A5056080569- Congenital gastrointestinal and neural anomalies
- Intestinal Malrotation and Obstruction Disorders
- Congenital Anomalies and Fetal Surgery
- Intensive Care Unit Cognitive Disorders
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Bowel Disease
- Urological Disorders and Treatments
- Gastrointestinal disorders and treatments
- Pelvic floor disorders treatments
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Hernia repair and management
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Child Nutrition and Feeding Issues
- Congenital Diaphragmatic Hernia Studies
- Gastroesophageal reflux and treatments
- Intestinal and Peritoneal Adhesions
- Anesthesia and Sedative Agents
- Ultrasound in Clinical Applications
- Heart Rate Variability and Autonomic Control
- Spinal Cord Injury Research
- Multiple Sclerosis Research Studies
Karolinska Institutet
2016-2025
ERN GUARD-Heart
2025
ERNICA
2025
Karolinska University Hospital
2015-2024
Glanrhyd Hospital
2024
Danderyds sjukhus
2020-2024
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Development of potentially life-threatening enterocolitis is the most frequent complication in children with Hirschsprung disease (HSCR), even after definitive corrective surgery. Intestinal microbiota likely contribute to etiology enterocolitis, so aim this study was compare fecal bacterial and fungal communities who developed Hirschsprung-associated (HAEC) HSCR patients had never enterocolitis. Eighteen completed surgery were enrolled: 9 a history HAEC did not. Fecal DNA isolated 16S ITS-1...
Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation cognitive decline. Although preclinical studies have in part described this systemic-to-brain signaling pathway, we lack information on how these changes appear humans. This study examines short- long-term impact of abdominal surgery human system by positron emission tomography (PET) relation to blood reactivity, plasma biomarkers, function.Eight males undergoing prostatectomy under...
Background Hirschsprung disease is a congenital intestinal motility disorder characterized by an absence of enteric ganglion cells. Total colonic aganglionosis and near total or aganglionosis, defined as cells in the entire colon with variable length small bowel involved, are life-threatening conditions which affect less than 10 % all patients disease. The aim this project was to develop clinical consensus statements within ERNICA, European Reference Network for rare digestive diseases, on...
Long-term cognitive decline is an adverse outcome after major surgery associated with increased risk for mortality and morbidity. We studied the cerebrospinal fluid (CSF) serum biochemical inflammatory response to a standardized orthopedic surgical procedure possible association long-term changes in function. hypothesized that CSF pattern would differ patients having defined as composite z score of ≥1.0 compared without at 3 months postsurgery.Serum biomarkers inflammation blood-brain...
BACKGROUND AND OBJECTIVES: Hirschsprung disease (HSCR) is a congenital defect of the enteric nervous system characterized by lack ganglion cells in distal hindgut. The aim this study was to assess birth prevalence, perinatal characteristics, and maternal risk factors HSCR patients Sweden. METHODS: This nationwide, population-based, case-control all children born Sweden between 1982 2012 registered Swedish Medical Birth Register. Cases were identified National Patient Register data on...
The increase in prenatal diagnosis together with the high rates of associated anomalies omphalocele has led to increased termination pregnancies. aim this study was examine national Swedish birth prevalence and survival among these patients.This is based on a nationwide population-based cohort all children born Sweden between 1/1/1997 31/12/2016. All cases were identified though National Patient Register Medical Birth Register. Outcome malformations deaths retrieved from Defects Causes Death...
BackgroundControlled outcomes into adulthood for females with anorectal malformation (ARM) are still scantily studied. The primary aim was to investigate bowel function, bladder function and health-related quality of life (HRQoL) in operated ARM.MethodsA cross-sectional questionnaire-based observational study performed including treated ARM at our institution between 1994 2017. assessed score (BFS) urinary tract lower symptoms (LUTS) questionnaires. HRQoL investigated validated age-dependent...
Postoperative neurocognitive decline is a frequent complication in adult patients undergoing major surgery with increased risk for morbidity and mortality. The mechanisms behind cognitive after anaesthesia are not known. We studied the association between CSF blood biomarkers of neuronal injury or brain amyloidosis long-term changes function.In orthopaedic (knee hip replacement), samples were obtained before then at 4, 8, 24, 32, 48 h skin incision through an indwelling spinal catheter....
ABSTRACT Aim This study aimed to develop a universally applicable core set of quality indicators for Hirschsprung's disease care through consensus‐driven process, standardise and improve across Europe. Methods A modified Delphi method was used achieve consensus among healthcare professionals (HPs) patient representatives (PRs) Participants completed three rounds anonymous surveys, rating care. systematic literature review informed the initial item list. Results were analysed using predefined...
<p dir="ltr">Early and accurate prioritization of trauma patients, known as triage, is crucial to identify those in need emergency life-saving interventions. Excellent care relies strongly on correct which impacts patients' experiences outcomes. Undertriage has been shown be associated with an elevated risk undetected injuries missed However, the definition severe still debatable. This thesis aimed study aspects consequences in-hospital examine over-and undertriage, processes,...
Abstract Introduction The objective of this study is to determine short-term complications and evaluate long-term bowel function, lower urinary tract symptoms, quality life (QoL) in patients treated for Hirschsprung's disease (HSCR) with transanal endorectal pull-though (TERPT) compared healthy controls. Materials Methods This cross-sectional case–control included 30 HSCR TERPT 2006 2014 at Karolinska University Hospital, controls matched age gender. Data on were compiled from medical...
Background In addition to facilitating lipid digestions, bile acids (BA) are signalling molecules acting on receptors immune cells and along the gastrointestinal (GI) tract. The aim of this study was assess if altered acid profiles in plasma associated with Crohn's disease (CD).
Hirschsprung disease (HSCR) has previously been associated with inflammatory bowel (IBD). There are no data to show how common this association is. The aim of the present study was assess risk IBD in individuals HSCR a population-based cohort.This nationwide, cohort study. exposure and outcome IBD. included all registered Swedish National Patient Register between 1964 2013 10 age- sex-matched controls per patient, randomly selected from Population Register. Individuals were identified Data...
Hirschsprung disease (HSCR) has previously been associated with increased mortality. The aim of this study was to assess mortality in patients a population-based cohort.This nationwide, cohort study. exposure HSCR and the outcome death. included all individuals registered Swedish National Patient Register between 1964 2013 ten age- sex-matched controls per patient, randomly selected from Population Register. Mortality cause death were assessed using Causes Death Register.The comprised 739...
Hirschsprung's disease (HSCR) is a developmental defect of the enteric nervous system. Transanal endorectal pullthrough (TERPT) one surgical procedures for HSCR. Clavien-Dindo an objective classification system, used worldwide, to describe postoperative complications. The aim this study was use grading short-term complication after TERPT.This cohort including all 69 individuals, with biopsy-verified HSCR, managed TERPT at our institution between 2006 and 2018. Data on procedure, as well...