A5064076619- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Solid-state spectroscopy and crystallography
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Fetal and Pediatric Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Molecular Spectroscopy and Structure
- Spinal Fractures and Fixation Techniques
- MRI in cancer diagnosis
- Biosensors and Analytical Detection
- Ultrasound and Hyperthermia Applications
- Vascular Malformations Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Spinal Dysraphism and Malformations
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neonatal and fetal brain pathology
- Electron Spin Resonance Studies
Azienda Ospedaliera Universitaria Pisana
2014-2024
University of Pisa
2011-2024
Ospedale di Bolzano
2007-2017
Ospedale Santa Chiara
2013-2016
Western Regional Hospital
2011
University of Florence
2007-2010
Ospedale Bellaria
1999
Policlinico San Matteo Fondazione
1997
University of Pavia
1988
Istituto di Chimica Biomolecolare
1974
Abstract Cerebello-thalamo-cortical network is suggested to be involved in the pathophysiology of Essential Tremor (ET). 23 patients with ET and matched HC underwent a 3T-MRI acquisition resting state sequence. Connectivity was investigated using seed-based regression analyses approach. In were observed: Reduced connectivity between left primary motor cortex (M1) seed right premotor cerebellum bilateral premotor, parietal areas, supplementary area (SMA); I ncreased somatosensory (S1) M1,...
Standard neuroimaging fails in defining the anatomy of substantia nigra and has a marginal role diagnosis Parkinson disease. Recently 7T MR target imaging been useful diagnosing We performed comparative study to evaluate whether susceptibility-weighted angiography can diagnose disease with 3T scanner.Fourteen patients 13 healthy subjects underwent examination at by using angiography. Two expert blinded observers 1 neuroradiology fellow evaluated images sample identify abnormalities...
Differential diagnosis between Parkinson's disease (PD) and Atypical Parkinsonisms, mainly Progressive Supranuclear Palsy (PSP) Multiple System Atrophy (MSA), remains challenging. The low sensitivity of macroscopic findings at imaging might limit early diagnosis. availability iron-sensitive MR techniques high magnetic field scanners provides new insights in evaluating brain structures degenerative parkinsonisms. Quantitative Susceptibility Mapping (QSM) allows quantifying tissue iron content...
Summary Objective Juvenile myoclonic epilepsy ( JME ) is a young‐onset electroclinical syndrome, characterized by myoclonic, generalized tonic–clonic, and possibly typical absence seizures. Interictal electroencephalography EEG) displays 3–6 Hz spike/polyspike wave pattern. Photosensitivity common. Our aim was to explore the blood oxygen level–dependent BOLD) response evoked highly provocative photic stimulus in cohort of people with compared group nonphotosensitive healthy controls,...
Objectives To explore the role of available midbrain-based MRI morphometric assessments in (1) differentiating among progressive supranuclear palsy (PSP) subtypes (PSP Richardson’s syndrome (PSP-RS), PSP with predominant parkinsonism (PSP-P) and other variant syndromes (vPSP)), (2) supporting diagnosis compared Parkinson’s disease (PD) healthy controls (HC). Methods Seventy-eight patients (38 PSP-RS, 21 PSP-P 19 vPSP), 35 PD 38 HC were included present analysis. Available calculated for all...
Myotonic dystrophy type 1 (DM1) has a wide phenotypic spectrum and potentially may affect central nervous system with mild to severe involvement. Our aim was investigate grey matter (GM) white (WM) structural alterations in sample of adult-onset DM1 patients evaluate relationship clinical cognitive variables. Thirty underwent neuropsychological investigation 3T-MRI protocol. GM WM changes were evaluated calculating brain parenchymal fraction (BPF), voxel-based morphometry (VBM), lesion load...
The term leuko‐araiosis (LA) describes a common chronic affection of the cerebral white matter (WM) in elderly due to small vessel disease with variable clinical correlates. To explore whether severity LA entails some adaptive reorganization cortex we evaluated functional MRI (fMRI) cortical activation pattern during simple motor task 60 subjects mild cognitive impairment and moderate or severe (moderate‐to‐severe group, n = 46) (mild 14) extension on visual rating. microstructural damage...
The ventriculus terminalis, an embryological remnant consisting of the ependymal-lined space conus medullaris, can occasionally become symptomatic after cystic dilation. In existing literature, 32 cases, preferred type management (conservative vs surgical) is still debated. object this study was to report surgical results in a consecutive series 10 adult patients with dilation terminalis (CDVT), match them data retrieved from relevant and specifically validate new recent clinical...
To obtain three-dimensional (3D), quantitative and motion-robust imaging with magnetic resonance fingerprinting (MRF).Our acquisition is based on a 3D spiral projection k-space scheme. We compared different orderings of trajectory interleaves in terms rigid motion-correction robustness. In all tested orderings, we considered the whole dataset as sum 56 segments 7-s duration, acquired sequentially same flip angle schedule. performed separate image reconstruction for each segment, producing...
Pleomorphic Xanthoastrocytoma (PXA) is a rare brain tumour, most commonly affecting children and young adults. To date, only few data regarding the long-term follow-up of these patients after surgery are available. The aim this study to describe our single-institution experience in surgical management particular glioma over period 18 years.We performed retrospective review all cases PXA (40 patients) operated upon at Department Neurosurgery Verona, Italy, between 1990 2008. impact clinical,...
Magnetic resonance fingerprinting (MRF) is highly promising as a quantitative MRI technique due to its accuracy, robustness, and efficiency. Previous studies have found high repeatability reproducibility of 2D MRF acquisitions in the brain. Here, we extended our investigations 3D covering whole brain using spiral projection k-space trajectories. Our travelling head study acquired test/retest data from brains 12 healthy volunteers 8 systems (3 at 3 T 5 1.5 T, all single vendor), design not...
Abstract Background and purpose In the quest for in vivo diagnostic biomarkers to discriminate Parkinson's disease (PD) from progressive supranuclear palsy (PSP) multiple system atrophy (MSA, mainly p phenotype), many advanced magnetic resonance imaging (MRI) techniques have been studied. Morphometric indices, such as Magnetic Resonance Parkinsonism Index (MRPI), demonstrated high value comparison between PD PSP. The potential of quantitative susceptibility mapping (QSM) was hypothesized,...
Abstract Friedreich's ataxia (FRDA) is associated with a distributed pattern of neurodegeneration in the spinal cord and brain secondary to selective neuronal loss. We used functional MR Imaging (fMRI) explore activation FRDA patients during two motor‐sensory tasks different complexity, i.e. continuous hand tapping writing “8” figure, right dominant without visual feedback. Seventeen groups age‐matched healthy controls were recruited. Task execution was monitored recorded using MR‐compatible...
The decline of voluntary bulbar functions such as speech and swallowing are among the clinical manifestations amyotrophic lateral sclerosis (ALS) influencing a worst prognosis. Differential diagnosis between contribution upper motor neuron (UMN) lower degeneration to impairment is often hard. Thinning T2* hypointensity primary cortex have been recently suggested possible MRI markers UMN in ALS patients, but little research has purposely targeted orofacial region (fM1). With aim finding an...
Pathological and imaging data indicate that amyotrophic lateral sclerosis (ALS) is a multisystem disease involving several cerebral cortical areas. Advanced quantitative magnetic resonance (MRI) techniques enable to explore in vivo the volume microstructure of cortex ALS. We studied with combined voxel-based morphometry (VBM) magnetization transfer (MT) approach capability MRI identify areas affected by neurodegeneration ALS patients. Eighteen patients 18 age-matched healthy controls were...