A5085479270- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Barrier Structure and Function Studies
- Anesthesia and Pain Management
- Neurobiology of Language and Bilingualism
- Nerve Injury and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Management of metastatic bone disease
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Cerebral Palsy and Movement Disorders
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Long-Term Effects of COVID-19
- Thermoregulation and physiological responses
- Cardiac Health and Mental Health
- Facial Nerve Paralysis Treatment and Research
- Herpesvirus Infections and Treatments
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Body Composition Measurement Techniques
Don Carlo Gnocchi Foundation
2021-2025
University of Florence
2019-2025
International Flame Research Foundation
2024
Azienda Ospedaliero-Universitaria Careggi
2016-2023
Vita-Salute San Raffaele University
2015
University of Turin
1984
In patients with acute ischemic stroke treated reperfusion therapy we aimed to evaluate whether pretreatment blood-brain barrier (BBB) leakage is associated subsequent hemorrhagic transformation (HT).We prospectively screened intravenous thrombolysis and/or endovascular treatment. Before treatment, each patient received computed tomography (CT), CT angiography, and perfusion. We assessed BBB within the area using volume transfer constant (Ktrans ) value. Our primary outcome was relevant HT,...
To test a multimodal magnetic resonance (MR) imaging-based approach composed of cortical thickness and white matter (WM) damage metrics to discriminate between variants primary progressive aphasia (PPA) that are nonfluent and/or agrammatic (NFVPPA) semantic (SVPPA).This study was approved by the local ethics committees on human studies, written informed consent from all patients obtained before their enrollment. T1-weighted diffusion-tensor (DT) MR images were 13 NFVPPA patients, SVPPA 23...
Ischemic stroke is a leading cause of disability and mortality, particularly among the elderly. Recanalization therapies, including thrombolysis thrombectomy, are essential for restoring blood flow saving ischemic tissue. However, these interventions may trigger reperfusion injury, worsening inflammation tissue damage, to blood-brain-barrier (BBB) disruption, cerebral edema (CE) adverse functional outcomes. Here we propose model integrating circulating inflammatory biomarkers with...
An accurate and reliable functional prognosis is vital to stroke patients addressing rehabilitation, their families, healthcare providers. This study aimed at developing validating externally patient-wise prognostic models of the global outcome discharge from intensive inpatient post-acute rehabilitation after stroke, based on a standardized comprehensive multidimensional assessment performed admission rehabilitation. Patients pathways within 30 days were prospectively enrolled in two...
Background Trunk control plays a crucial role in the stroke rehabilitation, but it is unclear which factors could influence trunk after an intensive rehabilitation treatment.Objectives To study demographic, clinical and functional variables predict recovery of post-stroke inpatient rehabilitation.Methods Subjects with acute, first-ever were enrolled data collected at admission discharge. The primary outcome was considered measured by Control Test (TCT). analyzed univariate multivariate...
High dose corticosteroid therapy is widely used as attack of inflammatory central nervous system disorders and can induce several adverse reactions. Bradycardia an infrequent event after corticosteroids administration often asymptomatic. We report a case woman admitted to the neurological department our hospital for paraesthesias lower limbs. She received adiagnosis myelitis high was prescribed. During she complained chest tightness, dyspnoea, weakness malaise. An electrocardiogram revealed...
Abstract Cerebral edema (CE) and hemorrhagic transformation (HT) are frequent unpredictable events in patients with acute ischemic stroke (AIS), even when an effective vessel recanalization has been achieved. These complications, related to blood-brain barrier (BBB) disruption, remain difficult prevent or treat may offset the beneficial effect of recanalization, lead poor outcomes. The aim this translational study is evaluate association circulating imaging biomarkers subsequent CE HT dual...
Stroke represents the second preventable cause of death after cardiovascular disease and third global disability. In countries where national registries clinical quality stroke care have been established, publication sharing collected data led to an improvement in survival patients. However, information on rehabilitation processes outcomes is often lacking, predictors functional remain poorly explored. This paper describes a multicenter study protocol implement Registry, mainly based...
Background: Acute ischemic stroke (AIS) represents one of the principal causes neurological morbidity and mortality worldwide. For a prompt efficient cerebral blood restoration, intravenous treatment with rt-PA is often combined mechanical thrombectomy (MT) which provides thrombi (CT) as study material, allowing investigation its cellular composition, morphological histopathological features. Indeed, determination etiology, typically defined by TOAST classification, paramount for prognostic...
The complexity of stroke sequelae, the heterogeneity outcome measures and rehabilitation pathways, lack extensively validated prediction models represent a challenge in predicting outcomes.
Introduction Previous studies showed that depression acts as an independent factor in functional recovery after stroke. In a prospective cohort of patients admitted to intensive inpatient rehabilitation stroke, we aimed test moderator the relationship between level at admission and effectiveness discharge. Methods All within 30 days from ischemic or hemorrhagic stroke 4 units were prospectively screened for eligibility multicenter observational study. Enrolled underwent evidence-based...
In 2008, a Working Group of the Italian Society Physical and Rehabilitation Medicine (SIMFER) published first minimum protocol for assessing stroke patients (PMIC) to define functional needs outcomes. The recent PMIC revision (PMIC2020) introduces document all rehabilitation settings, incorporating updated measurement tools.
Abstract Objectives This study aims to evaluate the diagnostic performance of NIHSS extinction and inattention item, compared results Oxford Cognitive Screen (OCS) heart subtest. Additionally, possible role visual field subtest on is explored discussed. Methods We analysed scores subtest, OCS a sample 118 post-stroke patients. Results Compared showed an accuracy 72.9% moderate agreement level (Cohen’s kappa = 0.404). Furthermore, decrease in detecting neglect (61.1%) was observed patients...
OBJECTIVE: To investigate cortical and subcortical gray matter (GM) white (WM) patterns of alterations characterizing Writer’s Cramp (WC) primary dystonia. BACKGROUND: Several recent neuroimaging studies showed thickening as well WM damage in sensorimotor extra-sensorimotor regions WC, suggesting a complex network dysfunction playing role the development dystonia. DESIGN/METHODS: T1-weighted diffusion tensor (DT) MRI scans were obtained from 19 WC patients 30 healthy controls (HC)....
OBJECTIVE: To assess the patterns of cortical and subcortical gray matter (GM) white (WM) damage in patients with Spasmodic Dysphonia (SD) primary focal dystonia compared healthy controls (HC). BACKGROUND: Recent advanced neuroimaging studies showed altered WM integrity internal capsule as well increased GM volume laryngeal sensorimotor cortex SD patients. Further are needed to confirm such structural changes associated disease. DESIGN/METHODS: T1-weighted diffusion tensor (DT) MRI scans...
Stroke survivors report physical, cognitive, and psychological impairments, with a consequent limitation of participation. Participation is the most context-related dimension functioning, but literature on participation in Italian stroke patients scant.This study aimed to describe recovery six months after validated version Frenchay Activity Index (FAI) investigate potential correlates higher scores.The prospective observational study.The cohort was enrolled four intensive inpatient...
Abstract Objectives This study aims to evaluate the diagnostic performance of NIHSS extinction and inattention item, compared results Oxford Cognitive Screen (OCS) heart subtest. Additionally, possible role visual field subtest on is explored discussed. Methods We analysed scores subtest, OCS a sample 118 post-stroke patients. Results Compared showed an accuracy 77.1% moderate agreement level (Cohen’s kappa = 0.455). Furthermore, decrease in detecting neglect (55.6%) was observed patients...