A5034527878- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Botulinum Toxin and Related Neurological Disorders
- Cerebral Palsy and Movement Disorders
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Muscle activation and electromyography studies
- Neurological diseases and metabolism
- Acute Ischemic Stroke Management
- Herpesvirus Infections and Treatments
- Voice and Speech Disorders
- Multiple Sclerosis Research Studies
- Fetal and Pediatric Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Transcranial Magnetic Stimulation Studies
- Cerebrovascular and Carotid Artery Diseases
- Neurological and metabolic disorders
- Health, Environment, Cognitive Aging
- Balance, Gait, and Falls Prevention
- Peripheral Artery Disease Management
Vita-Salute San Raffaele University
2013-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2025
IRCCS Ospedale San Raffaele
2019
Neuroscience Institute
2014-2018
San Raffaele University of Rome
2010-2016
University of Belgrade
2010-2016
Cognitive Neuroimaging Lab
2013-2015
University of Basel
2013
University Memory and Aging Center
2011-2012
Primary progressive aphasia is a clinical syndrome that encompasses three major phenotypes: non-fluent/agrammatic, semantic and logopenic. These entities have been associated with characteristic patterns of focal grey matter atrophy in left posterior frontoinsular, anterior temporal temporoparietal regions, respectively. Recently, network-level dysfunction has hypothesized but research to date focused largely on studying damage. The aim this study was assess the integrity white tracts...
<b>Objective:</b> To investigate, using MRI and voxel-based morphometry (VBM), whether specific patterns of gray matter (GM) white (WM) loss are associated with depression in patients Parkinson disease (PD). <b>Methods:</b> Forty PD 26 healthy subjects were studied. Patients diagnosed <i>DSM-IV</i> criteria. The Hamilton Depression Rating Scale (HDRS) was administered to patients. topographic distribution brain tissue controls assessed VBM as implemented Statistical Parametric Mapping...
In Assessment of OraL Laquinimod in PrEventing ProGRession Multiple SclerOsis (ALLEGRO), a phase III study relapsing-remitting multiple sclerosis (RRMS), oral laquinimod slowed disability and brain atrophy progression, suggesting may reduce tissue damage MS. MRI techniques sensitive to the most destructive aspects disease were used further investigate laquinimod's potential effects on inflammation neurodegeneration.1106 RRMS patients randomised 1:1 receive once-daily (0.6 mg) or placebo for...
Using diffusion tensor (DT) magnetic resonance imaging (MRI), damage to brain intrahemispheric and interhemispheric connections was assessed in 26 sporadic primary lateral sclerosis (PLS) patients compared with 28 amyotrophic (ALS) similar disability 35 healthy controls. DT MRI diagnostic accuracy distinguishing the two motor neuron disease (MND) variants tested. PLS ALS showed a distributed pattern of abnormalities system, including corticospinal tracts corpus callosum (CC). versus more...
Purpose To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) PD without MCI. Materials Methods This prospective study was approved by local ethics committees, written informed consent obtained from all subjects prior to enrollment. The individual of 170 (54 MCI, 116 MCI) 41 healthy control using deterministic diffusion-tensor tractography. A network-based statistic used assess connectivity differences among groups. Results...
The anterior temporal lobes (ATL) have been implicated in a range of cognitive functions including auditory and visual perception, language, semantic knowledge, social-emotional processing. However, the anatomical relationships between ATLs broader cortical networks that subserve these not fully elucidated. Using diffusion tensor imaging (DTI) probabilistic tractography, we tested hypothesis functional segregation information is reflected by distinct patterns structural connectivity to...
Abstract In this study, we wished to test, using magnetic resonance imaging and voxel‐based morphometry (VBM), whether specific cortical subcortical patterns of brain grey (GM) white matter (WM) tissue loss can be detected in patients with Richardson’s syndrome (PSP‐RS) progressive supranuclear palsy‐parkinsonism (PSP‐P), possibly account for their clinical heterogeneity. Twenty PSP, classified as PSP‐RS (10 patients) or PSP‐P patients), 24 healthy controls were studied. The Statistical...
Abstract Objective . To identify overlapping and unique grey (GM) white matter (WM) signatures within the frontotemporal lobar degeneration (FTLD) continuum, discriminate likely FTLD‐TAU FTLD‐TDP patients using structural diffusion tensor (DT) magnetic resonance imaging (MRI). Methods T1‐weighted DT MRI were collected from 121 subjects: 35 motor neuron disease (MND), 14 behavioral variant of dementia, 12 semantic 11 nonfluent primary progressive aphasia, 21 supranuclear palsy syndrome...
To test a multimodal magnetic resonance (MR) imaging-based approach composed of cortical thickness and white matter (WM) damage metrics to discriminate between variants primary progressive aphasia (PPA) that are nonfluent and/or agrammatic (NFVPPA) semantic (SVPPA).This study was approved by the local ethics committees on human studies, written informed consent from all patients obtained before their enrollment. T1-weighted diffusion-tensor (DT) MR images were 13 NFVPPA patients, SVPPA 23...
Non-cognitive features including personality changes are increasingly recognized in the three PPA variants (semantic-svPPA, non fluent-nfvPPA, and logopenic-lvPPA). However, differences emotion processing among its association with white matter tracts unknown. We compared detection across healthy controls (HC), related them to tract integrity cortical degeneration. Personality traits group were also examined relation tracts. Thirty-three patients svPPA, nfvPPA, lvPPA, 32 HC underwent...
This is a cross-sectional study aimed at investigating cognitive performances in patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic resonance imaging (MRI) to determine the topographical distribution of microstructural white matter (WM) damage or without deficits.DT MRI scans were obtained from 21 PLS 35 age- sex-matched healthy controls. All underwent comprehensive neuropsychological battery. Tract-based-spatial-statistics (TBSS) was used perform...
Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage.Using tractography, diffusion metrics were obtained from the superior and middle cerebellar peduncles major cerebral tracts 5 patients with progressive supranuclear palsy 13 controls.Patients showed severe intrinsic damage to peduncle, corpus callosum, cingulum bilaterally. Only decreased axial diffusivity was found left peduncle.Diffusion holds promise for providing accurate...
Thrombolysis is often withheld from acute ischemic stroke patients presenting with mild symptoms; however, up to 40% of these end a poor outcome when left untreated. Since there lack consensus on the definition minor symptoms, we aimed at addressing this issue by looking for features that would better predict functional outcomes 3 months.Among all admitted our Stroke Unit (n = 1,229), selected cohort who arrived within 24 hours symptoms onset, baseline NIHSS ≤6, not treated thrombolysis...