A5085247495- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Cardiac Imaging and Diagnostics
- Neurological and metabolic disorders
- Advanced MRI Techniques and Applications
- Mitochondrial Function and Pathology
- Blood Pressure and Hypertension Studies
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease and Spinal Disorders
- Restless Legs Syndrome Research
- Neurological diseases and metabolism
- Functional Brain Connectivity Studies
- Glycogen Storage Diseases and Myoclonus
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Autism Spectrum Disorder Research
- Psychosomatic Disorders and Their Treatments
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Health and Disease Prevention
- Neuroscience and Neuropharmacology Research
University of Pisa
2016-2025
Azienda Ospedaliera Universitaria Pisana
2012-2025
ASL Roma
2024
Ospedale San Filippo Neri
2024
Istituto Superiore di Sanità
2024
Azienda Ospedaliera San Giovanni Addolorata
2024
Servizio Sanitario Nazionale
2024
BioAge (Italy)
2024
Fondazione Poliambulanza Istituto Ospedaliero
2024
John Wiley & Sons (United States)
2023-2024
Abstract We performed a multicenter survey using semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association cognitive impairment, and impact on patients' quality life (QoL). found that 98.6% PD reported presence NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency nocturia (35%), drooling saliva...
Background — Forearm endothelial dysfunction, characterized by an impaired vasodilating response to acetylcholine (ACh), may be associated with several cardiovascular risk factors, including essential hypertension. Although the prognostic value of coronary dysfunction has been demonstrated, that forearm is still unknown. Methods and Results Endothelium-dependent -independent vasodilation was investigated in 225 never-treated hypertensive patients (age, 35 54 years) intra-arterial infusion...
Endothelial dysfunction has been reported in obese subjects, but its mechanism not elucidated. We have therefore investigated 1) the possible relationship among BMI, waist-to-hip ratio (WHR), and endothelium-dependent vasodilation 2) whether oxidative stress participates endothelial dysfunction. recruited 76 healthy subjects (50 men 26 women aged 21-45 years) measured their BMI (kg/m2), WHR, insulin resistance (IR) estimated by homeostasis model assessment (HOMA). Endothelium-dependent...
Despite the major finding of a genetic defect being responsible for Parkinson's disease (PD) phenotype in some kindreds with dominantly transmitted PD, role inheritance cause more widespread sporadic form is still unclear. Twin studies are classic tool assessing influence hereditary factors diseases; however, application this approach to late-onset illnesses, like poses problems because identification subclinical cases. In present longitudinal study we have used [18F]dopa and positron...
Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss nigrostriatal projections and consequent dysfunction striatocortical circuitries in Parkinson's disease (PD). Here, we have studied effects bilateral human embryonic grafts on movement-related activation frontal cortical areas 4 PD patients using H215O positron emission tomography a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by...
Behavioural disturbances are frequently observed in Parkinson's disease (PD), including mood and anxiety disorders. The existence of a comorbidity between such psychiatric disorders PD patients has been suggested only few studies. To assess the prevalence disturbances, rate PD. Secondary aim was to correlate with age, sex, laterality motor symptomatology, clinical features, severity disease, age onset duration, anti‐parkinsonian therapy. Ninety consecutive outpatients, 90 age‐ sex‐matched...
Abstract Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, social activities, correlate with reduced risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness action mechanisms elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We...
Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity compulsive symptoms never explored PD patients before initiation of DRT. We previously a 20% impulse control disorders (ICD) an Italian cohort.103 consecutive newly diagnosed drug-naïve (means: age = 60.5 ± 9.2 years; duration 15.4 15.3 months) were screened for sexual behavior,...
<h3>Background and aims</h3> (1) To establish the prevalence of mild cognitive impairment (MCI) in newly diagnosed drug-naive patients with Parkinson9s disease adopting recently proposed more conservative preliminary research criteria. (2) investigate relation between performances, MCI motor dysfunction. <h3>Methods</h3> 132 consecutive PD 100 healthy controls (HCs) underwent a neuropsychological evaluation covering different domains. Moreover, on basis Unified Disease Rating Scale II/III,...
ABSTRACT The objectives of this study were to evaluate the risk neuropathy in patients with Parkinson's disease (PD) and role levodopa exposure as a potential factor. A multicenter 330 PD 137 healthy controls comparable age distribution was performed. With respect exposure, 144 had long (≥3 years) (LELD), 103 short (<3 (SELD), 83 no (NOLD). Nerve function evaluated using reduced total score. Right sural sensory antidromic peroneal motor nerve conduction studies performed by...
To evaluate the anatomy of substantia nigra (SN) in healthy subjects by performing 7-T magnetic resonance (MR) imaging SN, and to prospectively define accuracy MR distinguishing Parkinson disease (PD) patients from on an individual basis.The protocol was approved Italian Ministry Health local competent ethics committee. SN described ex vivo a gross brain specimen using highly resolved proton-density (spin-echo proton density) gradient-recalled-echo (GRE) images, eight (mean age, 40.1 years)...
Rest tremor is one of the cardinal signs Parkinson's disease. Kinetic and postural tremors may also occur. The coexistence these three types at disease onset their subsequent progression could have important clinical therapeutic implications but remain to be fully elucidated. We aimed to: (i) evaluate prevalence in early stages disease; (ii) investigate longitudinally relationship between dopaminergic serotonergic terminal dysfunction, rest severity its response therapy. Progressive Markers...
<h3>Objective:</h3> To assess in a noninterventional setting the prevalence and severity of fatigue patients with Parkinson disease (PD). <h3>Methods:</h3> This was cross-sectional study conducted Italian PD. Objectives included evaluation current PD measured using 16-item Fatigue Scale (PFS-16), distressing (defined as PFS-16 mean score ≥3.3), assessment its clinical correlates. <h3>Results:</h3> A total 402 were enrolled 394 completed questionnaire (±SD) 2.87 ± 0.99. Of these, 136 (33.8%)...
Abstract Background The search for biomarkers in Parkinson’s disease (PD) is crucial to identify the early and monitor effectiveness of neuroprotective therapies. We aim assess whether a gene signature could be detected blood from early/mild PD patients that support diagnosis PD, focusing on genes found particularly altered substantia nigra sporadic PD. Results transcriptional expression seven selected was examined samples 62 stage 64 healthy age-matched controls. Stepwise multivariate...
Abstract Transportation of key proteins via extracellular vesicles has been recently implicated in various neurodegenerative disorders, including Parkinson’s disease, as a new mechanism disease spreading and source biomarkers. Extracellular likely to be derived from the brain can isolated peripheral blood have reported contain higher levels α-synuclein (α-syn) patients. However, very little is known about multiple system atrophy, that, like involves pathological α-syn aggregation, though...
Abstract Cerebello-thalamo-cortical network is suggested to be involved in the pathophysiology of Essential Tremor (ET). 23 patients with ET and matched HC underwent a 3T-MRI acquisition resting state sequence. Connectivity was investigated using seed-based regression analyses approach. In were observed: Reduced connectivity between left primary motor cortex (M1) seed right premotor cerebellum bilateral premotor, parietal areas, supplementary area (SMA); I ncreased somatosensory (S1) M1,...