A5070660153- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Cerebral Palsy and Movement Disorders
- Advanced Neuroimaging Techniques and Applications
- Balance, Gait, and Falls Prevention
- Genetic Neurodegenerative Diseases
- Parkinson's Disease and Spinal Disorders
- Autoimmune Neurological Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Neurological diseases and metabolism
- Action Observation and Synchronization
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Amyotrophic Lateral Sclerosis Research
- Advanced MRI Techniques and Applications
- Motor Control and Adaptation
- Dementia and Cognitive Impairment Research
- Neuroscience and Neural Engineering
- Cardiovascular Health and Disease Prevention
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2002-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2025
Vita-Salute San Raffaele University
2013-2025
San Raffaele University of Rome
2001-2023
University of Catania
2023
University of Pavia
2021
IRCCS Ospedale San Raffaele
1995-2019
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2014-2017
Toronto Western Hospital
2015
University of Messina
2015
Abstract Objective To use a multimodal approach to assess brain structural pathways and resting state (RS) functional connectivity abnormalities in patients with Parkinson's disease freezing of gait (PD‐FoG). Methods T1‐weighted, diffusion tensor (DT) MRI RS (fMRI) were obtained from 22 PD‐FoG 35 controls on 3.0 T MR scanner. Patients underwent clinical, motor, neuropsychological evaluations. Gray matter (GM) volumes white (WM) damage assessed using voxel based morphometry tract‐based...
A progressive loss of dopamine neurons in the substantia nigra (SN) is considered main feature idiopathic Parkinson's disease (PD). Recent neuropathological evidence however suggests that axons nigrostriatal dopaminergic system are earliest target α-synuclein accumulation PD, thus principal site for vulnerability. Whether this applies to vivo and also mesolimbic has not been investigated yet. We used [11C]FeCIT PET measure presynaptic transporter (DAT) activity both systems, 36 early PD...
ABSTRACT Background Action observation training and motor imagery may improve learning in Parkinson's disease (PD). Objectives The objectives of this study were to assess mobility balance (performing dual tasks) brain functional reorganization following 6 weeks action associated with dual‐task gait/balance exercises PD patients postural instability gait disorders relative alone. Methods Twenty‐five PD–postural disorder randomized into 2 groups: the DUAL‐TASK+AOT‐MI group performed a 6‐week...
To estimate the prevalence of Pisa syndrome (PS) in patients with Parkinson disease (PD) and to assess association between PS demographic clinical variables.In this multicenter cross-sectional study, consecutive outpatients PD attending 21 movement disorders Italian tertiary centers were enrolled underwent standardized evaluation. was defined as trunk lateral deviation ≥10°. Patients compared according presence for several variables.Among 1,631 PD, detected 143 (8.8%, 95% confidence interval...
Abstract Background and purpose This study was undertaken to determine the diagnostic prognostic value of a panel serum biomarkers correlate their concentrations with several clinical parameters in large cohort patients amyotrophic lateral sclerosis (ALS). Methods One hundred forty‐three consecutive ALS control consisting 70 other neurodegenerative disorders (DEG), mimic (ALSmd), 45 healthy controls (HC) were included. Serum neurofilament light chain (NfL), ubiquitin carboxyl‐terminal...
Abstract Objective . To identify overlapping and unique grey (GM) white matter (WM) signatures within the frontotemporal lobar degeneration (FTLD) continuum, discriminate likely FTLD‐TAU FTLD‐TDP patients using structural diffusion tensor (DT) magnetic resonance imaging (MRI). Methods T1‐weighted DT MRI were collected from 121 subjects: 35 motor neuron disease (MND), 14 behavioral variant of dementia, 12 semantic 11 nonfluent primary progressive aphasia, 21 supranuclear palsy syndrome...
Background and purpose Atypical Parkinsonian disorders ( APD ) frequently overlap in clinical presentations, making the differential diagnosis challenging early stages. The present study aimed to evaluate accuracy of [ 18 F]fluoro‐deoxy‐glucose positron emission tomography Statistical Parametric Mapping SPM optimized procedure supporting . Methods Seventy patients with possible were retrospectively included from a large cohort. underwent within 3 months first assessment diagnostic follow‐up....
Abstract Focal task‐specific tremors besides primary writing tremor have rarely been reported in the literature. We describe inne cases of focal induced by different specific tasks, involving a repetitive and frequently performed movement. Only one these patients had family history any similar disorders. There was no overt dystonia cases, but may be forms dystonia, rather than manifestation essential tremor.
Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays role iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported Parkinson's disease (PD) contributing to the pathological accumulation. We previously showed that ceruloplasmin is modified by oxidation vivo, and, addition, vitro deamidation of specific NGR-motifs foster gain integrin-binding function. Here we investigated whether loss CSF PD patients accompanied and function.We...
The event-related desynchronization (ERD) to voluntary movement is an indicator of cortical activation with a high time resolution and specific spatial representation. We have evaluated 10 patients affected by Parkinson's disease (PD), free from L-dopa treatment for at least 12 hours, control subjects. Each subject underwent ERD examination during self-paced (SPM) contingent negative variation (CNV) paradigms. was measured as the percentage decrease alpha band power calculated frequency...
Background: Pilot open-label application of high-frequency repetitive transcranial magnetic stimulation (rTMS) with H-coil in Parkinson's Disease (PD) have shown promising results. Objective: To evaluate safety and efficacy rTMS PD a double-blind, placebo-controlled, randomized study. Methods: Sixty patients were into 3 groups: M1-PFC (real on primary motor-M1 pre-frontal cortices-PFC), M1 M1, sham PFC), Sham (apparent stimulation). Primary outcome was baseline-normalized percent improvement...
In a previous transcranial Doppler (TCD) study, we demonstrated decrease in blood flow velocity the proximal tract of middle cerebral artery (MCA) patients with Alzheimer’s disease (AD). these there was also an asymmetry which positively correlated cognitive often seen early phase AD. this study found correlation between absolute values and indexes MCA adjusted metabolic relative cortical frontotemporoparietal (FTP) areas, evaluated by FDG-PET, neuropsychological indexes. Patients prevalent...