alzheimer’s disease (AD). Here, we explore the potential of cerebrospinal fluid (CSF) proteins reflect AD pathology decline, aiming identify biomarkers for monitoring outcomes disease-modifying therapies targeting these aggregates. Method We used a multiplex antibody-based suspension bead array measure levels 49 CSF from Swedish GEDOC memory clinic...
Rapamycin is an inhibitor of the mechanistic target rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it a promising candidate for general gero- neuroprotective treatment in humans. Results from mouse models Alzheimer's disease have shown beneficial effects rapamycin, including preventing or reversing cognitive deficits, reducing amyloid oligomers tauopathies normalizing synaptic plasticity cerebral glucose uptake. The "Evaluating Treatment Disease using Positron...
Abstract Objective The effects of (−)‐phenserine (phenserine) and placebo/donepezil treatment on regional cerebral metabolic rate for glucose (rCMRglc) brain amyloid load were investigated by positron emission tomography in 20 patients with mild Alzheimer's disease relation to cerebrospinal fluid (CSF) plasma biomarkers, cognitive function. Methods first 3 months the study was a randomized, double‐blind, placebo‐controlled phase, during which 10 received phenserine (30mg/day) placebo. Three...
To investigate the associations between midlife work-related stress and mild cognitive impairment (MCI), dementia, Alzheimer's disease later in life, a large representative population.Cardiovascular Risk Factors, Aging Dementia (CAIDE) study participants were randomly selected from independent population-based surveys (mean age 50 years). A random sample of 2,000 individuals was invited for two reexaminations including tests (at mean 71 78), 1,511 subjects participated at least one...
<h3>Background and Objectives</h3> ATN (β-amyloid [Aβ], tau, neurodegeneration) system categorizes individuals based on their core Alzheimer disease (AD) biomarkers. An important potential future use for is therapeutic decision-making in clinical practice once disease-modifying treatments (e.g., anti-amyloid), become widely available. In this cross-sectional study, we applied estimated eligibility anti-amyloid treatment a real-life memory clinic with biomarker assessments integrated into the...
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. LipiDiDiet trial highlighted of medical food prodromal Alzheimer's disease (AD). However, the feasibility impact multimodal interventions combining with AD is unclear. MIND-ADmini was 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled (RCT). Participants were...
(1971). Experimental Pulpotomy in Human Bicuspids with Reference to Cutting Technique. Acta Odontologica Scandinavica: Vol. 29, No. 2, pp. 155-163.
Allostatic load (AL) is defined as the cumulative dysregulation of neuroendocrine, immunological, metabolic, and cardiovascular systems that increases susceptibility to stress-related health problems. Several dementia Alzheimer's disease (AD) risk factors have been identified, yet little known about role AL its associations with AD biomarkers (e.g., beta-amyloid (Aβ) or tau) cognitive function among memory clinic patients. Hence, this study aims assess association between biomarkers,...
Abstract Objective To describe health issues and living conditions in a cohort of adults with Spina bifida. Material methods A cross‐sectional study was conducted by multidisciplinary team. Adults spina bifida ( n = 219) were invited to participate. One‐hundred‐and‐ninety‐six persons (104 women 92 men; 18–73 years, median age 33 years) included. Structured interviews, questionnaires, clinical assessments for medical, social, physical, cognitive functions used. Results There large variation...
Many patients presenting to a memory disorders clinic for subjective complaints do not show objective evidence of decline on neuropsychological data, have nonpathological biomarkers Alzheimer's disease, and develop neurodegenerative disorder. Lifestyle variables, including sleep problems stress, are factors known affect cognition. Little is about how these contribute patients' sense decline. Understanding lifestyle associated with the failing that causes seek formal evaluation important both...
Abstract Background Determination of β-amyloid (Aβ) positivity and likelihood underlying Alzheimer’s disease (AD) relies on dichotomous biomarker cut-off values. Individuals with mild cognitive impairment (MCI) Aβ within the normal range may still have a substantial risk developing dementia, primarily Alzheimer type. Their prognosis, as well predictors clinical progression, are not fully understood. The aim this study was to explore associations cerebrospinal fluid (CSF) biomarkers (Aβ42,...
Alzheimer's disease and related dementias have a multifactorial aetiology heterogeneous biology. The current study aims to identify different biological signatures in deeply phenotyped memory clinic patient population. In this cross-sectional study, we analysed 49 pre-specified proteins using multiplex antibody-based suspension bead array 278 CSF samples from the real-world research database biobank at Karolinska University Hospital Memory Clinic, Solna, Sweden. Patients with clinical...
Background: Interventions simultaneously targeting multiple risk factors and mechanisms are most likely to be effective in preventing cognitive impairment. This was indicated the Finnish Geriatric Intervention Study Prevent Cognitive Impairment Disability (FINGER) testing a multidomain lifestyle intervention among at-risk individuals. The importance of medical food at early symptomatic disease stage, prodromal Alzheimer’s (AD), emphasized LipiDiDiet trial. feasibility effects multimodal...
Objective This study aims to investigate the relationship between diurnal cortisol patterns, cognition and Alzheimer’s disease (AD) biomarkers in memory clinic patients. Method Memory patients were recruited from Karolinska University Hospital Sweden (n=155). Diurnal patterns assessed using five measures: awakening levels, response, bedtime ratio of levels (AM/PM ratio) total daily output. Cognition was measured domains: memory, working processing speed, perceptual reasoning overall...
Previous findings demonstrated an altered pattern of amyloid-β protein precursor (AβPP) expression in platelets Alzheimer's disease (AD) patients compared with either healthy control subjects or non-Alzheimer-type dementia. In att
<b><i>Background/Aims:</i></b> A large proportion of patients at memory disorders clinics are classified as having subjective cognitive impairment (SCI). Previous research has investigated whether particular lifestyle factors known to affect cognition can be useful in differentiating who do not show objective evidence decline. There may also exist subgroups with respect that could help clinicians understand the patient group presents clinics. These differ diagnostic...
Non-invasive automatic screening for Alzheimer’s disease has the potential to improve diagnostic accuracy while lowering healthcare costs. Previous research shown that patterns in speech, language, gaze, and drawing can help detect early signs of cognitive decline. In this paper, we describe a highly multimodal system unobtrusively capturing data during real clinical interviews conducted as part assessments disease. The uses nine different sensor devices (smartphones, tablet, an eye tracker,...
This is the study plan of Karolinska NeuroCOVID study, a neurocognitive impairment after severe COVID-19, relating post-intensive care unit (ICU) cognitive and neurological deficits to biofluid markers MRI. The COVID-19 pandemic has posed enormous health challenges individuals health-care systems worldwide. An emerging feature that temporary extended impairment, exhibiting myriad symptoms signs. causes this symptomatology have not yet been fully elucidated.In we aim investigate patients...
Background: Due to an ageing demographic and rapid increase of cognitive impairment dementia, combined with potential disease-modifying drugs other interventions in the pipeline, there is a need for development accurate, accessible efficient screening instruments, focused on early-stage detection neurodegenerative disorders. Objective: In this proof concept report, we examine validity newly developed digital test, Geras Solutions Cognitive Test (GCST) compare its accuracy against Montreal...
Background: Sarcopenia and cognitive impairment are two leading causes of disabilities. Objective: The objective was to examine the prevalence sarcopenia investigate association between diagnostic components (muscle strength, muscle mass, physical performance) in memory clinic patients. Methods: 368 patients were included (age 59.0±7.25 years, women: 58.7%), displaying three clinical phenotypes impairments, i.e., subjective (SCI, 57%), mild (MCI, 26%), Alzheimer’s disease (AD, 17%). defined...